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In evolutionary biology, phylogenetic trees are commonly inferred from a set of characters (partitions) of a collection of biological entities (e.g., species or individuals in a population). Such characters naturally arise from molecular…

Populations and Evolution · Quantitative Biology 2023-11-17 Katharina T. Huber , Simone Linz , Vincent Moulton , Charles Semple

The binary perfect phylogeny model is too restrictive to model biological events such as back mutations. In this paper we consider a natural generalization of the model that allows a special type of back mutation. We investigate the problem…

Data Structures and Algorithms · Computer Science 2012-06-29 Paola Bonizzoni , Chiara Braghin , Riccardo Dondi , Gabriella Trucco

Phylogenetic (i.e. leaf-labeled) trees play a fundamental role in evolutionary research. A typical problem is to reconstruct such trees from data like DNA alignments (whose columns are often referred to as characters), and a simple…

Populations and Evolution · Quantitative Biology 2022-09-08 Mareike Fischer

The perfect phylogeny is one of the most used models in different areas of computational biology. In this paper we consider the problem of the Persistent Perfect Phylogeny (referred as P-PP) recently introduced to extend the perfect…

Data Structures and Algorithms · Computer Science 2014-05-30 Paola Bonizzoni , Anna Paola Carrieri , Gianluca Della Vedova , Gabriella Trucco

The Persistent Perfect phylogeny, also known as Dollo-1, has been introduced as a generalization of the well-known perfect phylogenetic model for binary characters to deal with the potential loss of characters. The problem of deciding the…

Data Structures and Algorithms · Computer Science 2025-07-25 Paola Bonizzoni , Gianluca Della Vedova , Mauricio Soto Gomez , Gabriella Trucco

Recently, the perfect phylogeny model with persistent characters has attracted great attention in the literature. It is based on the assumption that complex traits or characters can only be gained once and lost once in the course of…

Combinatorics · Mathematics 2021-06-08 Remco Bouckaert , Mareike Fischer , Kristina Wicke

One of the main aims of phylogenetics is the reconstruction of the correct evolutionary tree when data concerning the underlying species set are given. These data typically come in the form of DNA, RNA or protein alignments, which consist…

Populations and Evolution · Quantitative Biology 2019-03-22 Mareike Fischer

Perfect phylogenies are fundamental in the study of evolutionary trees because they capture the situation when each evolutionary trait emerges only once in history; if such events are believed to be rare, then by Occam's Razor such…

Discrete Mathematics · Computer Science 2019-04-30 Leo van Iersel , Mark Jones , Steven Kelk

Phylogenetic methods typically rely on an appropriate model of how data evolved in order to infer an accurate phylogenetic tree. For molecular data, standard statistical methods have provided an effective strategy for extracting…

Populations and Evolution · Quantitative Biology 2015-01-21 Robert W. Scotland , Mike Steel

Applying a method to reconstruct a phylogenetic tree from random data provides a way to detect whether that method has an inherent bias towards certain tree `shapes'. For maximum parsimony, applied to a sequence of random 2-state data, each…

Populations and Evolution · Quantitative Biology 2014-06-03 Mareike Fischer , Michelle Galla , Lina Herbst , Mike Steel

Phylogenetic trees are used to model evolution: leaves are labelled to represent contemporary species ("taxa") and interior vertices represent extinct ancestors. Informally, convex characters are measurements on the contemporary species in…

Combinatorics · Mathematics 2021-11-25 Steven Kelk , Ruben Meuwese , Stephan Wagner

Estimating phylogenetic trees, which depict the relationships between different species, from aligned sequence data (such as DNA, RNA, or proteins) is one of the main aims of evolutionary biology. However, tree reconstruction criteria like…

Populations and Evolution · Quantitative Biology 2024-10-02 Mareike Fischer

We study a character-based phylogeny reconstruction problem when an incomplete set of data is given. More specifically, we consider the situation under the directed perfect phylogeny assumption with binary characters in which for some…

Data Structures and Algorithms · Computer Science 2012-03-16 Masashi Kiyomi , Yoshio Okamoto , Toshiki Saitoh

Phylogenetic trees are frequently used to model evolution. Such trees are typically reconstructed from data like DNA, RNA, or protein alignments using methods based on criteria like maximum parsimony (amongst others). Maximum parsimony has…

Populations and Evolution · Quantitative Biology 2023-07-31 Mirko Wilde , Mareike Fischer

Construction of phylogenetic trees and networks for extant species from their characters represents one of the key problems in phylogenomics. While solution to this problem is not always uniquely defined and there exist multiple methods for…

Populations and Evolution · Quantitative Biology 2016-08-10 Nikita Alexeev , Max A. Alekseyev

The Dollo model for reconstructing evolutionary trees from binary characters has been proposed as a generalization of the infinite sites model, also known as the Perfect Phylogeny. In particular, the Dollo model is considered more realistic…

Data Structures and Algorithms · Computer Science 2025-06-17 Paola Bonizzoni , Gianluca Della Vedova , Mauricio Soto Gomez , Gabriella Trucco

Given two phylogenetic trees on the same set of taxa X, the maximum parsimony distance d_MP is defined as the maximum, ranging over all characters c on X, of the absolute difference in parsimony score induced by c on the two trees. In this…

Populations and Evolution · Quantitative Biology 2015-06-23 Olivier Boes , Mareike Fischer , Steven Kelk

The Persistent-Phylogeny Model is an extension of the widely studied Perfect-Phylogeny Model, encompassing a broader range of evolutionary phenomena. Biological and algorithmic questions concerning persistent phylogeny have been intensely…

Populations and Evolution · Quantitative Biology 2015-06-03 Dan Gusfield

Phylogenetically decisive collections of taxon sets have the property that if trees are chosen for each of their elements, as long as these trees are compatible, the resulting supertree is unique. This means that as long as the trees…

Populations and Evolution · Quantitative Biology 2025-05-29 Mareike Fischer , Janne Pott

Finding the most parsimonious tree inside a phylogenetic network with respect to a given character is an NP-hard combinatorial optimization problem that for many network topologies is essentially inapproximable. In contrast, if the network…

Populations and Evolution · Quantitative Biology 2025-01-14 Martin Frohn , Steven Kelk
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