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Histology has long been a foundational technique for studying anatomical structures through tissue slicing. Advances in computational methods now enable three dimensional (3D) reconstruction of organs from histology images, enhancing the…

Quantitative Methods · Quantitative Biology 2025-03-05 Alessandro Ascani Orsini , Manan Bhatt , Pierce L. Perkins , Siyu Wang , Kiara N. Quinn , Kenzi Griffith , Fausto Kang , Nitish V. Thakor

Numerical simulations rely on constructing accurate and detailed models to produce reliable results - a task that is often challenging. This task becomes notably more difficult when the model is of the human brain. We create an anatomically…

Computational Engineering, Finance, and Science · Computer Science 2024-10-11 Andy Huynh , Benjamin Zwick , Mostafa Jamshidian , Michael Halle , Adam Wittek , Karol Miller

Surgical resection is a common procedure in the treatment of pediatric posterior fossa tumors. However, surgical damage is often unavoidable and its association with postoperative complications is not well understood. A reliable…

Image and Video Processing · Electrical Eng. & Systems 2022-03-07 Silu Zhang , Stuart McAfee , Zoltan Patay , Matthew Scoggins

Registration of pre-operative and post-recurrence brain images is often needed to evaluate the effectiveness of brain gliomas treatment. While recent deep learning-based deformable registration methods have achieved remarkable success with…

Image and Video Processing · Electrical Eng. & Systems 2022-06-09 Tony C. W. Mok , Albert C. S. Chung

Developing automated and semi-automated solutions for reconstructing wiring diagrams of the brain from electron micrographs is important for advancing the field of connectomics. While the ultimate goal is to generate a graph of neuron…

Computer Vision and Pattern Recognition · Computer Science 2016-08-09 William Gray Roncal , Colin Lea , Akira Baruah , Gregory D. Hager

Brain extraction or whole brain segmentation is an important first step in many of the neuroimage analysis pipelines. The accuracy and robustness of brain extraction, therefore, is crucial for the accuracy of the entire brain analysis…

Computer Vision and Pattern Recognition · Computer Science 2017-06-21 Seyed Sadegh Mohseni Salehi , Deniz Erdogmus , Ali Gholipour

MR images of fetuses allow clinicians to detect brain abnormalities in an early stage of development. The cornerstone of volumetric and morphologic analysis in fetal MRI is segmentation of the fetal brain into different tissue classes.…

Image and Video Processing · Electrical Eng. & Systems 2019-06-12 N. Khalili , N. Lessmann , E. Turk , N. Claessens , R. de Heus , T. Kolk , M. A. Viergever , M. J. N. L. Benders , I. Isgum

We present 2 statistical models of the skull and mandible built upon an elastic registration method of 3D meshes. The aim of this work is to relate degrees of freedom of skull anatomy, as static relations are of main interest for…

Medical Physics · Physics 2016-08-16 Maxime Berar , Michel Desvignes , Gérard Bailly , Yohan Payan

Three-dimensional (3D) reconstruction of head Computed Tomography (CT) images elucidates the intricate spatial relationships of tissue structures, thereby assisting in accurate diagnosis. Nonetheless, securing an optimal head CT scan…

Computer Vision and Pattern Recognition · Computer Science 2023-09-18 Bowen Zheng , Chenxi Huang , Yuemei Luo

Human brain atlases provide spatial reference systems for data characterizing brain organization at different levels, coming from different brains. Cytoarchitecture is a basic principle of the microstructural organization of the brain, as…

Image and Video Processing · Electrical Eng. & Systems 2021-07-07 Christian Schiffer , Hannah Spitzer , Kai Kiwitz , Nina Unger , Konrad Wagstyl , Alan C. Evans , Stefan Harmeling , Katrin Amunts , Timo Dickscheid

The three-dimensional data-driven Allen Gene Expression Atlas of the adult mouse brain consists of numerized in-situ hybridization data for thousands of genes, co-registered to the Allen Reference Atlas. We propose quantitative criteria to…

Quantitative Methods · Quantitative Biology 2012-05-15 Pascal Grange , Partha P. Mitra

Computed tomography imaging is well accepted for its imaging speed, image contrast & resolution and cost. Thus it has wide use in detection and diagnosis of brain diseases. But unfortunately reported works on CT segmentation is not very…

Computer Vision and Pattern Recognition · Computer Science 2018-10-23 Soumi Ray , Vinod Kumar , Chirag Ahuja , Niranjan Khandelwal

Reconstructing multiple molecularly defined neurons from individual brains and across multiple brain regions can reveal organizational principles of the nervous system. However, high resolution imaging of the whole brain is a technically…

Computer Vision and Pattern Recognition · Computer Science 2019-03-19 James Gornet , Kannan Umadevi Venkataraju , Arun Narasimhan , Nicholas Turner , Kisuk Lee , H. Sebastian Seung , Pavel Osten , Uygar Sümbül

Accurate registration of brain MRI scans is fundamental for cross-subject analysis in neuroscientific studies. This involves aligning both the cortical surface of the brain and the interior volume. Traditional methods treat volumetric and…

Computer Vision and Pattern Recognition · Computer Science 2025-12-24 S. Mazdak Abulnaga , Andrew Hoopes , Malte Hoffmann , Robin Magnet , Maks Ovsjanikov , Lilla Zöllei , John Guttag , Bruce Fischl , Adrian Dalca

A computational anatomy atlas is a set of internal organ geometries. It is based on data of real patients and complemented with virtual cases by using a some numerical approach. Atlases are in demand in computational physiology, especially…

Tissues and Organs · Quantitative Biology 2023-03-21 Konstantin Ushenin , Maksim Dzhigil , Vladislav Dordiuk

The automatic segmentation of perinatal brain structures in magnetic resonance imaging (MRI) is of utmost importance for the study of brain growth and related complications. While different methods exist for adult and pediatric MRI data,…

Magnetic resonance imaging (MRI) is the standard modality to understand human brain structure and function in vivo (antemortem). Decades of research in human neuroimaging has led to the widespread development of methods and tools to provide…

Synchrotron radiation-based X-ray microtomography is uniquely suited for post mortem three-dimensional visualization of organs such as the mouse brain. Tomographic imaging of the entire mouse brain with isotropic cellular resolution…

Automated segmentation of brain tumors from 3D magnetic resonance images (MRIs) is necessary for the diagnosis, monitoring, and treatment planning of the disease. Manual delineation practices require anatomical knowledge, are expensive,…

Computer Vision and Pattern Recognition · Computer Science 2018-11-20 Andriy Myronenko

Segmentation of brain structures in a large dataset of magnetic resonance images (MRI) necessitates automatic segmentation instead of manual tracing. Automatic segmentation methods provide a much-needed alternative to manual segmentation…

Image and Video Processing · Electrical Eng. & Systems 2020-08-11 Mohammad-Parsa Hosseini , Esmaeil Davoodi , Evangelia Bouzos , Kost Elisevich , Hamid Soltanian-Zadeh