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The like regular expression predicate has been part of the SQL standard since at least 1989. However, despite its popularity and wide usage, database vendors provide only limited indexing support for regular expression queries which almost…

Databases · Computer Science 2011-08-16 Dominic Tsang , Sanjay Chawla

Index plays an essential role in modern database engines to accelerate the query processing. The new paradigm of "learned index" has significantly changed the way of designing index structures in DBMS. The key insight is that indexes could…

Databases · Computer Science 2021-04-14 Jiacheng Wu , Yong Zhang , Shimin Chen , Jin Wang , Yu Chen , Chunxiao Xing

High-throughput sequencing technologies have led to explosive growth of genomic databases; one of which will soon reach hundreds of terabytes. For many applications we want to build and store indexes of these databases but constructing such…

Data Structures and Algorithms · Computer Science 2018-11-19 Christina Boucher , Travis Gagie , Alan Kuhnle , Ben Langmead , Giovanni Manzini , Taher Mun

There now exist compact indexes that can efficiently list all the occurrences of a pattern in a dataset consisting of thousands of genomes, or even all the occurrences of all the pattern's maximal exact matches (MEMs) with respect to the…

Data Structures and Algorithms · Computer Science 2022-09-20 Adrián Goga , Andrej Baláž , Alessia Petescia , Travis Gagie

Generative probabilistic models have shown promise in designing artificial RNA and protein sequences but often suffer from high rates of false positives, where sequences predicted as functional fail experimental validation. To address this…

Biomolecules · Quantitative Biology 2025-04-03 Francesco Calvanese , Giovanni Peinetti , Polina Pavlinova , Philippe Nghe , Martin Weigt

Data compression is a powerful tool for managing massive but repetitive datasets, especially schemes such as grammar-based compression that support computation over the data without decompressing it. In the best case such a scheme takes a…

Data Structures and Algorithms · Computer Science 2019-06-04 Travis Gagie , Tomohiro I , Giovanni Manzini , Gonzalo Navarro , Hiroshi Sakamoto , Yoshimasa Takabatake

Large language models (LLMs) are revolutionizing conversational recommender systems by adeptly indexing item content, understanding complex conversational contexts, and generating relevant item titles. However, controlling the distribution…

Information Retrieval · Computer Science 2024-05-21 Zhankui He , Zhouhang Xie , Harald Steck , Dawen Liang , Rahul Jha , Nathan Kallus , Julian McAuley

We first review how we can store a run-length compressed suffix array (RLCSA) for a text $T$ of length $n$ over an alphabet of size $\sigma$ whose Burrows-Wheeler Transform (BWT) consists of $r$ runs in $O \left( \rule{0ex}{2ex} r \log (n /…

Data Structures and Algorithms · Computer Science 2025-04-22 Nathaniel K. Brown , Travis Gagie , Giovanni Manzini , Gonzalo Navarro , Marinella Sciortino

Text indexing is a fundamental and well-studied problem. Classic solutions either replace the original text with a compressed representation, e.g., the FM-index and its variants, or keep it uncompressed but attach some redundancy - an index…

Data Structures and Algorithms · Computer Science 2026-02-05 Lorraine A. K. Ayad , Gabriele Fici , Ragnar Groot Koerkamp , Grigorios Loukides , Rob Patro , Giulio Ermanno Pibiri , Solon P. Pissis

We present a new approach for the analysis of genome-wide expression data. Our method is designed to overcome the limitations of traditional techniques, when applied to large-scale data. Rather than alloting each gene to a single cluster,…

Biological Physics · Physics 2009-11-07 Sven Bergmann , Jan Ihmels , Naama Barkai

Low-Rank Adaptation (LoRA) emerges as a popular parameter-efficient fine-tuning (PEFT) method, which proposes to freeze pretrained model weights and update an additive low-rank trainable matrix. In this work, we study the enhancement of…

Machine Learning · Computer Science 2024-06-06 Fangzhao Zhang , Mert Pilanci

Realignment becomes necessary when a language model (LM) fails to meet expected performance. We propose a flexible realignment framework that supports quantitative control of alignment degree during training and inference. This framework…

Computation and Language · Computer Science 2026-01-13 Wenhong Zhu , Ruobing Xie , Weinan Zhang , Rui Wang

This article introduces a new DNA sequence compression algorithm which is based on LUT and LZ77 algorithm. Combined a LUT-based pre-coding routine and LZ77 compression routine,this algorithm can approach a compression ratio of 1.9bits…

Information Theory · Computer Science 2007-07-16 Sheng Bao , Shi Chen , Zhiqiang Jing , Ran Ren

The Lempel-Ziv factorization (LZ77) and the Run-Length encoded Burrows-Wheeler Transform (RLBWT) are two important tools in text compression and indexing, being their sizes $z$ and $r$ closely related to the amount of text…

Data Structures and Algorithms · Computer Science 2017-02-07 Alberto Policriti , Nicola Prezza

Protein language models have excelled in a variety of tasks, ranging from structure prediction to protein engineering. However, proteins are highly diverse in functions and structures, and current state-of-the-art models including the…

Biomolecules · Quantitative Biology 2023-02-27 Chang Ma , Haiteng Zhao , Lin Zheng , Jiayi Xin , Qintong Li , Lijun Wu , Zhihong Deng , Yang Lu , Qi Liu , Lingpeng Kong

Database indexes facilitate data retrieval and benefit broad applications in real-world systems. Recently, a new family of index, named learned index, is proposed to learn hidden yet useful data distribution and incorporate such information…

Databases · Computer Science 2021-01-05 Yaliang Li , Daoyuan Chen , Bolin Ding , Kai Zeng , Jingren Zhou

Systematicity, i.e., the ability to recombine known parts and rules to form new sequences while reasoning over relational data, is critical to machine intelligence. A model with strong systematicity is able to train on small-scale tasks and…

Artificial Intelligence · Computer Science 2022-05-16 Shengyao Lu , Bang Liu , Keith G. Mills , Shangling Jui , Di Niu

We introduce a new approach to LZ77 factorization that uses O(n/d) words of working space and O(dn) time for any d >= 1 (for polylogarithmic alphabet sizes). We also describe carefully engineered implementations of alternative approaches to…

Data Structures and Algorithms · Computer Science 2020-12-11 Juha Kärkkäinen , Dominik Kempa , Simon J. Puglisi

It is acknowledged that co-evolutionary nucleotide-nucleotide interactions are essential for RNA structures and functions. Currently, direct coupling analysis (DCA) infers nucleotide contacts in a sequence from its homologous sequence…

Biomolecules · Quantitative Biology 2017-11-30 Yiren Jian , Chen Zeng , Yunjie Zhao

In this paper, we present the design and architecture of REI, a novel system for indexing log data for regular expression queries. Our main contribution is an $n$-gram-based indexing strategy and an efficient storage mechanism that results…

Databases · Computer Science 2025-10-14 Ling Zhang , Shaleen Deep , Jignesh M. Patel , Karthikeyan Sankaralingam