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A model's interpretability is essential to many practical applications such as clinical decision support systems. In this paper, a novel interpretable machine learning method is presented, which can model the relationship between input…

Machine Learning · Computer Science 2022-12-06 Heming Yao , Harm Derksen , Jessica R. Golbus , Justin Zhang , Keith D. Aaronson , Jonathan Gryak , Kayvan Najarian

Models obtained by decision tree induction techniques excel in being interpretable.However, they can be prone to overfitting, which results in a low predictive performance. Ensemble techniques are able to achieve a higher accuracy. However,…

Machine Learning · Statistics 2016-11-18 Gilles Vandewiele , Olivier Janssens , Femke Ongenae , Filip De Turck , Sofie Van Hoecke

Manifold learning techniques play a pivotal role in machine learning by revealing lower-dimensional embeddings within high-dimensional data, thus enhancing both the efficiency and interpretability of data analysis by transforming the data…

Neural and Evolutionary Computing · Computer Science 2025-05-02 Ben Cravens , Andrew Lensen , Paula Maddigan , Bing Xue

It is becoming increasingly important for machine learning methods to make predictions that are interpretable as well as accurate. In many practical applications, it is of interest which features and feature interactions are relevant to the…

Machine Learning · Statistics 2016-02-09 Viktoriya Krakovna , Jiong Du , Jun S. Liu

A structural optimization scheme for a single-layer nonnegative adaptive tensor tree (NATT) that models a target probability distribution is proposed as an alternative paradigm for generative modeling. The NATT scheme, by construction,…

Machine Learning · Computer Science 2025-07-02 Katsuya O. Akamatsu , Kenji Harada , Tsuyoshi Okubo , Naoki Kawashima

Responsible for many complex human diseases including cancers, disrupted or abnormal gene interactions can be identified through their expression changes correlating with the progression of a disease. However, the examination of all…

Quantitative Methods · Quantitative Biology 2013-02-18 Salim Chowdhury , Yanjun Qi , Alex Stewart , Rachel Ostroff , Renqiang Min

To understand how deep neural networks perform classification predictions, recent research attention has been focusing on developing techniques to offer desirable explanations. However, most existing methods cannot be easily applied for…

Computer Vision and Pattern Recognition · Computer Science 2023-02-21 Yuan-Chia Cheng , Zu-Yun Shiau , Fu-En Yang , Yu-Chiang Frank Wang

Molecular-level understanding of the interactions between the constituents of an atomic structure is essential for designing novel materials in various applications. This need goes beyond the basic knowledge of the number and types of…

In this paper, to unveil interpretable development-specific gene signatures in human PFC, we propose a novel gene selection method, named Interpretable Causality Gene Selection (ICGS), which adopts a Bayesian Network (BN) to represent…

Neurons and Cognition · Quantitative Biology 2022-11-18 Meng Huang , Xiucai Ye , Tetsuya Sakurai

We consider the analysis of high dimensional data given in the form of a matrix with columns consisting of observations and rows consisting of features. Often the data is such that the observations do not reside on a regular grid, and the…

Machine Learning · Statistics 2017-08-22 Gal Mishne , Ronen Talmon , Israel Cohen , Ronald R. Coifman , Yuval Kluger

Deep learning methods, in particular convolutional neural networks, have emerged as a powerful tool in medical image computing tasks. While these complex models provide excellent performance, their black-box nature may hinder real-world…

Image and Video Processing · Electrical Eng. & Systems 2022-10-18 Yuzhe Lu , Adam Perer

Distinguishing the rare "driver" mutations that fuel cancer progression from the vast background of "passenger" mutations in the non-coding genome is a fundamental challenge in cancer biology. A primary mechanism that non-coding driver…

Genomics · Quantitative Biology 2025-10-01 David Laub , Ethan Armand , Arda Pekis , Zekai Chen , Irsyad Adam , Shaun Porwal , Bing Ren , Kevin Brown , Hannah Carter

Mapper, a topological algorithm, is frequently used as an exploratory tool to build a graphical representation of data. This representation can help to gain a better understanding of the intrinsic shape of high-dimensional genomic data and…

Genomics · Quantitative Biology 2023-07-19 Erik J. Amézquita , Farzana Nasrin , Kathleen M. Storey , Masato Yoshizawa

Graphs are a powerful tool for representing and analyzing unstructured, non-Euclidean data ubiquitous in the healthcare domain. Two prominent examples are molecule property prediction and brain connectome analysis. Importantly, recent works…

Machine Learning · Computer Science 2022-04-04 Kamilia Mullakaeva , Luca Cosmo , Anees Kazi , Seyed-Ahmad Ahmadi , Nassir Navab , Michael M. Bronstein

Developing inherently interpretable models for prediction has gained prominence in recent years. A subclass of these models, wherein the interpretable network relies on learning high-level concepts, are valued because of closeness of…

Computer Vision and Pattern Recognition · Computer Science 2025-03-20 Jayneel Parekh , Quentin Bouniot , Pavlo Mozharovskyi , Alasdair Newson , Florence d'Alché-Buc

Gradual argumentation frameworks represent arguments and their relationships in a weighted graph. Their graphical structure and intuitive semantics makes them a potentially interesting tool for interpretable machine learning. It has been…

Machine Learning · Computer Science 2021-06-28 Jonathan Spieler , Nico Potyka , Steffen Staab

The proliferation of high-dimensional datasets in fields such as genomics, healthcare, and finance has created an urgent need for machine learning models that are both highly accurate and inherently interpretable. While traditional deep…

Machine Learning · Computer Science 2025-10-28 Rekha R Nair , Tina Babu , Alavikunhu Panthakkan , Hussain Al-Ahmad , Balamurugan Balusamy

Graph neural networks (GNNs) are powerful tools on graph data. However, their predictions are mis-calibrated and lack interpretability, limiting their adoption in critical applications. To address this issue, we propose a new…

Machine Learning · Computer Science 2025-08-26 Lingkai Kong , Haotian Sun , Yuchen Zhuang , Haorui Wang , Wenhao Mu , Chao Zhang

Medical imaging diagnosis increasingly relies on Machine Learning (ML) models. This is a task that is often hampered by severely imbalanced datasets, where positive cases can be quite rare. Their use is further compromised by their limited…

Machine Learning · Computer Science 2024-01-26 Yumnah Hasan , Allan de Lima , Fatemeh Amerehi , Darian Reyes Fernandez de Bulnes , Patrick Healy , Conor Ryan

Robots learn reward functions from user demonstrations, but these rewards often fail to generalize to new environments. This failure occurs because learned rewards latch onto spurious correlations in training data rather than the underlying…

Robotics · Computer Science 2026-03-25 Fin Amin , Nathaniel Dennler , Andreea Bobu
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