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G-computation has become a widely used robust method for estimating unconditional (marginal) treatment effects with covariate adjustment in the analysis of randomized clinical trials. Statistical inference in this context typically relies…

Methodology · Statistics 2025-03-18 Xin Zhang , Haitao Chu , Lin Liu , Satrajit Roychoudhury

The literature in social network analysis has largely focused on methods and models which require complete network data; however there exist many networks which can only be studied via sampling methods due to the scale or complexity of the…

Applications · Statistics 2019-11-25 Haema Nilakanta , Zack W. Almquist , Galin L. Jones

Bayesian modelling and computational inference by Markov chain Monte Carlo (MCMC) is a principled framework for large-scale uncertainty quantification, though is limited in practice by computational cost when implemented in the simplest…

Computation · Statistics 2020-09-21 Colin Fox , Tiangang Cui , Markus Neumayer

Testing the association between a phenotype and many genetic variants from case-control data is essential in genome-wide association study (GWAS). This is a challenging task as many such variants are correlated or non-informative.…

Methodology · Statistics 2016-01-25 Zhendong Huang , Davide Ferrari , Guoqi Qian

The problem of computing posterior functionals in general high-dimensional statistical models with possibly non-log-concave likelihood functions is considered. Based on the proof strategy of Nickl and Wang (2022), but using only local…

Statistics Theory · Mathematics 2025-07-24 Randolf Altmeyer

Bayesian inference with Markov Chain Monte Carlo (MCMC) is challenging when the likelihood function is irregular and expensive to compute. We explore several sampling algorithms that make use of subset evaluations to reduce computational…

Machine Learning · Statistics 2025-05-16 Conor Rosato , Harvinder Lehal , Simon Maskell , Lee Devlin , Malcolm Strens

The Mann-Kendall test for trend has gained a lot of attention in a range of disciplines, especially in the environmental sciences. One of the drawbacks of the Mann-Kendall test when applied to real data is that no distinction can be made…

Methodology · Statistics 2023-05-24 Stavros Nikolakopoulos , Eric Cator , Mart P. Janssen

The recently introduced framework of universal inference provides a new approach to constructing hypothesis tests and confidence regions that are valid in finite samples and do not rely on any specific regularity assumptions on the…

Statistics Theory · Mathematics 2023-09-11 David Strieder , Mathias Drton

Markov chain Monte Carlo (MCMC) methods asymptotically sample from complex probability distributions. The pseudo-marginal MCMC framework only requires an unbiased estimator of the unnormalized probability distribution function to construct…

Computation · Statistics 2016-05-25 Iain Murray , Matthew M. Graham

A general and relatively simple method for construction of multivariate goodness-of-fit tests is introduced. The proposed test is applied to elliptical distributions. The method is based on a characterization of probability distributions…

Methodology · Statistics 2022-06-22 Feifei Chen , M. Dolores Jiménez-Gamero , Simos Meintanis , Lixing Zhu

Particle physics experiments use likelihood ratio tests extensively to compare hypotheses and to construct confidence intervals. Often, the null distribution of the likelihood ratio test statistic is approximated by a $\chi^2$ distribution,…

Data Analysis, Statistics and Probability · Physics 2022-04-06 Sara Algeri , Jelle Aalbers , Knut Dundas Morå , Jan Conrad

Can we make Bayesian posterior MCMC sampling more efficient when faced with very large datasets? We argue that computing the likelihood for N datapoints in the Metropolis-Hastings (MH) test to reach a single binary decision is…

Machine Learning · Computer Science 2014-02-17 Anoop Korattikara , Yutian Chen , Max Welling

The widespread use of Markov Chain Monte Carlo (MCMC) methods for high-dimensional applications has motivated research into the scalability of these algorithms with respect to the dimension of the problem. Despite this, numerous problems…

Computation · Statistics 2024-10-21 Ardjen Pengel , Jun Yang , Zhou Zhou

We consider the outstanding problem of sampling from an unnormalized density that may be non-log-concave and multimodal. To enhance the performance of simple Markov chain Monte Carlo (MCMC) methods, techniques of annealing type have been…

Machine Learning · Statistics 2025-02-18 Wei Guo , Molei Tao , Yongxin Chen

We propose several statistics to test the Markov hypothesis for $\beta$-mixing stationary processes sampled at discrete time intervals. Our tests are based on the Chapman--Kolmogorov equation. We establish the asymptotic null distributions…

Statistics Theory · Mathematics 2016-08-14 Yacine Aït-Sahalia , Jianqing Fan , Jiancheng Jiang

Pearson's chi-squared test, from 1900, is the standard statistical tool for "hypothesis testing on distributions": namely, given samples from an unknown distribution $Q$ that may or may not equal a hypothesis distribution $P$, we want to…

Statistics Theory · Mathematics 2023-10-17 Trung Dang , Walter McKelvie , Paul Valiant , Hongao Wang

We explain the fundamental challenges of sampling from multimodal distributions, particularly for high-dimensional problems. We present the major types of MCMC algorithms that are designed for this purpose, including parallel tempering,…

Computation · Statistics 2025-01-13 Krzysztof Łatuszyński , Matthew T. Moores , Timothée Stumpf-Fétizon

Existing two-sample testing techniques, particularly those based on choosing a kernel for the Maximum Mean Discrepancy (MMD), often assume equal sample sizes from the two distributions. Applying these methods in practice can require…

Machine Learning · Statistics 2025-12-17 Aaron Wei , Milad Jalali , Danica J. Sutherland

A Cramer moderate deviation theorem for Hotelling's $T^2$-statistic is proved under a finite $(3+\delta)$th moment. The result is applied to large scale tests on the equality of mean vectors and is shown that the number of tests can be as…

Statistics Theory · Mathematics 2013-04-09 Weidong Liu , Qi-Man Shao

While the Matrix Generalized Inverse Gaussian ($\mathcal{MGIG}$) distribution arises naturally in some settings as a distribution over symmetric positive semi-definite matrices, certain key properties of the distribution and effective ways…

Machine Learning · Statistics 2016-08-23 Farideh Fazayeli , Arindam Banerjee