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Large language model (LLM) agents are constrained by limited context windows, necessitating external memory systems for long-term information understanding. Current memory-augmented agents typically depend on pre-defined instructions and…

Computation and Language · Computer Science 2025-10-01 Yu Wang , Ryuichi Takanobu , Zhiqi Liang , Yuzhen Mao , Yuanzhe Hu , Julian McAuley , Xiaojian Wu

Maintaining a consistent persona is a key quality for any open domain dialogue system. Current state-of-the-art systems do this by training agents with supervised learning or online reinforcement learning (RL). However, systems trained with…

Computation and Language · Computer Science 2023-10-18 Ryan Shea , Zhou Yu

The prediction of mild cognitive impairment (MCI) conversion to Alzheimer's disease (AD) is important for early treatment to prevent or slow the progression of AD. To accurately predict the MCI conversion to stable MCI or progressive MCI,…

Computer Vision and Pattern Recognition · Computer Science 2023-07-17 Linfeng Liu , Junyan Lyu , Siyu Liu , Xiaoying Tang , Shekhar S. Chandra , Fatima A. Nasrallah

Mild cognitive impairment(MCI) is a precursor of Alzheimer's disease(AD), and the detection of MCI is of great clinical significance. Analyzing the structural brain networks of patients is vital for the recognition of MCI. However, the…

Neurons and Cognition · Quantitative Biology 2022-08-19 Heng Kong , Shuqiang Wang

Alzheimer's disease (AD) and mild cognitive impairment (MCI), continue to be widely studied. While there is no consensus on whether MCIs actually "convert" to AD, the more important question is not whether MCIs convert, but what is the best…

Neurons and Cognition · Quantitative Biology 2015-05-28 Yaman Aksu , David J. Miller , George Kesidis , Don C. Bigler , Qing X. Yang

Reinforcement learning (RL) has shown great promise for developing dialogue management (DM) agents that are non-myopic, conduct rich conversations, and maximize overall user satisfaction. Despite recent developments in RL and language…

Machine Learning · Computer Science 2023-10-31 Dhawal Gupta , Yinlam Chow , Aza Tulepbergenov , Mohammad Ghavamzadeh , Craig Boutilier

Dementia is a progressive cognitive syndrome with Alzheimer's disease (AD) as the leading cause. Conversation-based AD detection offers a cost-effective alternative to clinical methods, as language dysfunction is an early biomarker of AD.…

Computation and Language · Computer Science 2025-02-27 Arezo Shakeri , Mina Farmanbar , Krisztian Balog

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders worldwide. As it progresses, it leads to the deterioration of cognitive functions. Since AD is irreversible, early diagnosis is crucial for managing its…

Computer Vision and Pattern Recognition · Computer Science 2025-08-28 Mahdieh Behjat Khatooni , Mohsen Soryani

This study explores a multi-lingual audio self-supervised learning model for detecting mild cognitive impairment (MCI) using the TAUKADIAL cross-lingual dataset. While speech transcription-based detection with BERT models is effective,…

Audio and Speech Processing · Electrical Eng. & Systems 2025-01-28 Yueguan Wang , Tatsunari Matsushima , Soichiro Matsushima , Toshimitsu Sakai

Alzheimer's disease and related dementias(ADRD) affect nearly five million older adults in the United States, yet more than half remain undiagnosed. Speech-based natural language processing(NLP) offers a scalable approach for detecting…

Mild cognitive impairment (MCI) is a major public health concern due to its high risk of progressing to dementia. This study investigates the potential of detecting MCI with spontaneous voice assistant (VA) commands from 35 older adults in…

Audio and Speech Processing · Electrical Eng. & Systems 2024-11-08 Nana Lin , Youxiang Zhu , Xiaohui Liang , John A. Batsis , Caroline Summerour

The global prevalence of dementia is projected to double by 2050, highlighting the urgent need for scalable diagnostic tools. This study utilizes digital cognitive tasks with eye-tracking data correlated with memory processes to distinguish…

Human-Computer Interaction · Computer Science 2025-08-28 Tomás Silva Santos Rocha , Anastasiia Mikhailova , Moreno I. Coco , José Santos-Victor

Reinforcement Learning (RL) faces significant challenges in adaptive healthcare interventions, such as dementia care, where data is scarce, decisions require interpretability, and underlying patient-state dynamic are complex and causal in…

Robotics · Computer Science 2025-12-02 Wenzheng Zhao , Ran Zhang , Ruth Palan Lopez , Shu-Fen Wung , Fengpei Yuan

Class-Incremental Learning (CIL) [40] trains classifiers under a strict memory budget: in each incremental phase, learning is done for new data, most of which is abandoned to free space for the next phase. The preserved data are exemplars…

Computer Vision and Pattern Recognition · Computer Science 2023-01-18 Yaoyao Liu , Bernt Schiele , Qianru Sun

Detecting Mild Cognitive Impairment from picture descriptions is critical yet challenging, especially in multilingual and multiple picture settings. Prior work has primarily focused on English speakers describing a single picture (e.g., the…

Computation and Language · Computer Science 2025-09-04 Kristin Qi , Jiali Cheng , Youxiang Zhu , Hadi Amiri , Xiaohui Liang

People with type 1 diabetes (T1D) struggle to calculate the optimal insulin dose at mealtime, especially when under multiple daily injections (MDI) therapy. Effectively, they will not always perform rigorous and precise calculations, but…

Artificial Intelligence · Computer Science 2023-09-19 Anas El Fathi , Marc D. Breton

A key issue to Alzheimer's disease clinical trial failures is poor participant selection. Participants have heterogeneous cognitive trajectories and many do not decline during trials, which reduces a study's power to detect treatment…

Quantitative Methods · Quantitative Biology 2022-05-05 Angela Tam , César Laurent , Serge Gauthier , Christian Dansereau

Reinforcement learning (RL) agents often suffer from high sample complexity in sparse or delayed reward settings due to limited prior structure. Large language models (LLMs) can provide subgoal decompositions, plausible trajectories, and…

Machine Learning · Computer Science 2026-02-23 Narjes Nourzad , Carlee Joe-Wong

Early detection of cognitive decline is crucial for enabling interventions that can slow neurodegenerative disease progression. Traditional diagnostic approaches rely on labor-intensive clinical assessments, which are impractical for…

Computation and Language · Computer Science 2025-09-04 Kristin Qi , Youxiang Zhu , Caroline Summerour , John A. Batsis , Xiaohui Liang

Early diagnosis of dementia, particularly in the prodromal stage (i.e., mild cognitive impairment, or MCI), has become a research and clinical priority but remains challenging. Automated analysis of the drawing process has been studied as a…

Signal Processing · Electrical Eng. & Systems 2022-11-17 Yasunori Yamada , Masatomo Kobayashi , Kaoru Shinkawa , Miyuki Nemoto , Miho Ota , Kiyotaka Nemoto , Tetsuaki Arai