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High-Q optical resonators allow label-free detection of individual nanoparticles through perturbation of optical signatures but have practical limitations due to reliance on random diffusion to deliver particles to the sensing region. We…

Optics · Physics 2016-10-03 Jeewon Suh , Kewen Han , Christopher W Peterson , Gaurav Bahl

Micro and nanoscale particles are crucial in various fields, from biomedical imaging to environmental processes. While conventional spectroscopy and microscopy methods for characterizing these particles often involve bulky equipment and…

Biological Physics · Physics 2024-11-26 Jie Liao , Maxwell Adolphson , Hangyue Li , Dipayon Kumar Sikder , Chenyang Lu , Lan Yang

The recent development of opto-mechano-fluidic resonators has provided -- by harnessing photon radiation pressure -- a new microfluidics platform for the optical sensing of fluid density and bulk modulus. Here we show that fluid viscosity…

Optics · Physics 2014-07-15 Kewen Han , Kaiyuan Zhu , Gaurav Bahl

Cavity optomechanics provides high-performance sensor technology, and the scheme is also applicable to liquid samples for biological and rheological applications. However, previously reported methods using fluidic capillary channels and…

Optics · Physics 2023-02-06 Motoki Asano , Hiroshi Yamaguchi , Hajime Okamoto

We demonstrate multimode optomechanical sensing of individual nanoparticles with radius of a hundred of nanometers. A semiconductor optomechanical disk resonator is optically driven and detected under ambient conditions, as nebulized…

Optical detection of individual nanometer-sized analytes, virus particles, and protein molecules holds great promise for understanding and control of biological samples and healthcare applications. As fluorescent labels impose restrictions…

Optics · Physics 2020-10-19 Martin Dieter Baaske , Peter Sebastian Neu , Michel Orrit

Droplet microfluidics offers a versatile platform for analyzing liquid samples. Despite its potential, there is a lack of techniques that allow to reliably probe individual circulating droplets. The prospect of combining droplet…

Quantitative Methods · Quantitative Biology 2024-03-08 Marc Sulliger , Jaime Ortega Arroyo , Romain Quidant

The ability to detect and identify molecules at high sensitivity without the use of labels or capture agents is important for medical diagnostics, threat identification, environmental monitoring, and basic science. Microtoroid optical…

Optics · Physics 2022-10-17 Gwangho Choi , Adley Gin , Judith Su

Cavity-enhanced radiation-pressure coupling of optical and mechanical degrees of freedom gives rise to a range of optomechanical phenomena, in particular providing a route to the quantum regime of mesoscopic mechanical oscillators. A prime…

Quantum Physics · Physics 2008-07-18 G. Anetsberger , R. Rivière , A. Schliesser , O. Arcizet , T. J. Kippenberg

Vibrating nano- and micromechanical resonators have been the subject of research aiming at ultrasensitive mass sensors for mass spectrometry, chemical analysis and biomedical diagnosis. Unfortunately, their merits diminish dramatically in…

Instrumentation and Detectors · Physics 2015-09-30 E. Gil-Santos , C. Baker , D. T. Nguyen , W. Hease , A. Lemaître , S. Ducci , G. Leo , I. Favero

Opto-mechano-fluidic resonators (OMFRs) are a new platform for high-throughput sensing of the mechanical properties of freely flowing microparticles in arbitrary media. Experimental extraction of OMFR mode shapes, especially the acoustic…

Optics · Physics 2018-03-14 Jeewon Suh , Kewen Han , Gaurav Bahl

Currently, optical- or mechanical-resonances are commonly used in microfluidic research. However, optomechanical oscillations by light pressure were not shown with liquids. This is because replacing the surrounding air with water inherently…

Many optical measurement techniques, such as light scattering from wavelength-scale particles or detecting motion from a surface with an optical lever, encode information in a complex radiation pattern. Extracting all available information…

Quantum Physics · Physics 2025-12-22 Youssef Tawfik , Shan Hao , Thomas P. Purdy

Label-free detecting multiple analytes in a high-throughput fashion has been one of the long-sought goals in biosensing applications. Yet, for all-optical approaches, interfacing state-of-the-art label-free techniques with microfluidics…

Quantitative Methods · Quantitative Biology 2023-08-14 Alexia Stollmann , Jose Garcia-Guirado , Jae-Sang Hong , Hyungsoon Im , Hakho Lee , Jaime Ortega Arroyo , Romain Quidant

Microbubbles - used as contrast agents in ultrasound imaging - are important tools in biomedical research, having been used together with ultrasound to develop significant diagnostic and therapeutic techniques. It has been suggested that…

Medical Physics · Physics 2022-11-23 Prashant Pandey

Precision measurement of non-linear observables is an important goal in all facets of quantum optics. This allows measurement-based non-classical state preparation, which has been applied to great success in various physical systems, and…

Quantum Physics · Physics 2017-10-20 G. A. Brawley , M. R. Vanner , P. E. Larsen , S. Schmid , A. Boisen , W. P. Bowen

Detecting and weighing the individual nanoparticles is an important approach to study the behavior and properties of single particles. Here we illustrate an effective mass sensing scheme using optomechanical resonator system. Based on the…

Quantum Physics · Physics 2016-07-28 Yong-Pan Gao , Tie-Jun Wang , Cong Cao , Si-Chen Mi , Daquan Yang , Yong Zhang , Chuan Wang

The interaction-free measurement is a fundamental quantum effect whereby the presence of a photosensitive object is determined without irreversible photon absorption. Here we propose the concept of coherent interaction-free detection and…

Quantum Physics · Physics 2023-07-10 Shruti Dogra , John J. McCord , Gheorghe Sorin Paraoanu

Exposure to bio-aerosols such as mold spores and pollen can lead to adverse health effects. There is a need for a portable and cost-effective device for long-term monitoring and quantification of various bio-aerosols. To address this need,…

Applied Physics · Physics 2022-11-23 Yi Luo , Yijie Zhang , Tairan Liu , Alan Yu , Yichen Wu , Aydogan Ozcan

Many essential cellular functions depend on the viscoelastic properties of the cytoplasm. While techniques such as optical tweezers and atomic force microscopy can measure these properties, their reliance on localized probes prevents…

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