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Machine learning analysis of neuroimaging data can accurately predict chronological age in healthy people and deviations from healthy brain ageing have been associated with cognitive impairment and disease. Here we sought to further…

Brain age is the estimate of biological age derived from neuroimaging datasets using machine learning algorithms. Increasing brain age with respect to chronological age can reflect increased vulnerability to neurodegeneration and cognitive…

Quantitative Methods · Quantitative Biology 2024-02-13 Saurabh Sihag , Gonzalo Mateos , Alejandro Ribeiro

Neuroimaging-driven prediction of brain age, defined as the predicted biological age of a subject using only brain imaging data, is an exciting avenue of research. In this work we seek to build models of brain age based on functional…

Understanding human fetal neurodevelopment is of great clinical importance as abnormal development is linked to adverse neuropsychiatric outcomes after birth. Recent advances in functional Magnetic Resonance Imaging (fMRI) have provided new…

Image and Video Processing · Electrical Eng. & Systems 2019-06-11 Xiangrui Li , Jasmine Hect , Moriah Thomason , Dongxiao Zhu

Brain age estimation from Magnetic Resonance Images (MRI) derives the difference between a subject's biological brain age and their chronological age. This is a potential biomarker for neurodegeneration, e.g. as part of Alzheimer's disease.…

Computer Vision and Pattern Recognition · Computer Science 2020-10-02 Kyriaki-Margarita Bintsi , Vasileios Baltatzis , Arinbjörn Kolbeinsson , Alexander Hammers , Daniel Rueckert

In this work, deep learning techniques for brain age prediction from magnetic resonance images are investigated, aiming to assist in the identification of biomarkers of the natural aging process. The identification of biomarkers is useful…

Image and Video Processing · Electrical Eng. & Systems 2021-12-24 Victor H. R. Oliveira , Augusto Antunes , Alexandre S. Soares , Arthur D. Reys , Robson Z. Júnior , Saulo D. S. Pedro , Danilo Silva

Predicting cognition from neuroimaging data in healthy individuals offers insights into the neural mechanisms underlying cognitive abilities, with potential applications in precision medicine and early detection of neurological and…

Machine Learning · Computer Science 2025-07-29 Jagruti Patel , Mikkel Schöttner , Thomas A. W. Bolton , Patric Hagmann

Numerous studies have established that estimated brain age, as derived from statistical models trained on healthy populations, constitutes a valuable biomarker that is predictive of cognitive decline and various neurological diseases. In…

Computer Vision and Pattern Recognition · Computer Science 2019-07-02 Xinyang Feng , Zachary C. Lipton , Jie Yang , Scott A. Small , Frank A. Provenzano

Over the years, Machine Learning models have been successfully employed on neuroimaging data for accurately predicting brain age. Deviations from the healthy brain aging pattern are associated to the accelerated brain aging and brain…

Image and Video Processing · Electrical Eng. & Systems 2023-06-23 M. Tanveer , M. A. Ganaie , Iman Beheshti , Tripti Goel , Nehal Ahmad , Kuan-Ting Lai , Kaizhu Huang , Yu-Dong Zhang , Javier Del Ser , Chin-Teng Lin

Brain aging is a complex and dynamic process, leading to functional and structural changes in the brain. These changes could lead to the increased risk of neurodegenerative diseases and cognitive decline. Accurate brain-age estimation…

Image and Video Processing · Electrical Eng. & Systems 2024-12-30 Saadat Behzadi , Danial Sharifrazi , Roohallah Alizadehsani , Mojtaba Lotfaliany , Mohammadreza Mohebbi

Brain gender differences have been known for a long time and are the possible reason for many psychological, psychiatric and behavioral differences between males and females. Predicting genders from brain functional connectivity (FC) can…

Image and Video Processing · Electrical Eng. & Systems 2020-05-19 Gengyan Zhao , Gyujoon Hwang , Cole J. Cook , Fang Liu , Mary E. Meyerand , Rasmus M. Birn

This study investigated age-related changes in functional connectivity using resting-state fMRI and explored the efficacy of traditional deep learning for classifying brain developmental stages (BDS). Functional connectivity was assessed…

Neurons and Cognition · Quantitative Biology 2025-03-28 Prerna Singh , Kuldeep Singh Yadav , Lalan Kumar , Tapan Kumar Gandhi

Predicting behavioral variables from neuroimaging modalities such as magnetic resonance imaging (MRI) has the potential to allow the development of neuroimaging biomarkers of mental and neurological disorders. A crucial processing step to…

Neurons and Cognition · Quantitative Biology 2025-07-29 Mikkel Schöttner Sieler , Thomas A. W. Bolton , Jagruti Patel , Patric Hagmann

Deep neural networks (DNN) have been designed to predict the chronological age of a healthy brain from T1-weighted magnetic resonance images (T1 MRIs), and the predicted brain age could serve as a valuable biomarker for the early detection…

Image and Video Processing · Electrical Eng. & Systems 2023-05-31 Yu Fu , Yanyan Huang , Shunjie Dong , Yalin Wang , Tianbai Yu , Meng Niu , Cheng Zhuo

Resting-state functional magnetic resonance imaging (rsfMRI) is a powerful tool for investigating the relationship between brain function and cognitive processes as it allows for the functional organization of the brain to be captured…

Machine Learning · Computer Science 2025-02-25 Bishal Thapaliya , Esra Akbas , Jiayu Chen , Raam Sapkota , Bhaskar Ray , Pranav Suresh , Vince Calhoun , Jingyu Liu

Neuroimaging-based prediction methods for intelligence and cognitive abilities have seen a rapid development in literature. Among different neuroimaging modalities, prediction based on functional connectivity (FC) has shown great promise.…

Neurons and Cognition · Quantitative Biology 2023-07-20 Yang Li , Xin Ma , Raj Sunderraman , Shihao Ji , Suprateek Kundu

A novel unsupervised deep learning method is developed to identify individual-specific large scale brain functional networks (FNs) from resting-state fMRI (rsfMRI) in an end-to-end learning fashion. Our method leverages deep Encoder-Decoder…

Computer Vision and Pattern Recognition · Computer Science 2020-12-14 Hongming Li , Yong Fan

Estimated brain age from magnetic resonance image (MRI) and its deviation from chronological age can provide early insights into potential neurodegenerative diseases, supporting early detection and implementation of prevention strategies.…

The deviation between chronological age and biological age is a well-recognized biomarker associated with cognitive decline and neurodegeneration. Age-related and pathology-driven changes to brain structure are captured by various…

Machine Learning · Computer Science 2022-11-01 Saurabh Sihag , Gonzalo Mateos , Corey McMillan , Alejandro Ribeiro
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