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Health policy decisions are often informed by estimates of long-term survival based primarily on short-term data. A range of methods are available to include longer-term information, but there has previously been no comprehensive and…

Methodology · Statistics 2025-05-05 Christopher Jackson

More than 20 years after the end of NASA's Compton Gamma-Ray Observatory mission, the data collected by its Imaging Compton Telescope (COMPTEL) still provide the most comprehensive and deepest view of our Universe in MeV gamma rays. While…

Instrumentation and Methods for Astrophysics · Physics 2022-09-21 Jürgen Knödlseder , Werner Collmar , Manon Jarry , Mark McConnell

MatNexus is a specialized software for the automated collection, processing, and analysis of text from scientific articles. Through an integrated suite of modules, the MatNexus facilitates the retrieval of scientific articles, processes…

Materials Science · Physics 2024-03-21 Lei Zhang , Markus Stricker

Metagenomics has led to significant advancements in many fields. Metagenomic analysis commonly involves the key tasks of determining the species present in a sample and their relative abundances. These tasks require searching large…

Graph neural networks (GNNs) have emerged as one of the most effective ML techniques for drug effect prediction from drug molecular graphs. Despite having immense potential, GNN models lack performance when using datasets that contain…

Machine Learning · Computer Science 2024-10-15 Avishek Bose , Guojing Cong

Synthetic data generation, a cornerstone of Generative Artificial Intelligence, promotes a paradigm shift in data science by addressing data scarcity and privacy while enabling unprecedented performance. As synthetic data becomes more…

Machine Learning · Statistics 2024-03-12 Xiaotong Shen , Yifei Liu , Rex Shen

The accurate quantification of gene expression levels is crucial for transcriptome study. Microarray platforms are commonly used for simultaneously interrogating thousands of genes in the past decade, and recently RNA-Seq has emerged as a…

Applications · Statistics 2014-08-01 Zhaonan Sun , Thomas Kuczek , Yu Zhu

We explore connections between metagenomic read assignment and the quantification of transcripts from RNA-Seq data. In particular, we show that the recent idea of pseudoalignment introduced in the RNA-Seq context is suitable in the…

Quantitative Methods · Quantitative Biology 2015-12-02 Lorian Schaeffer , Harold Pimentel , Nicolas Bray , Páll Melsted , Lior Pachter

Galaxy groups are essential for studying the distribution of matter on a large scale in redshift surveys and for deciphering the link between galaxy traits and their associated halos. In this work, we propose a widely applicable method for…

Cosmology and Nongalactic Astrophysics · Physics 2025-04-03 Juntao Ma , Jie Wang , Tianxiang Mao , Hongxiang Chen , Yuxi Meng , Xiaohu Yang , Qingyang Li

For many conditions, it is of clinical importance to know not just the ability of a test to distinguish between those with and without the disease, but also the sensitivity to detect disease at different stages: in particular, the test's…

Methodology · Statistics 2026-02-10 Efthymia Derezea , Nicky J Welton , Gabriel Rogers , Hayley E Jones

In the era of exploding survey volumes, traditional methods of spectroscopic analysis are being pushed to their limits. In response, we develop deep-REMAP, a novel deep learning framework that utilizes a regularized, multi-task approach to…

Instrumentation and Methods for Astrophysics · Physics 2025-10-13 Sankalp Gilda

While multi-modal models have successfully integrated information from image, video, and audio modalities, integrating graph modality into large language models (LLMs) remains unexplored. This discrepancy largely stems from the inherent…

Computation and Language · Computer Science 2023-10-13 Yuanchun Shen , Ruotong Liao , Zhen Han , Yunpu Ma , Volker Tresp

Scientific computing libraries, either being in-house or open-source, have experienced enormous progress in both engineering and scientific research. It is therefore essential to ensure that the modifications in the source code aroused by…

Computational Physics · Physics 2023-05-12 Bo Zhang , Chi Zhang , Xiangyu Hu

Metagenome assembly is the process of transforming a set of short, overlapping, and potentially erroneous DNA segments from environmental samples into the accurate representation of the underlying microbiomes's genomes. State-of-the-art…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-09-20 Evangelos Georganas , Rob Egan , Steven Hofmeyr , Eugene Goltsman , Bill Arndt , Andrew Tritt , Aydin Buluc , Leonid Oliker , Katherine Yelick

Highly accurate models of the galaxy population over cosmological volumes are necessary in order to predict the performance of upcoming cosmological missions. We present a data-driven model of the galaxy population constrained by deep 0.1-8…

Instrumentation and Methods for Astrophysics · Physics 2016-06-22 Nathaniel R. Stickley , Peter Capak , Daniel Masters , Roland de Putter , Olivier Doré , Jamie Bock

The R package trajmsm provides functions designed to simplify the estimation of the parameters of a model combining latent class growth analysis (LCGA), a trajectory analysis technique, and marginal structural models (MSMs) called LCGA-MSM.…

We present the GEOMAX algorithm and its Python implementation for a two-step compression of bispectrum measurements. The first step groups bispectra by the geometric properties of their arguments; the second step then maximises the Fisher…

Cosmology and Nongalactic Astrophysics · Physics 2020-07-06 Davide Gualdi , Héctor Gil-Marín , Marc Manera , Benjamin Joachimi , Ofer Lahav

Phylogenetic placement refers to a family of tools and methods to analyze, visualize, and interpret the tsunami of metagenomic sequencing data generated by high-throughput sequencing. Compared to alternative (e. g., similarity-based)…

Populations and Evolution · Quantitative Biology 2025-01-09 Lucas Czech , Alexandros Stamatakis , Micah Dunthorn , Pierre Barbera

Stellar physics and evolution calculations enable a broad range of research in astrophysics. Modules for Experiments in Stellar Astrophysics (MESA) is a suite of open source libraries for a wide range of applications in computational…

Solar and Stellar Astrophysics · Physics 2010-12-17 Bill Paxton , Lars Bildsten , Aaron Dotter , Falk Herwig , Pierre Lesaffre , Frank Timmes

We propose a Web-Mashup Application Service Framework for Multivariate Time Series Analytics (MTSA) that supports the services of model definitions, querying, parameter learning, model evaluations, data monitoring, decision recommendations,…

Artificial Intelligence · Computer Science 2022-10-19 Chun-Kit Ngan , Alexander Brodsky
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