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We describe the theoretical and computational framework for the Dynamic Signatures for Genetic Regulatory Network (DSGRN) database. The motivation stems from urgent need to understand the global dynamics of biologically relevant signal…

Dynamical Systems · Mathematics 2015-12-15 Bree Cummins , Tomas Gedeon , Shaun Harker , Konstantin Mischaikow , Kafung Mok

In this paper we describe a combined combinatorial/numerical approach to studying equilibria and bifurcations in network models arising in Systems Biology. ODE models of the dynamics suffer from high dimensional parameters which presents a…

Dynamical Systems · Mathematics 2024-11-28 Shane Kepley , Konstantin Mischaikow , Elena Queirolo

Understanding how the structure of within-system interactions affects the dynamics of the system is important in many areas of science. We extend a network dynamics modeling platform DSGRN, which combinatorializes both dynamics and…

Dynamical Systems · Mathematics 2022-05-17 Bree Cummins , Marcio Gameiro , Tomas Gedeon , Shane Kepley , Konstantin Mischaikow , Lun Zhang

Learning continuous-time dynamics on complex networks is crucial for understanding, predicting and controlling complex systems in science and engineering. However, this task is very challenging due to the combinatorial complexities in the…

Social and Information Networks · Computer Science 2020-06-19 Chengxi Zang , Fei Wang

We introduce a combinatorial topological framework for characterizing the global dynamics of ordinary differential equations (ODEs). The approach is motivated by the study of gene regulatory networks, which are often modeled by ODEs that…

Time-continuous dynamical systems defined on graphs are often used to model complex systems with many interacting components in a non-spatial context. In the reverse sense attaching meaningful dynamics to given 'interaction diagrams' is a…

Molecular Networks · Quantitative Biology 2010-07-02 Markus Kirkilionis , Luca Sbano

Representation learning on dynamic graphs requires capturing complex dependencies that evolve across both time and structure. Existing approaches typically adopt fixed temporal decay schemes or predetermined structural propagation depths,…

Machine Learning · Computer Science 2026-05-29 Qian Chang , Ciprian Doru Giurcaneanu , Runsong Jia , Xia Li , Guoping Hu , Xiufeng Cheng , Jinqing Yang , Mengjia Wu , Yi Zhang

In spite of the recent interest and advances in linear controllability of complex networks, controlling nonlinear network dynamics remains to be an outstanding problem. We develop an experimentally feasible control framework for nonlinear…

Molecular Networks · Quantitative Biology 2015-09-24 Le-Zhi Wang , Ri-Qi Su , Zi-Gang Huang , Xiao Wang , Wenxu Wang , Celso Grebogi , Ying-Cheng Lai

This paper presents an algorithm for approximating certain types of dynamical systems given by a system of ordinary delay differential equations by a Boolean network model. Often Boolean models are much simpler to understand than complex…

Molecular Networks · Quantitative Biology 2011-05-10 Franziska Hinkelmann , Reinhard Laubenbacher

A dynamic graph (DG) is frequently encountered in numerous real-world scenarios. Consequently, A dynamic graph convolutional network (DGCN) has been successfully applied to perform precise representation learning on a DG. However,…

Machine Learning · Computer Science 2025-04-23 Minglian Han

The analysis of global dynamics, particularly the identification and characterization of attractors and their regions of attraction, is essential for complex nonlinear and hybrid systems. Combinatorial methods based on Conley's index theory…

Dynamical Systems · Mathematics 2025-11-13 Bernardo Rivas , Kaito Iwasaki , William Kalies , Anthony Bloch , Maani Ghaffari

Many real-world systems, such as moving planets, can be considered as multi-agent dynamic systems, where objects interact with each other and co-evolve along with the time. Such dynamics is usually difficult to capture, and understanding…

Machine Learning · Computer Science 2020-11-10 Zijie Huang , Yizhou Sun , Wei Wang

Dynamic networks models describe a growing number of important scientific processes, from cell biology and epidemiology to sociology and finance. There are many aspects of dynamical networks that require statistical considerations. In this…

Methodology · Statistics 2012-05-15 E. C. Wit , A. Abbruzzo

We propose a simple adaptive-network model describing recent swarming experiments. Exploiting an analogy with human decision making, we capture the dynamics of the model by a low-dimensional system of equations permitting analytical…

Disordered Systems and Neural Networks · Physics 2011-07-15 Cristián Huepe , Gerd Zschaler , Anne-Ly Do , Thilo Gross

Dynamic Bayesian networks (DBNs) are a widely used framework for modeling systems whose probabilistic structure evolves over time. Standard inference methods focus on local conditional distributions and can miss larger-scale patterns in how…

Algebraic Topology · Mathematics 2026-05-13 Will Bales , Carmen Rovi

Many different classification tasks need to manage structured data, which are usually modeled as graphs. Moreover, these graphs can be dynamic, meaning that the vertices/edges of each graph may change during time. Our goal is to jointly…

Machine Learning · Computer Science 2019-08-20 Franco Manessi , Alessandro Rozza , Mario Manzo

Count-weighted temporal networks often exhibit unequal dispersion in the edge weights, which cannot be fully explained by modelling observational heterogeneity through latent factors in the conditional mean. Therefore, we propose new…

Methodology · Statistics 2026-04-15 Giulia Carallo , Roberto Casarin , Antonio Peruzzi

Identifying causal relations among multi-variate time series is one of the most important elements towards understanding the complex mechanisms underlying the dynamic system. It provides critical tools for forecasting, simulations and…

Machine Learning · Computer Science 2023-02-22 Yang Sun , Yifan Xie

Traffic forecasting is a problem of intelligent transportation systems (ITS) and crucial for individuals and public agencies. Therefore, researches pay great attention to deal with the complex spatio-temporal dependencies of traffic system…

Machine Learning · Computer Science 2021-12-07 Yanjun Qin , Yuchen Fang , Haiyong Luo , Fang Zhao , Chenxing Wang

This research addresses the problem of adaptive modeling in time-series data streams with clear input-output relationships. This problem is challenging because rapid system changes (regime shifts) caused by environmental factors or input…

Machine Learning · Computer Science 2026-05-27 Ren Fujiwara , Yasuko Matsubara , Yasushi Sakurai
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