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Since survival data occur over time, often important covariates that we wish to consider also change over time. Such covariates are referred as time-dependent covariates. Quantile regression offers flexible modeling of survival data by…

Methodology · Statistics 2014-05-01 Malka Gorfine , Yair Goldberg , Yaacov Ritov

Time elapsed till an event of interest is often modeled using the survival analysis methodology, which estimates a survival score based on the input features. There is a resurgence of interest in developing more accurate prediction models…

Machine Learning · Computer Science 2024-07-23 Navid Seidi , Ardhendu Tripathy , Sajal K. Das

Linear approximations to the decision boundary of a complex model have become one of the most popular tools for interpreting predictions. In this paper, we study such linear explanations produced either post-hoc by a few recent methods or…

Machine Learning · Computer Science 2018-01-31 Maruan Al-Shedivat , Avinava Dubey , Eric P. Xing

The spatial distributions of different types of cells could reveal a cancer cell growth pattern, its relationships with the tumor microenvironment and the immune response of the body, all of which represent key hallmarks of cancer. However,…

Computer Vision and Pattern Recognition · Computer Science 2018-09-28 Shidan Wang , Tao Wang , Lin Yang , Faliu Yi , Xin Luo , Yikun Yang , Adi Gazdar , Junya Fujimoto , Ignacio I. Wistuba , Bo Yao , ShinYi Lin , Yang Xie , Yousheng Mao , Guanghua Xiao

Modeling the time-series of high-dimensional, longitudinal data is important for predicting patient disease progression. However, existing neural network based approaches that learn representations of patient state, while very flexible, are…

Machine Learning · Computer Science 2021-06-21 Zeshan Hussain , Rahul G. Krishnan , David Sontag

Predicting the likelihood of survival is of paramount importance for individuals diagnosed with cancer as it provides invaluable information regarding prognosis at an early stage. This knowledge enables the formulation of effective…

Computer Vision and Pattern Recognition · Computer Science 2024-03-19 Numan Saeed , Muhammad Ridzuan , Fadillah Adamsyah Maani , Hussain Alasmawi , Karthik Nandakumar , Mohammad Yaqub

Cancer prognostication is a challenging task in computational pathology that requires context-aware representations of histology features to adequately infer patient survival. Despite the advancements made in weakly-supervised deep…

Image and Video Processing · Electrical Eng. & Systems 2021-07-29 Richard J. Chen , Ming Y. Lu , Muhammad Shaban , Chengkuan Chen , Tiffany Y. Chen , Drew F. K. Williamson , Faisal Mahmood

The Weibull distribution is a commonly adopted choice for modeling the survival of systems subject to maintenance over time. When only proxy indicators and censored observations are available, it becomes necessary to express the…

Machine Learning · Statistics 2025-12-11 Gabrielle Rives , Olivier Lopez , Nicolas Bousquet

Many applications involve reasoning about time durations before a critical event happens--also called time-to-event outcomes. When will a customer cancel a subscription, a coma patient wake up, or a convicted criminal reoffend?…

Machine Learning · Statistics 2024-10-03 George H. Chen

We consider Bayesian hierarchical models for survival analysis, where the survival times are modeled through an underlying diffusion process which determines the hazard rate. We show how these models can be efficiently treated by means of…

Statistics Theory · Mathematics 2010-10-11 Gareth O. Roberts , Laura M. Sangalli

We emphasize the importance of asking the right question when interpreting the decisions of a learning model. We discuss a natural extension of the theoretical machinery from Janzing et. al. 2020, which answers the question "Why did my…

Machine Learning · Statistics 2020-12-11 Debraj Basu

Over time, the performance of clinical prediction models may deteriorate due to changes in clinical management, data quality, disease risk and/or patient mix. Such prediction models must be updated in order to remain useful. Here, we…

Survival prediction is an important branch of cancer prognosis analysis. The model that predicts survival risk through TCGA genomics data can discover genes related to cancer and provide diagnosis and treatment recommendations based on…

Machine Learning · Computer Science 2024-05-14 Wankang Zhai

We propose a method to quantify uncertainty around individual survival distribution estimates using right-censored data, compatible with any survival model. Unlike classical confidence intervals, the survival bands produced by this method…

Methodology · Statistics 2025-12-18 Matteo Sesia , Vladimir Svetnik

Survival analysis concerns the task of predicting the time until an event occurs. Often used in the medical field, survival analysis deals with incomplete (i.e., censored) data, for instance, from patients who did not experience the event…

Machine Learning · Computer Science 2026-05-29 Thalea Schlender , Peter A. N. Bosman , Tanja Alderliesten

In this paper, we present a probabilistic analysis of a dynamical particle model for the self-adaptive immune response to cancer, as proposed by the first author in a previous work. The model is motivated by the interplay between immune…

Probability · Mathematics 2025-08-06 Christian Kuehn , Quirin Vogel

Breast cancer remains a significant global health challenge, with prognosis and treatment decisions largely dependent on clinical characteristics. Accurate prediction of patient outcomes is crucial for personalized treatment strategies.…

Time series data is prevalent in a wide variety of real-world applications and it calls for trustworthy and explainable models for people to understand and fully trust decisions made by AI solutions. We consider the problem of building…

Machine Learning · Computer Science 2020-11-25 Tsung-Yu Hsieh , Suhang Wang , Yiwei Sun , Vasant Honavar

Accurate survival prediction is crucial for development of precision cancer medicine, creating the need for new sources of prognostic information. Recently, there has been significant interest in exploiting routinely collected clinical and…

Machine Learning · Computer Science 2021-03-23 Sejin Kim , Michal Kazmierski , Benjamin Haibe-Kains

Graphical models have gained a lot of attention recently as a tool for learning and representing dependencies among variables in multivariate data. Often, domain scientists are looking specifically for differences among the dependency…

Machine Learning · Statistics 2013-07-11 Diane Oyen , Alexandru Niculescu-Mizil , Rachel Ostroff , Alex Stewart , Vincent P. Clark