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Molecular discovery has brought great benefits to the chemical industry. Various molecule design techniques are developed to identify molecules with desirable properties. Traditional optimization methods, such as genetic algorithms,…

Biomolecules · Quantitative Biology 2025-11-05 Chris Zhuang , Debadyuti Mukherjee , Yingzhou Lu , Tianfan Fu , Ruqi Zhang

Crystal structure prediction (CSP) has emerged as one of the most important approaches for discovering new materials. CSP algorithms based on evolutionary algorithms and particle swarm optimization have discovered a great number of new…

Materials Science · Physics 2022-04-06 Wenhui Yang , Edirisuriya M. Dilanga Siriwardane , Jianjun Hu

As in many other fields, the rapid rise of generative artificial intelligence is reshaping materials discovery by offering new ways to propose crystal structures and, in some cases, even predict desired properties. This review provides a…

Challenges in natural sciences can often be phrased as optimization problems. Machine learning techniques have recently been applied to solve such problems. One example in chemistry is the design of tailor-made organic materials and…

Neural and Evolutionary Computing · Computer Science 2020-01-17 AkshatKumar Nigam , Pascal Friederich , Mario Krenn , Alán Aspuru-Guzik

A novel Genetic Algorithm is described that is suitable for determining the global minimum energy configurations of crystal structures and which can also be used as a polymorph search technique. This algorithm requires no prior assumptions…

Other Condensed Matter · Physics 2007-05-23 N. L. Abraham , M. I. J. Probert

A genetic algorithm (GA) is a search method that optimises a population of solutions by simulating natural evolution. Good solutions reproduce together to create better candidates. The standard GA assumes that any two solutions can mate.…

Neural and Evolutionary Computing · Computer Science 2021-04-12 Aymeric Vie

Crystal structure prediction is one of the major unsolved problems in materials science. Traditionally, this problem is formulated as a global optimization problem for which global search algorithms are combined with first principle free…

Materials Science · Physics 2023-06-13 Jianjun Hu , Yong Zhao , Qin Li , Yuqi Song , Rongzhi Dong , Wenhui Yang , Edirisuriya MD Siriwardane

The implementation of adaptive genetic algorithms (AGA) for optimization problems has proven to be superior than many other methods due to its nature of producing more robust and high quality solutions. Considering the complexity involved…

Computational Physics · Physics 2024-11-28 Brandon Willnecker , Mervlyn Moodley

Generative design marks a significant data-driven advancement in the exploration of novel inorganic materials, which entails learning the symmetry equivalent to the crystal structure prediction (CSP) task and subsequent learning of their…

Materials Science · Physics 2024-03-22 Ruiming Zhu , Wei Nong , Shuya Yamazaki , Kedar Hippalgaonkar

The discovery of inorganic crystal structures with targeted properties is a significant challenge in materials science. Generative models, especially state-of-the-art diffusion models, offer the promise of modeling complex data…

Crystal structure prediction algorithms have become powerful tools for materials discovery in recent years, however, they are usually limited to relatively small systems. The main challenge is that the number of local minima grows…

Materials Science · Physics 2022-02-09 Hao Gao , Junjie Wang , Yu Han , Jian Sun

We present Genarris, a Python package that performs configuration space screening for molecular crystals of rigid molecules by random sampling with physical constraints. For fast energy evaluations Genarris employs a Harris approximation,…

The genetic algorithm (GA) is an optimization and search technique based on the principles of genetics and natural selection. A GA allows a population composed of many individuals to evolve under specified selection rules to a state that…

Neural and Evolutionary Computing · Computer Science 2016-08-14 Yılmaz Kaya , Murat Uyar , Ramazan Tek\D{j}n

We have developed an efficient and reliable methodology for crystal structure prediction, merging ab initio total-energy calculations and a specifically devised evolutionary algorithm. This method allows one to predict the most stable…

Materials Science · Physics 2009-11-18 A. R. Oganov , C. W. Glass

In this research, we investigate the possibility of applying a search strategy to genetic algorithms to explore the entire genetic tree structure. Several methods aid in performing tree searches; however, simpler algorithms such as…

Neural and Evolutionary Computing · Computer Science 2023-08-10 Akshay Hebbar

Protein structure prediction is considered as one of the most challenging and computationally intractable combinatorial problem. Thus, the efficient modeling of convoluted search space, the clever use of energy functions, and more…

Neural and Evolutionary Computing · Computer Science 2016-07-22 Mahmood A. Rashid , Sumaiya Iqbal , Firas Khatib , Md Tamjidul Hoque , Abdul Sattar

Genetic algorithms are a class of heuristic search techniques that apply basic evolutionary operators in a computational setting. We have designed a fully parallel and distributed hardware/software implementation of the generalized…

Astrophysics · Physics 2009-11-07 T. S. Metcalfe , P. Charbonneau

In recent years, machine learning has seen an increasing presencein a large variety of fields, especially in health care and bioinformatics.More specifically, the field where machine learning algorithms have found most applications is…

Neural and Evolutionary Computing · Computer Science 2020-08-21 Mekaal Swerhun , Jasmine Foley , Brandon Massop , Vijay Mago

Crystalline materials are widely used in technological applications, yet their discovery remains a significant challenge. As their properties are driven by structure, crystal structure prediction (CSP) methods play a central role in…

Machine Learning · Computer Science 2026-04-28 Stavros Gerolymatos , J. Kyle Brubaker , Martin J. A. Schuetz , Vladimir V. Gusev

While crystal structure prediction (CSP) remains a longstanding challenge, we introduce ParetoCSP, a novel algorithm for CSP, which combines a multi-objective genetic algorithm (MOGA) with a neural network inter-atomic potential (IAP) model…

Materials Science · Physics 2023-09-14 Sadman Sadeed Omee , Lai Wei , Jianjun Hu