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Low-dose computed tomography (CT) plays a significant role in reducing the radiation risk in clinical applications. However, lowering the radiation dose will significantly degrade the image quality. With the rapid development and wide…
Optical coherence tomography (OCT) is a high-resolution three-dimensional imaging technique that enables non-destructive measurements of surface and subsurface microstructures. Recent developments of OCT operating in the mid-infrared (MIR)…
Optical coherence tomography (OCT) is a non-invasive imaging technique that can produce images of the eye at the microscopic level. OCT image segmentation to localise retinal layer boundaries is a fundamental procedure for diagnosing and…
Light scattering imposes a major obstacle for imaging objects seated deeply in turbid media, such as biological tissues and foggy air. Diffuse optical tomography (DOT) tackles scattering by volumetrically recovering the optical absorbance…
Optical Coherence Tomography (OCT) is a novel and effective screening tool for ophthalmic examination. Since collecting OCT images is relatively more expensive than fundus photographs, existing methods use multi-modal learning to complement…
Accurately segmenting fluid in 3D optical coherence tomography (OCT) images is critical for detecting eye diseases but remains challenging. Traditional autoencoder-based methods struggle with resolution loss and information recovery. While…
Many naturally-occuring models in the sciences are well-approximated by simplified models, using multiscale techniques. In such settings it is natural to ask about the relationship between inverse problems defined by the original problem…
Optical coherence tomography angiography (OCTA) is a non-invasive imaging modality that extends the functionality of OCT by extracting moving red blood cell signals from surrounding static biological tissues. OCTA has emerged as a valuable…
Out-of-distribution (OOD) detection is essential to improve the reliability of machine learning models by detecting samples that do not belong to the training distribution. Detecting OOD samples effectively in certain tasks can pose a…
Optical coherence tomography (OCT) can perform non-invasive high-resolution three-dimensional (3D) imaging and has been widely used in biomedical fields, while it is inevitably affected by coherence speckle noise which degrades OCT imaging…
Optical Doppler Tomography (ODT) is an emerging blood flow analysis technique. A 2D ODT image (B-scan) is generated by sequentially acquiring 1D depth-resolved raw A-scans (A-line) along the lateral axis (B-line), followed by Doppler…
This dissertation relates to the transition of the state of the art of swept source optical coherence tomography (SS-OCT) systems to a new realm in which the image acquisition speed is improved by an order of magnitude. With the aid of a…
Medical imaging is nowadays a pillar in diagnostics and therapeutic follow-up. Current research tries to integrate established - but ionizing - tomographic techniques with technologies offering reduced radiation exposure. Diffuse Optical…
In this paper, we report on the development progress of correlation-based optical time domain reflectometry (OTDR). Substituting the direct detection receiver with a coherent receiver enables to extract the phase and polarization…
Diffraction tomography (DT) has been widely explored in transmission-mode configurations, enabling high-resolution, label-free 3D imaging. However, industrial metrology applications, such as semiconductor inspection, typically involve…
Speckle is an intrinsic pattern in optical coherence tomography (OCT) that obscures fine image features and degrades effective resolution. In this study, we propose a numerical speckle reduction method based on the dispersed scatterer model…
We demonstrate in vivo endoscopic optical coherence tomography (OCT) imaging in the forward direction using a flexible fiber bundle. In comparison to current conventional forward looking probe schemes, our approach simplifies the endoscope…
Computational corrections of defocus and aberrations in optical coherence tomography (OCT) offers a promising approach to realize high-resolution imaging with deep imaging depth, but without additional high hardware costs. However, these…
Optical Coherence Tomography (OCT) has become an indispensable tool for investigating mesoscopic features in soft matter and fluid mechanics. Its ability to provide high-resolution, non-invasive measurements in both spatial and temporal…
A unified method for three-dimensional reconstruction of objects from transmission images collected at multiple illumination directions is described. The method may be applicable to experimental conditions relevant to absorption-based,…