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Motivation: Protein secondary structure prediction can provide important information for protein 3D structure prediction and protein functions. Deep learning, which has been successfully applied to various research fields such as image…

Quantitative Methods · Quantitative Biology 2017-09-20 Chao Fang , Yi Shang , Dong Xu

Large neural networks achieve state-of-the-art performance on many tasks, yet their sheer size hinders deployment on resource-constrained devices. Among existing compression approaches, cross-layer parameter sharing remains relatively…

Machine Learning · Computer Science 2026-05-26 Cem Üyük , Mike Lasby , Mohamed Yassin , Utku Evci , Yani Ioannou

In this paper, we study the problem of semi-supervised structured output prediction, which aims to learn predictors for structured outputs, such as sequences, tree nodes, vectors, etc., from a set of data points of both input-output pairs…

Machine Learning · Computer Science 2016-04-12 Xin Du

In this paper we propose a Bayesian method for estimating architectural parameters of neural networks, namely layer size and network depth. We do this by learning concrete distributions over these parameters. Our results show that regular…

Machine Learning · Statistics 2019-01-29 Georgi Dikov , Patrick van der Smagt , Justin Bayer

Recently, we proposed to transform the outputs of each hidden neuron in a multi-layer perceptron network to have zero output and zero slope on average, and use separate shortcut connections to model the linear dependencies instead. We…

Machine Learning · Computer Science 2013-03-12 Tommi Vatanen , Tapani Raiko , Harri Valpola , Yann LeCun

The expanding scale of large neural network models introduces significant challenges, driving efforts to reduce memory usage and enhance computational efficiency. Such measures are crucial to ensure the practical implementation and…

Machine Learning · Computer Science 2025-02-14 Eduardo Lobo Lustosa Cabral , Larissa Driemeier

This paper addresses the challenges of designing mesh convolution neural networks for 3D mesh dense prediction. While deep learning has achieved remarkable success in image dense prediction tasks, directly applying or extending these…

Computer Vision and Pattern Recognition · Computer Science 2024-08-27 Shi Hezi , Jiang Luo , Zheng Jianmin , Zeng Jun

We propose a generalized convolutional neural network (CNN) architecture that first decomposes the input signal into subbands by an adaptive filter bank structure, and then uses convolutional layers to extract features from each subband…

Image and Video Processing · Electrical Eng. & Systems 2023-06-30 Pavel Sinha , Ioannis Psaromiligkos , Zeljko Zilic

Understanding the relationships between protein sequence, structure and function is a long-standing biological challenge with manifold implications from drug design to our understanding of evolution. Recently, protein language models have…

Quantitative Methods · Quantitative Biology 2024-01-29 Dexiong Chen , Philip Hartout , Paolo Pellizzoni , Carlos Oliver , Karsten Borgwardt

This paper investigates the problem of optimal predictor design for distributed parameter systems using neural networks and shape optimization. Sensors with various shapes are placed on the domain of the distributed parameter system. Data…

Optimization and Control · Mathematics 2021-05-13 M. Sajjad Edalatzadeh , Roland Herzog

This work proposes deep network models and learning algorithms for unsupervised and supervised binary hashing. Our novel network design constrains one hidden layer to directly output the binary codes. This addresses a challenging issue in…

Computer Vision and Pattern Recognition · Computer Science 2016-07-19 Thanh-Toan Do , Anh-Dzung Doan , Ngai-Man Cheung

Despite the considerable success of neural networks in security settings such as malware detection, such models have proved vulnerable to evasion attacks, in which attackers make slight changes to inputs (e.g., malware) to bypass detection.…

Machine Learning · Computer Science 2021-06-09 Netanel Raviv , Aidan Kelley , Michael Guo , Yevgeny Vorobeychik

Deep learning is a machine learning approach that produces excellent performance in various applications, including natural language processing, image identification, and forecasting. Deep learning network performance depends on the…

Machine Learning · Computer Science 2023-06-14 Andri Pranolo , Yingchi Mao , Aji Prasetya Wibawa , Agung Bella Putra Utama , Felix Andika Dwiyanto

Determining the structure of a protein has been a decades-long open question. A protein's three-dimensional structure often poses nontrivial computation costs, when classical simulation algorithms are utilized. Advances in the transformer…

Machine Learning · Computer Science 2023-10-09 Chen Dun , Qiutai Pan , Shikai Jin , Ria Stevens , Mitchell D. Miller , George N. Phillips, , Anastasios Kyrillidis

We introduce a parameter sharing scheme, in which different layers of a convolutional neural network (CNN) are defined by a learned linear combination of parameter tensors from a global bank of templates. Restricting the number of templates…

Machine Learning · Computer Science 2019-03-15 Pedro Savarese , Michael Maire

Learning effective protein representations is critical in a variety of tasks in biology such as predicting protein function or structure. Existing approaches usually pretrain protein language models on a large number of unlabeled amino acid…

Machine Learning · Computer Science 2023-01-31 Zuobai Zhang , Minghao Xu , Arian Jamasb , Vijil Chenthamarakshan , Aurelie Lozano , Payel Das , Jian Tang

Protein secondary structure is crucial to creating an information bridge between the primary and tertiary (3D) structures. Precise prediction of eight-state protein secondary structure (PSS) has significantly utilized in the structural and…

Machine Learning · Computer Science 2020-09-23 Md Aminur Rab Ratul , Maryam Tavakol Elahi , M. Hamed Mozaffari , WonSook Lee

Feedforward multilayer networks trained by supervised learning have recently demonstrated state of the art performance on image labeling problems such as boundary prediction and scene parsing. As even very low error rates can limit…

Computer Vision and Pattern Recognition · Computer Science 2013-12-09 Gary B. Huang , Viren Jain

During the past decade, with the significant progress of computational power as well as ever-rising data availability, deep learning techniques became increasingly popular due to their excellent performance on computer vision problems. The…

Quantitative Methods · Quantitative Biology 2017-07-20 Afshine Amidi , Shervine Amidi , Dimitrios Vlachakis , Vasileios Megalooikonomou , Nikos Paragios , Evangelia I. Zacharaki

Beam search optimization resolves many issues in neural machine translation. However, this method lacks principled stopping criteria and does not learn how to stop during training, and the model naturally prefers the longer hypotheses…

Computation and Language · Computer Science 2019-06-26 Mingbo Ma , Renjie Zheng , Liang Huang
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