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Regenerating codes allow distributed storage systems to recover from the loss of a storage node while transmitting the minimum possible amount of data across the network. We present a systematic computer search for optimal systematic…

Information Theory · Computer Science 2009-10-14 Daniel Cullina , Alexandros G. Dimakis , Tracey Ho

Motivated by applications to DNA storage, we study reconstruction and list-reconstruction schemes for integer vectors that suffer from limited-magnitude errors. We characterize the asymptotic size of the intersection of error balls in…

Information Theory · Computer Science 2021-08-24 Hengjia Wei , Moshe Schwartz

We consider the problem of constructing an erasure code for storage over a network when the data sources are distributed. Specifically, we assume that there are n storage nodes with limited memory and k<n sources generating the data. We…

Information Theory · Computer Science 2016-11-15 Alexandros G. Dimakis , Vinod Prabhakaran , Kannan Ramchandran

The emerging field of DNA storage employs strands of DNA bases (A/T/C/G) as a storage medium for digital information to enable massive density and durability. The DNA storage pipeline includes: (1) encoding the raw data into sequences of…

Genomics · Quantitative Biology 2025-01-28 Hadas Abraham , Barak Gahtan , Adir Kobovich , Orian Leitersdorf , Alex M. Bronstein , Eitan Yaakobi

DNA storage has matured from concept to practical stage, yet its integration with neural compression pipelines remains inefficient. Early DNA encoders applied redundancy-heavy constraint layers atop raw binary data - workable but primitive.…

Machine Learning · Computer Science 2026-02-09 Cihan Ruan , Lebin Zhou , Rongduo Han , Linyi Han , Bingqing Zhao , Chenchen Zhu , Wei Jiang , Wei Wang , Nam Ling

DNA has been considered a promising medium for storing digital information. As an essential step in the DNA-based data storage workflow, coding algorithms are responsible to implement functions including bit-to-base transcoding, error…

Emerging Technologies · Computer Science 2023-03-31 Haoling Zhang , Zhaojun Lan , Wenwei Zhang , Xun Xu , Zhi Ping , Yiwei Zhang , Yue Shen

Current research on DNA storage usually focuses on the improvement of storage density by developing effective encoding and decoding schemes while lacking the consideration on the uncertainty in ultra-long-term data storage and retention.…

Emerging Technologies · Computer Science 2022-08-10 Min Li , Jiashu Wu , Junbiao Dai , Qingshan Jiang , Qiang Qu , Xiaoluo Huang , Yang Wang

We describe the first DNA-based storage architecture that enables random access to data blocks and rewriting of information stored at arbitrary locations within the blocks. The newly developed architecture overcomes drawbacks of existing…

Information Theory · Computer Science 2015-05-12 S. M. Hossein Tabatabaei Yazdi , Yongbo Yuan , Jian Ma , Huimin Zhao , Olgica Milenkovic

Digital information can be encoded in the building-block sequence of macro-molecules, such as RNA and single-stranded DNA. Methods of "writing" and "reading" macromolecular strands are currently available, but they are slow and expensive.…

Emerging Technologies · Computer Science 2017-09-14 Masud Mansuripur , Pramod Khulbe

In this paper, we consider the problem of designing DNA sequences (codewords) for DNA storage systems and DNA computing that are unlikely to fold back onto themselves to form undesirable secondary structures. The paper addresses both the…

Discrete Mathematics · Computer Science 2016-11-17 Olgica Milenkovic , Navin Kashyap

We consider the problem of designing low-redundancy codes in settings where one must correct deletions in conjunction with substitutions or adjacent transpositions; a combination of errors that is usually observed in DNA-based data storage.…

Information Theory · Computer Science 2021-12-21 Ryan Gabrys , Venkatesan Guruswami , João Ribeiro , Ke Wu

Error-correcting codes are a method for representing data, so that one can recover the original information even if some parts of it were corrupted. The basic idea, which dates back to the revolutionary work of Shannon and Hamming about a…

Information Theory · Computer Science 2026-03-05 Mrinal Kumar , Noga Ron-Zewi

Encoding data structures store enough information to answer the queries they are meant to support but not enough to recover their underlying datasets. In this paper we give the first encoding data structure for the challenging problem of…

Data Structures and Algorithms · Computer Science 2017-02-21 Travis Gagie , Giovanni Manzini , Rossano Venturini

Storing data in DNA is being explored as an efficient solution for archiving and in-object storage. Synthesis time and cost remain challenging, significantly limiting some applications at this stage. In this paper we investigate efficient…

Information Theory · Computer Science 2024-12-10 Amit Zrihan , Eitan Yaakobi , Zohar Yakhini

DNA data storage is rapidly emerging as a promising solution for long-term data archiving, largely due to its exceptional durability. However, the synthesis of DNA strands remains a significant bottleneck in terms of cost and speed. To…

Other Computer Science · Computer Science 2025-07-11 Parv Agarwal , Nimesh Pinnamaneni , Thomas Heinis

Tandem duplication is the process of inserting a copy of a segment of DNA adjacent to the original position. Motivated by applications that store data in living organisms, Jain et al. (2017) proposed the study of codes that correct tandem…

Information Theory · Computer Science 2018-01-09 Yeow Meng Chee , Johan Chrisnata , Han Mao Kiah , Tuan Thanh Nguyen

As a possible implementation of data storage using DNA, multiple strands of DNA are stored in a liquid container so that, in the future, they can be read by an array of DNA readers in parallel. These readers will sample the strands with…

Information Theory · Computer Science 2024-09-04 Hsin-Po Wang , Venkatesan Guruswami

Maximum run-length limited codes are constraint codes used in communication and data storage systems. Insertion/deletion correcting codes correct insertion or deletion errors caused in transmitted sequences and are used for combating…

Information Theory · Computer Science 2020-12-29 Reona Takemoto , Takayuki Nozaki

The persistent storage of big data requires advanced error correction schemes. The classical approach is to use error correcting codes (ECCs). This work studies an alternative approach, which uses the redundancy inherent in data itself for…

Information Theory · Computer Science 2019-10-17 Pulakesh Upadhyaya , Anxiao Jiang

Distributed storage systems provide reliable access to data through redundancy spread over individually unreliable nodes. Application scenarios include data centers, peer-to-peer storage systems, and storage in wireless networks. Storing…

Networking and Internet Architecture · Computer Science 2008-03-06 Alexandros G. Dimakis , P. Brighten Godfrey , Yunnan Wu , Martin J. Wainwright , Kannan Ramchandran