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We have developed a system for tapered fiber measurements of optomechanical resonators inside a dilution refrigerator, which is compatible with both on- and off-chip devices. Our apparatus features full three-dimensional control of the…

Mesoscale and Nanoscale Physics · Physics 2015-01-19 A. J. R. MacDonald , G. G. Popowich , B. D. Hauer , P. H. Kim , A. Fredrick , X. Rojas , P. Doolin , J. P. Davis

Fluorescence imaging allows for non-invasively visualizing and measuring key physiological parameters like pH and dissolved oxygen. In our work, we created two ratiometric fluorescent microsensors designed for accurately tracking dissolved…

Due to high dynamic range and ease of use, continuous wave terahertz spectroscopy is an increasingly popular method for optical characterization of components used in cosmic microwave background (CMB) experiments. In this work, we describe…

Instrumentation and Methods for Astrophysics · Physics 2024-07-09 Gaganpreet Singh , Rustam Balafendiev , Zeshen Bao , Thomas J. L. J. Gascard , Jon E. Gudmundsson , Gagandeep Kaur , Vid Primožič

The dynamic architecture of the microtubule cytoskeleton is crucial for cell division, motility and morphogenesis. The dynamic properties of microtubules - growth, shrinkage, nucleation and severing - are regulated by an arsenal of…

Quantitative Methods · Quantitative Biology 2021-07-06 Yin-wei Kuo , Jonathon Howard

Thermo-elastic conversion of electromagnetic wave into ultrasound wave has enabled diverse biomedical applications such as photoacoustic imaging. Microwave, which has ~10 cm long wavelength, can penetrate deeper into tissue than photons,…

Applied Physics · Physics 2019-11-20 Lu Lan , Yueming Li , Tiffany Yang-Tran , Yingchun Cao , Ji-Xin Cheng

All quantum optomechanics experiments to date operate at cryogenic temperatures, imposing severe technical challenges and fundamental constraints. Here we present a novel design of on-chip mechanical resonators which exhibit fundamental…

Mesoscale and Nanoscale Physics · Physics 2016-04-07 Richard A. Norte , Joao P. Moura , Simon Gröblacher

We experimentally observe the shear and secondary compression wave inside soft porous water-saturated melamine foams by high frame rate ultrasound imaging. Both wave speeds are supported by the weak frame of the foam. The first and second…

Scanning helium microscopy (SHeM) is an emerging technique that uses a beam of neutral atoms to image and analyse surfaces. The low energies ($\sim$64 meV) and completely non-destructive nature of the probe particles provide exceptional…

Contemporary cosmic microwave background (CMB) experiments typically have observing bands covering the range 20 - 800 GHz. Certain science goals, including the detection of $\mu$-type distortions to the CMB spectrum and the characterization…

Cosmology and Nongalactic Astrophysics · Physics 2024-06-07 David Zegeye , Thomas Crawford , Jens Chluba , Mathieu Remazeilles , Keith Grainge

We develop a compact whispering-gallery-mode (WGM) sensing system by integrating multiple components, including a tunable laser, a temperature controller, a function generator, an oscilloscope, a photodiode detector, and a testing computer,…

Optics · Physics 2016-11-23 Xiangyi Xu , Xuefeng Jiang , Guangming Zhao , Lan Yang

Context. Millimetre-wave astronomy is an important tool for both general astrophysics studies and cosmology. A large number of unidentified sources are being detected by the large field-of-view continuum instruments operating on large…

Instrumentation and Methods for Astrophysics · Physics 2023-03-29 Usasi Chowdhury , Florence Levy-Bertrand , Martino Calvo , Johannes Goupy , Alessandro Monfardini

In many real-world scientific problems, generating ground truth (GT) for supervised learning is almost impossible. The causes include limitations imposed by scientific instrument, physical phenomenon itself, or the complexity of modeling.…

Image and Video Processing · Electrical Eng. & Systems 2020-08-31 Arif Ahmed Sekh , Ida S. Opstad , Rohit Agarwal , Asa Birna Birgisdottir , Truls Myrmel , Balpreet Singh Ahluwalia , Krishna Agarwal , Dilip K. Prasad

The whispering gallery modes (WGMs) of optical resonators have prompted intensive research efforts due to their usefulness in the field of biological sensing, and their employment in nonlinear optics. While much information is available in…

The tumour microenvironment (TME) strongly influences tumorigenesis and metastasis. Two of the most characterized properties of the TME are acidosis and hypoxia, both of which are considered hallmarks of tumours as well as critical factors…

We theoretically demonstrate an efficient scheme to build a microwave (MW) assisted optical waveguide in an inhomogeneously broadened vapor medium that is made of active 87 Rb atoms and inactive buffer gas atoms. We exploit the sensitive…

Optics · Physics 2020-10-09 Nawaz Sarif Mallick , Tarak Nath Dey

Fluorescence lifetime imaging microscopy (FLIM) is an important technique to understand the chemical micro-environment in cells and tissues since it provides additional contrast compared to conventional fluorescence imaging. When two…

Image and Video Processing · Electrical Eng. & Systems 2022-01-19 Varun Mannam , Xiaotong Yuan , Scott Howard

Fibered confocal fluorescence microscopy (FCFM) is a new technique that can be used during a bronchoscopy to analyze the nature of the human bronchial and alveolar mucosa fluorescence microstructure. An endoscopic fibered confocal…

Medical Physics · Physics 2008-02-27 G. Bourg-Heckly , L. Thiberville , C. Vever-Bizet , B. Viellerobe

Nuclear magnetic resonance (NMR) experiments on subnanoliter (sub-nL) volumes are hindered by the limited sensitivity of the detector and the difficulties in positioning and holding such small samples in proximity of the detector. Here, we…

Biological Physics · Physics 2018-07-04 E. Montinaro , M. Grisi , M. C. Letizia , L. Pethö , M. A. M. Gijs , R. Guidetti , J. Michler , J. Brugger , G. Boero

Accurate MR signal simulation, including microvascular structures and water diffusion, is crucial for MRI techniques like fMRI BOLD modeling and MR vascular Fingerprinting (MRF), which use susceptibility effects on MR signals for tissue…

The metabolism of an organism is regulated at the cellular level, yet is strongly influenced by its environment. The precise metabolomic study of living organisms is currently hampered by measurement sensitivity: most metabolomic…

Quantitative Methods · Quantitative Biology 2017-07-28 Jan G. Korvink , Vlad Badilita , Lorenzo Bordonali , Mazin Jouda , Dario Mager , Neil MacKinnon