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Despite the increasing prevalence of vector observations, computation of optimal experimental design for multi-response models has received limited attention. To address this problem within the framework of approximate designs, we introduce…

Computation · Statistics 2026-02-13 Pál Somogyi , Samuel Rosa , Radoslav Harman

In optimal experimental design, the objective is to select a limited set of experiments that maximizes information about unknown model parameters based on factor levels. This work addresses the generalized D-optimal design problem, allowing…

Data Structures and Algorithms · Computer Science 2024-11-05 Aditya Pillai , Gabriel Ponte , Marcia Fampa , Jon Lee , and Mohit Singh , Weijun Xie

Recent advances in data collection technologies have led to the emergence of massive spatial datasets, with measurements obtained at millions of spatial locations. Geostatistical models typically employ Gaussian processes (GPs) to capture…

Methodology · Statistics 2026-05-18 Nicholas Rios , Ben Seiyon Lee

In this paper, we propose two simple yet efficient computational algorithms to obtain approximate optimal designs for multi-dimensional linear regression on a large variety of design spaces. We focus on the two commonly used optimal…

Statistics Theory · Mathematics 2021-02-26 Jiangtao Duan , Wei Gao , Yanyuan Ma , Hon Keung Tony Ng

The theory of optimal design of experiments has been traditionally developed on an Euclidean space. In this paper, new theoretical results and an algorithm for finding the optimal design of an experiment located on a Riemannian manifold are…

Statistics Theory · Mathematics 2023-02-03 Hang Li , Enrique Del Castillo

Consider an experiment with a finite set of design points representing permissible trial conditions. Suppose that each trial is associated with a cost that depends on the selected design point. In this paper, we study the problem of…

Computation · Statistics 2014-08-13 Radoslav Harman , Eva Benková

The coordinate-exchange algorithm is commonly used to construct optimal experimental designs. Every execution of the coordinate-exchange algorithm produces a new, seemingly random, order of the selected design points. In this short…

Methodology · Statistics 2026-03-24 Arno Strouwen , Peter Goos

Motivated by economic dispatch and linearly-constrained resource allocation problems, this paper proposes a novel Distributed Approx-Newton algorithm that approximates the standard Newton optimization method. A main property of this…

Numerical Analysis · Computer Science 2017-03-24 Tor Anderson , Chin-Yao Chang , Sonia Martinez

Nowadays, in many different fields, massive data are available and for several reasons, it might be convenient to analyze just a subset of the data. The application of the D-optimality criterion can be helpful to optimally select a…

Methodology · Statistics 2022-08-15 L. Deldossi , E. Pesce , C. Tommasi

Experimental design is a classical statistics problem and its aim is to estimate an unknown $m$-dimensional vector $\beta$ from linear measurements where a Gaussian noise is introduced in each measurement. For the combinatorial experimental…

Machine Learning · Statistics 2024-12-06 Mohit Singh , Weijun Xie

Systems with both quantitative and qualitative responses are widely encountered in many applications. Design of experiment methods are needed when experiments are conducted to study such systems. Classic experimental design methods are…

Methodology · Statistics 2023-04-24 Lulu Kang , Xinwei Deng , Ran Jin

We describe the R package acebayes and demonstrate its use to find Bayesian optimal experimental designs. A decision-theoretic approach is adopted, with the optimal design maximising an expected utility. Finding Bayesian optimal designs for…

Computation · Statistics 2018-12-27 Antony Overstall , David Woods , Maria Adamou

Efficient computational methods that are capable of supporting experimental measures obtained at constant values of pH and redox potential are important tools as they serve to, among other things, provide additional atomic level information…

Chemical Physics · Physics 2018-09-21 Vinícius Wilian D. Cruzeiro , Adrian E. Roitberg

The construction of decision-theoretic Bayesian designs for realistically-complex nonlinear models is computationally challenging, as it requires the optimization of analytically intractable expected utility functions over high-dimensional…

Methodology · Statistics 2016-07-01 Antony Overstall , David Woods

A simple yet efficient computational algorithm for computing the continuous optimal experimental design for linear models is proposed. An alternative proof the monotonic convergence for $D$-optimal criterion on continuous design spaces are…

Computation · Statistics 2018-04-10 Jiangtao Duan , Wei Gao , Hon Keung Tony Ng

Replica exchange (REX) is one of the most widely used enhanced sampling methodologies, yet its efficiency is limited by the requirement for a large number of intermediate temperature replicas. Here we present Generative Replica Exchange…

Biomolecules · Quantitative Biology 2026-03-20 Shengjie Huang , Sijie Yang , Jianqiao Yi , Rui Zheng , Haocong Liao , Muzammal Hussain , Yaoquan Tu , Xiaoyun Lu , Yang Zhou

The replica exchange method is a powerful tool for overcoming slow relaxation in molecular simulations, but its efficiency depends strongly on the choice of the number and interval of replicas and their exchange probabilities. Here, we…

Statistical Mechanics · Physics 2025-06-04 Akie Kowaguchi , Katsuhiro Endo , Kentaro Nomura , Shuichi Kurabayashi , Paul E. Brumby , Kenji Yasuoka

We propose a method for analyzing the distributed random coordinate descent algorithm for solving separable resource allocation problems in the context of an open multiagent system, where agents can be replaced during the process. In…

Multiagent Systems · Computer Science 2023-09-21 Charles Monnoyer de Galland , Renato Vizuete , Julien M. Hendrickx , Elena Panteley , Paolo Frasca

Finding a maximum cut is a fundamental task in many computational settings. Surprisingly, it has been insufficiently studied in the classic distributed settings, where vertices communicate by synchronously sending messages to their…

Data Structures and Algorithms · Computer Science 2017-07-27 Keren Censor-Hillel , Rina Levy , Hadas Shachnai

Replica exchange (RE) is one of the most popular enhanced-sampling simulations technique in use today. Despite widespread successes, RE simulations can sometimes fail to converge in practical amounts of time, e.g., when sampling around…

Statistical Mechanics · Physics 2021-05-13 Thomas Vogel , Danny Perez
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