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Generative models for structure-based molecular design hold significant promise for drug discovery, with the potential to speed up the hit-to-lead development cycle, while improving the quality of drug candidates and reducing costs. Data…

Machine Learning · Statistics 2022-04-25 Lucian Chan , Rajendra Kumar , Marcel Verdonk , Carl Poelking

The integration of large language models (LLMs) into robotic systems has accelerated progress in embodied artificial intelligence, yet current approaches remain constrained by existing robotic architectures, particularly serial mechanisms.…

Robotics · Computer Science 2025-10-07 Guanglu Jia , Ceng Zhang , Gregory S. Chirikjian

Current flight procedure design methods heavily rely on human-led design process, which is not only low auto-mation but also suffer from complex algorithm modelling and poor generalization. To address these challenges, this paper proposes…

Artificial Intelligence · Computer Science 2024-10-22 Longtao Zhu , Hongyu Yang , Ge Song , Xin Ma , Yanxin Zhang , Yulong Ji

Language models (LMs) built upon deep neural networks (DNNs) have recently demonstrated breakthrough effectiveness in software engineering tasks such as code generation, completion, and repair. This has paved the way for the emergence of…

Software Engineering · Computer Science 2025-01-06 Jingzhi Gong , Vardan Voskanyan , Paul Brookes , Fan Wu , Wei Jie , Jie Xu , Rafail Giavrimis , Mike Basios , Leslie Kanthan , Zheng Wang

The design or the optimization of transport systems is a difficult task. This is especially true in the case of the introduction of new transport modes in an existing system. The main reason is, that even small additions and changes result…

Multiagent Systems · Computer Science 2023-07-28 Sebastian Brulin , Markus Olhofer

Precision motion stages are an essential part of a wide range of manufacturing equipment, and their motion performance are critical to the quality and throughput of the systems. The drastically increasing demand for higher manufacturing…

Systems and Control · Electrical Eng. & Systems 2022-02-17 Jingjie Wu , Lei Zhou

We model, simulate and control the guiding problem for a herd of evaders under the action of repulsive drivers. The problem is formulated in an optimal control framework, where the drivers (controls) aim to guide the evaders (states) to a…

Optimization and Control · Mathematics 2020-05-01 Dongnam Ko , Enrique Zuazua

The operation of multirotors in crowded environments requires a highly reliable takeoff method, as failures during takeoff can damage more valuable assets nearby. The addition of a ballistic launch system imposes a deterministic path for…

Systems and Control · Electrical Eng. & Systems 2020-03-19 Daniel Pastor , Jacob Izraelevitz , Paul Nadan , Amanda Bouman , Joel Burdick , Brett Kennedy

Microstructures, characterized by intricate structures at the microscopic scale, hold the promise of important disruptions in the field of mechanical engineering due to the superior mechanical properties they offer. One fundamental…

Computational Geometry · Computer Science 2024-11-26 Qiang Zou , Guoyue Luo

Generative systems have a significant potential to synthesize innovative design alternatives. Still, most of the common systems that have been adopted in design require the designer to explicitly define the specifications of the procedures…

Machine Learning · Computer Science 2019-04-03 Ardavan Bidgoli , Pedro Veloso

This article presents a new control approach and a dynamic model for engineered flapping flight with many interacting degrees of freedom. This paper explores the applications of neurobiologically inspired control systems in the form of…

Optimization and Control · Mathematics 2011-08-05 Soon-Jo Chung , Michael Dorothy

This paper presents an integrated lander-propulsion-GNC framework for autonomous lunar powered descent. The BUG VTVL test vehicle serves as the reference platform, with the YUNT V0 throttleable bipropellant engine providing variable thrust…

Systems and Control · Electrical Eng. & Systems 2026-04-28 Emre Aklan , Fatih Seker , Bekir Gencalioglu , Mehmet Batuhan Kaya , Yigit Serceoglu , Furkan Yavuz , Omer Burak Iskender , Burak Yaglioglu

Studies on manufacturing cost prediction based on deep learning have begun in recent years, but the cost prediction rationale cannot be explained because the models are still used as a black box. This study aims to propose a manufacturing…

Computational Geometry · Computer Science 2022-10-04 Soyoung Yoo , Namwoo Kang

Modular product design has become a strategic enabler for companies seeking to balance product variety, operational efficiency, and market responsiveness, making the alignment between modular architecture and manufacturing considerations…

Systems and Control · Electrical Eng. & Systems 2025-10-14 Fabio Marco Monetti , Adam Lundström , Colin de Kwant , Magnus Gyllenskepp , Antonio Maffei

Model-based process simulation can be used to derive designs and operating conditions of chemical processes that optimally balance multiple objectives, such as quality, costs, or environmental impacts. This work focuses on identifying…

The high energy consumption of electronic data processors, together with physical challenges limiting their further improvement, has triggered intensive interest in alternative computation paradigms. Here we focus on network-based…

Computing the receding horizon optimal control of nonlinear hybrid systems is typically prohibitively slow, limiting real-time implementation. To address this challenge, we propose a layered Model Predictive Control (MPC) architecture for…

Systems and Control · Electrical Eng. & Systems 2025-03-18 Zachary Olkin , Aaron D. Ames

In this study, we formulate the drone delivery problem as a control problem and solve it using Model Predictive Control. Two experiments are performed: The first is on a less challenging grid world environment with lower dimensionality, and…

Artificial Intelligence · Computer Science 2025-03-26 Muhammad Al-Zafar Khan , Jamal Al-Karaki

Systems tend to become more and more complex. This has a direct impact on system engineering processes. Two of the most important phases in these processes are requirements engineering and quality assurance. Two significant complexity…

Software Engineering · Computer Science 2013-03-06 Stephan Weißleder , Hartmut Lackner

On-chip mode-division multiplexing (MDM) has been emerging as a promising technology to further enhance the link capacity and bandwidth of data communications with multiple mode channels. Both mode converters and mode exchangers are…

Optics · Physics 2020-07-16 Jinlong Xiang , Zhiyuan Tao , Xuhan Guo , Yong Zhang , Yaotian Zhao , Yikai Su