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Data lakes are becoming increasingly prevalent for big data management and data analytics. In contrast to traditional 'schema-on-write' approaches such as data warehouses, data lakes are repositories storing raw data in its original formats…

Databases · Computer Science 2023-10-24 Rihan Hai , Christos Koutras , Christoph Quix , Matthias Jarke

The development of vision-language models (VLMs) is driven by large-scale and diverse multimodal datasets. However, progress toward generalist biomedical VLMs is limited by the lack of annotated, publicly accessible datasets across biology…

While many good textbooks are available on Protein Structure, Molecular Simulations, Thermodynamics and Bioinformatics methods in general, there is no good introductory level book for the field of Structural Bioinformatics. This book aims…

Biomolecules · Quantitative Biology 2023-07-10 Jose Gavaldá-Garciá , Bas Stringer , Olga Ivanova , Sanne Abeln , K. Anton Feenstra , Halima Mouhib

A main challenge of data-driven sciences is how to make maximal use of the progressively expanding databases of experimental datasets in order to keep research cumulative. We introduce the idea of a modeling-based dataset retrieval engine…

Quantitative Methods · Quantitative Biology 2015-06-19 Ali Faisal , Jaakko Peltonen , Elisabeth Georgii , Johan Rung , Samuel Kaski

This proceeding covers tools and technologies at our disposal for scientific data preservation and shows that this extends the scientific reach of our experiments. It is cost-efficient to warehouse data from completed experiments on the…

Data Analysis, Statistics and Probability · Physics 2017-12-06 Frank Berghaus

Healthcare sector is totally different from other industry. It is on high priority sector and people expect highest level of care and services regardless of cost. It did not achieve social expectation even though it consume huge percentage…

Computer Vision and Pattern Recognition · Computer Science 2017-04-25 Muhammad Imran Razzak , Saeeda Naz , Ahmad Zaib

Advances in molecular technologies underlie an enormous growth in the size of data sets pertaining to biology and biomedicine. These advances parallel those in the deep learning subfield of machine learning. Components in the differentiable…

Quantitative Methods · Quantitative Biology 2024-06-14 Alex Jihun Lee , Reza Abbasi-Asl

Many of the current scientific advances in the life sciences have their origin in the intensive use of data for knowledge discovery. In no area this is so clear as in bioinformatics, led by technological breakthroughs in data acquisition…

Machine Learning · Computer Science 2018-02-28 Davide Bacciu , Paulo J. G. Lisboa , José D. Martín , Ruxandra Stoean , Alfredo Vellido

Current extragalactic databases are reviewed, including object-oriented databases, astronomical catalogues and compilations, as well as image archives and object catalogues from large-scale surveys. One challenge of the future will be to…

Astrophysics · Physics 2007-05-23 H. Andernach

This short paper gives an introduction to a research project to analyze how digital documents are structured and described. Using a phenomenological approach, this research will reveal common patterns that are used in data, independent from…

Digital Libraries · Computer Science 2014-08-12 Jakob Voß

Large collections of high-dimensional data have become nearly ubiquitous across many academic fields and application domains, ranging from biology to the humanities. Since working directly with high-dimensional data poses challenges, the…

Mathematical models are increasingly used in both academia and the pharmaceutical industry to understand how phenotypes emerge from systems of molecular interactions. However, their current construction as monolithic sets of equations…

Molecular Networks · Quantitative Biology 2007-10-19 Aneil Mallavarapu , Matthew Thomson , Benjamin Ullian , Jeremy Gunawardena

Knowledge bases are prevalent in various domains and have been widely used in a large number of real applications such as applications in online encyclopedia, social media, biomedical fields, bibliographical networks. Due to their great…

Databases · Computer Science 2021-07-09 Feixiang Wang , Yixiang Fang , Yan Song , Shuang Li , Xinyun Chen

In biomedical applications of machine learning, relevant information often has a rich structure that is not easily encoded as real-valued predictors. Examples of such data include DNA or RNA sequences, gene sets or pathways, gene…

Genomics · Quantitative Biology 2019-10-16 Jake Crawford , Casey S. Greene

The explosion of data on the internet is a direct corollary of the social media platform. With petabytes of data being generated by end users, the researchers have access to unprecedented amount of data (Big Data). Such data provides an…

Computers and Society · Computer Science 2019-02-06 Adil E. Rajput , Samara M. Ahmed

Genomic data and biomedical imaging data are undergoing exponential growth. However, our understanding of the phenotype-genotype connection linking the two types of data is lagging behind. While there are many types of software that enable…

Genomics · Quantitative Biology 2013-01-09 Andrew T. Oberlin , Dominika A. Jurkovic , Mitchell F. Balish , Iddo Friedberg

Increasingly sophisticated experiments, coupled with large-scale computational models, have the potential to systematically test biological hypotheses to drive our understanding of multicellular systems. In this short review, we explore key…

Quantitative Methods · Quantitative Biology 2019-10-28 Paul Macklin

Heterogeneous, interconnected, systems-level, molecular data have become increasingly available and key in precision medicine. We need to utilize them to better stratify patients into risk groups, discover new biomarkers and targets,…

Other Quantitative Biology · Quantitative Biology 2024-05-17 Natasa Przulj , Noel Malod-Dognin

Reproducibility is a cornerstone of science, as the replication of findings is the process through which they become knowledge. It is widely considered that many fields of science are undergoing a reproducibility crisis. This has led to the…

Computer Vision and Pattern Recognition · Computer Science 2022-09-13 Olivier Colliot , Elina Thibeau-Sutre , Ninon Burgos

This article highlights some of the basic concepts of bioinformatics and data mining. The major research areas of bioinformatics are highlighted. The application of data mining in the domain of bioinformatics is explained. It also…

Computational Engineering, Finance, and Science · Computer Science 2012-05-08 Khalid Raza