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DNA storage is a promising archival data storage solution to today's big data problem. A DNA storage system encodes and stores digital data with synthetic DNA sequences and decodes DNA sequences back to digital data via sequencing. For…

Emerging Technologies · Computer Science 2024-03-22 Yixun Wei , Wenlong Wang , Huibing Dong , Bingzhe Li , David Du

The main obstacles for the practical deployment of DNA-based data storage platforms are the prohibitively high cost of synthetic DNA and the large number of errors introduced during synthesis. In particular, synthetic DNA products contain…

Image and Video Processing · Electrical Eng. & Systems 2021-01-26 Chao Pan , S. M. Hossein Tabatabaei Yazdi , S Kasra Tabatabaei , Alvaro G. Hernandez , Charles Schroeder , Olgica Milenkovic

Deoxyribonucleic acid (DNA) has shown great promise in enabling computational applications, most notably in the fields of DNA digital data storage and DNA computing. Information is encoded as DNA strands, which will naturally bind in…

Machine Learning · Computer Science 2021-10-22 David Buterez

While achieving a compression ratio of 2.0 bits/base, the new algorithm codes non-N bases in fixed length. It dramatically reduces the time of coding and decoding than previous DNA compression algorithms and some universal compression…

Information Theory · Computer Science 2007-07-16 Jie Liu , Sheng Bao , Zhiqiang Jing , Shi Chen

We present a finite blocklength performance bound for a DNA storage channel with insertions, deletions, and substitutions. The considered bound -- the dependency testing (DT) bound, introduced by Polyanskiy et al. in 2010 -- provides an…

Information Theory · Computer Science 2023-08-07 Issam Maarouf , Gianluigi Liva , Eirik Rosnes , Alexandre Graell i Amat

Composite DNA is a recent novel method to increase the information capacity of DNA-based data storage above the theoretical limit of 2 bits/symbol. In this method, every composite symbol does not store a single DNA nucleotide but a mixture…

Information Theory · Computer Science 2025-01-22 Tuan Thanh Nguyen , Chen Wang , Kui Cai , Yiwei Zhang , Zohar Yakhini

Because of its high data density and longevity, DNA is emerging as a promising candidate for satisfying increasing data storage needs. Compared to conventional storage media, however, data stored in DNA is subject to a wider range of errors…

Information Theory · Computer Science 2020-08-20 Yuanyuan Tang , Farzad Farnoud

Codes have been used for centuries to convey secret information.To a cryptanalyst, the interception of a code is only the first step in recovering a secret message.Deoxyribonucleic acid (DNA) is a biological and molecular code.Through the…

Cryptography and Security · Computer Science 2008-01-31 O. Okunoye Babatunde

Deoxyribonucleic Acid (DNA) as a storage medium with high density and long-term preservation properties can satisfy the requirement of archival storage for rapidly increased digital volume. The read and write processes of DNA storage are…

Emerging Technologies · Computer Science 2021-06-01 Bingzhe Li , Li Ou , David Du

Synthesis of DNA molecules offers unprecedented advances in storage technology. Yet, the microscopic world in which these molecules reside induces error patterns that are fundamentally different from their digital counterparts. Hence, to…

Information Theory · Computer Science 2017-08-08 Netanel Raviv , Moshe Schwartz , Eitan Yaakobi

We live in a period where bio-informatics is rapidly expanding, a significant quantity of genomic data has been produced as a result of the advancement of high-throughput genome sequencing technology, raising concerns about the costs…

Quantitative Methods · Quantitative Biology 2023-03-10 Mehedi Hasan Sarkar , Adnan Ferdous Ashrafi

This paper introduces a new family of reconstruction codes which is motivated by applications in DNA data storage and sequencing. In such applications, DNA strands are sequenced by reading some subset of their substrings. While previous…

Information Theory · Computer Science 2022-05-10 Yonatan Yehezkeally , Daniella Bar-Lev , Sagi Marcovich , Eitan Yaakobi

DNA-based data storage systems face practical challenges due to the high cost of DNA synthesis. A strategy to address the problem entails encoding data via topological modifications of the DNA sugar-phosphate backbone. The DNA Punchcards…

Emerging Technologies · Computer Science 2025-05-07 Jin Sima , Chao Pan , S. Kasra Tabatabaei , Alvaro G. Hernandez , Charles M. Schroeder , Olgica Milenkovic

The problem of storing large amounts of information safely for a long period of time has become essential. One of the most promising new data storage mediums are the polymer-based data storage systems, like the DNA-storage system. These…

Information Theory · Computer Science 2025-04-21 Ville Junnila , Tero Laihonen , Tuomo Lehtilä

An indel refers to a single insertion or deletion, while an edit refers to a single insertion, deletion or substitution. In this paper, we investigate codes that combat either a single indel or a single edit and provide linear-time…

Information Theory · Computer Science 2019-10-16 Kui Cai , Yeow Meng Chee , Ryan Gabrys , Han Mao Kiah , Tuan Thanh Nguyen

DNA storage has emerged as an important area of research. The reliability of DNA storage system depends on designing the DNA strings (called DNA codes) that are sufficiently dissimilar. In this work, we introduce DNA codes that satisfy a…

Information Theory · Computer Science 2022-11-28 Krishna Gopal Benerjee , Sourav Deb , Manish K Gupta

Ternary channels can be used to model the behavior of some memory devices, where information is stored in three different levels. In this paper, error correcting coding for a ternary channel where some of the error transitions are not…

Information Theory · Computer Science 2011-05-31 Nicolas Bitouze , Alexandre Graell i Amat , Eirik Rosnes

We describe properties and constructions of constraint-based codes for DNA-based data storage which account for the maximum repetition length and AT/GC balance. We present algorithms for computing the number of sequences with maximum…

Information Theory · Computer Science 2018-12-18 Kees A. Schouhamer Immink , Kui Cai

The exponentially increasing demand for data storage has been facing more and more challenges during the past years. The energy costs that it represents are also increasing, and the availability of the storage hardware is not able to follow…

Image and Video Processing · Electrical Eng. & Systems 2022-03-21 Xavier Pic , Marc Antonini

Synchronization errors, such as insertions and deletions, present a fundamental challenge in DNA-based data storage systems, arising from both synthesis and sequencing noise. These channels are often modeled as…

Information Theory · Computer Science 2025-06-23 Ziv Aharoni , Henry D. Pfister
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