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Predicting protein properties is paramount for biological and medical advancements. Current protein engineering mutates on a typical protein, called the wild-type, to construct a family of homologous proteins and study their properties.…

Machine Learning · Computer Science 2024-06-26 Zhiqiang Zhong , Davide Mottin

Evolutionary and ecosystem dynamics are often treated as different processes --operating at separate timescales-- even if evidence reveals that rapid evolutionary changes can feed back into ecological interactions. A recent long-term field…

Populations and Evolution · Quantitative Biology 2018-10-04 Paula Villa Martín , Jorge Hidalgo , Rafael Rubio de Casas , Miguel A. Muñoz

Persistent homology, a central tool of topological data analysis, provides invariants of data called barcodes (also known as persistence diagrams). A barcode is simply a multiset of real intervals. Recent work of Edelsbrunner, Jablonski,…

Algebraic Topology · Mathematics 2020-10-12 Ulrich Bauer , Michael Lesnick

Machine learning detects patterns, block chain guarantees trust and immutability, and modern causal inference identifies directional linkages, yet none alone exposes the full energetic anatomy of complex systems; the Hamiltonian Higher…

Machine Learning · Computer Science 2025-05-01 Ngueuleweu Tiwang Gildas

Persistent Homology (PH) has been successfully used to train networks to detect curvilinear structures and to improve the topological quality of their results. However, existing methods are very global and ignore the location of topological…

Computer Vision and Pattern Recognition · Computer Science 2022-12-27 Doruk Oner , Adélie Garin , Mateusz Koziński , Kathryn Hess , Pascal Fua

We propose a model that explains the hierarchical organization of proteins in fold families. The model, which is based on the evolutionary selection of proteins by their native state stability, reproduces patterns of amino acids conserved…

Statistical Mechanics · Physics 2007-05-23 Nikolay V. Dokholyan , Eugene I. Shakhnovich

Most complex systems are intrinsically dynamic in nature. The evolution of a dynamic complex system is typically represented as a sequence of snapshots, where each snapshot describes the configuration of the system at a particular instant…

Physics and Society · Physics 2016-12-30 Richard K. Darst , Clara Granell , Alex Arenas , Sergio Gómez , Jari Saramäki , Santo Fortunato

Over the past two decades, complex network theory provided the ideal framework for investigating the intimate relationships between the topological properties characterizing the wiring of connections among a system's unitary components and…

This article aims to study the topological invariant properties encoded in node graph representational embeddings by utilizing tools available in persistent homology. Specifically, given a node embedding representation algorithm, we…

Machine Learning · Computer Science 2021-10-12 Mustafa Hajij , Ghada Zamzmi , Xuanting Cai

A central challenge in topological data analysis is the interpretation of barcodes. The classical algebraic-topological approach to interpreting homology classes is to build maps to spaces whose homology carries semantics we understand and…

Algebraic Topology · Mathematics 2023-08-11 Iris H. R. Yoon , Robert Ghrist , Chad Giusti

0-dimensional persistent homology is known, from a computational point of view, as the easy case. Indeed, given a list of $n$ edges in non-decreasing order of filtration value, one only needs a union-find data structure to keep track of the…

Computational Geometry · Computer Science 2023-12-12 Marc Glisse

The population-based optimization algorithms have provided promising results in feature selection problems. However, the main challenges are high time complexity. Moreover, the interaction between features is another big challenge in FS…

Neural and Evolutionary Computing · Computer Science 2021-10-26 Motahare Namakin , Modjtaba Rouhani , Mostafa Sabzekar

Reticulate evolutionary processes result in phylogenetic histories that cannot be modeled using a tree topology. Here, we apply methods from topological data analysis to molecular sequence data with reticulations. Using a simple example, we…

Quantitative Methods · Quantitative Biology 2015-11-05 Kevin Emmett , Raul Rabadan

In this paper we introduce a statistic, the persistent homology transform (PHT), to model surfaces in $\mathbb{R}^3$ and shapes in $\mathbb{R}^2$. This statistic is a collection of persistence diagrams - multiscale topological summaries…

Statistics Theory · Mathematics 2014-07-16 Katharine Turner , Sayan Mukherjee , Doug M Boyer

Temporal networks of face-to-face interactions between individuals are useful proxies of the dynamics of social systems on fast time scales. Several empirical statistical properties of these networks have been shown to be robust across a…

Physics and Society · Physics 2023-02-03 Didier Le Bail , Mathieu Génois , Alain Barrat

Persistent homology (PH) is a method used in topological data analysis (TDA) to study qualitative features of data that persist across multiple scales. It is robust to perturbations of input data, independent of dimensions and coordinates,…

Algebraic Topology · Mathematics 2017-09-13 Nina Otter , Mason A. Porter , Ulrike Tillmann , Peter Grindrod , Heather A. Harrington

Persistent homology has been studied to better understand the structural properties and topology features of weighted networks. It can reveal hidden layers of information about the higher-order structures formed by non-pairwise interactions…

Combinatorics · Mathematics 2025-06-25 Udit Raj , Slobodan Maletić , Sudeepto Bhattacharya

Persistent homology is a central methodology in topological data analysis that has been successfully implemented in many fields and is becoming increasingly popular and relevant. The output of persistent homology is a persistence diagram --…

Statistics Theory · Mathematics 2024-04-24 Konstantin Häberle , Barbara Bravi , Anthea Monod

Multivariate time series forecasting enables the prediction of future states by leveraging historical data, thereby facilitating decision-making processes. Each data node in a multivariate time series encompasses a sequence of multiple…

Machine Learning · Computer Science 2025-05-02 Xinlong Zhao , Liying Zhang , Tianbo Zou , Yan Zhang

The aim of this paper is to rigorously study dynamics of Heterogeneously Coupled Maps (HCM). Such systems are determined by a network with heterogeneous degrees. Some nodes, called hubs, are very well connected while most nodes interact…

Dynamical Systems · Mathematics 2017-12-20 Tiago Pereira , Sebastian van Strien , Matteo Tanzi