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In biomedical research, repeated measurements within each subject are often processed to remove artifacts and unwanted sources of variation. The resulting data are used to construct derived outcomes that act as proxies for scientific…

Methodology · Statistics 2026-02-03 Zihang Wang , Razieh Nabi , Benjamin B. Risk

Effective and reliable evaluation is essential for advancing empirical machine learning. However, the increasing accessibility of generalist models and the progress towards ever more complex, high-level tasks make systematic evaluation more…

Machine Learning · Computer Science 2025-02-10 Felix Leeb , Zhijing Jin , Bernhard Schölkopf

We present a precise definition of cause and effect in terms of a fundamental notion called unresponsiveness. Our definition is based on Savage's (1954) formulation of decision theory and departs from the traditional view of causation in…

Artificial Intelligence · Computer Science 2015-05-19 David Heckerman , Ross D. Shachter

Most machine learning (ML) models are developed for prediction only; offering no option for causal interpretation of their predictions or parameters/properties. This can hamper the health systems' ability to employ ML models in clinical…

Background and Aims: The methods with which prediction models are usually developed mean that neither the parameters nor the predictions should be interpreted causally. However, when prediction models are used to support decision making,…

Methodology · Statistics 2021-01-25 Lijing Lin , Matthew Sperrin , David A. Jenkins , Glen P. Martin , Niels Peek

We present a basis for studying questions of cause and effect in statistics which subsumes and reconciles the models proposed by Pearl, Robins, Rubin and others, and which, as far as mathematical notions and notation are concerned, is…

Statistics Theory · Mathematics 2023-04-18 José A. Ferreira

Recently, there has been great interest in estimating the conditional average treatment effect using flexible machine learning methods. However, in practice, investigators often have working hypotheses about effect heterogeneity across…

Methodology · Statistics 2023-09-13 Chan Park , Hyunseung Kang

Evaluation of counterfactual queries (e.g., "If A were true, would C have been true?") is important to fault diagnosis, planning, determination of liability, and policy analysis. We present a method of revaluating counterfactuals when the…

Artificial Intelligence · Computer Science 2013-02-21 Alexander Balke , Judea Pearl

Causal inference in connected populations is non-trivial, because the treatment assignments of units can affect the outcomes of other units via treatment and outcome spillover. Since outcome spillover induces dependence among outcomes,…

Methodology · Statistics 2025-12-25 Subhankar Bhadra , Michael Schweinberger

When people reason about cause and effect, they often consider many competing "what if" scenarios before deciding which explanation fits best. Analogously, advanced language models capable of causal inference can consider multiple…

Machine Learning · Computer Science 2026-03-10 Finn G. Vamosi , Nils D. Forkert

The study of causality or causal inference - how much a given treatment causally affects a given outcome in a population - goes way beyond correlation or association analysis of variables, and is critical in making sound data driven…

Databases · Computer Science 2017-08-09 Sudeepa Roy , Babak Salimi

We describe the interface between measure theoretic probability and causal inference by constructing causal models on probability spaces within the potential outcomes framework. We find that measure theory provides a precise and instructive…

Statistics Theory · Mathematics 2019-07-04 Irineo Cabreros , John D. Storey

In many applications, there is a need to predict the effect of an intervention on different individuals from data. For example, which customers are persuadable by a product promotion? which patients should be treated with a certain type of…

Machine Learning · Computer Science 2021-03-16 Jiuyong Li , Weijia Zhang , Lin Liu , Kui Yu , Thuc Duy Le , Jixue Liu

We address the problem of integrating data from multiple, possibly biased, observational and interventional studies, to eventually compute counterfactuals in structural causal models. We start from the case of a single observational dataset…

Methodology · Statistics 2023-08-01 Marco Zaffalon , Alessandro Antonucci , Rafael Cabañas , David Huber

One of the fundamental challenges found throughout the data sciences is to explain why things happen in specific ways, or through which mechanisms a certain variable $X$ exerts influences over another variable $Y$. In statistics and machine…

Methodology · Statistics 2023-06-09 Drago Plecko , Elias Bareinboim

In this paper, we propose a novel method for causal inference within the framework of counterfactual and synthetic control. Matching forward the generalized synthetic control method, our instrumented principal component analysis method…

Econometrics · Economics 2024-09-17 Cong Wang

Causal inference on multiple non-independent outcomes raises serious challenges, because multivariate techniques that properly account for the outcome's dependence structure need to be considered. We focus on the case of binary outcomes…

Methodology · Statistics 2018-05-11 Monia Lupparelli , Alessandra Mattei

We present a comprehensive language theoretic causality analysis framework for explaining safety property violations in the setting of concurrent reactive systems. Our framework allows us to uniformly express a number of causality notions…

Formal Languages and Automata Theory · Computer Science 2019-01-04 Rayna Dimitrova , Rupak Majumdar , Vinayak S. Prabhu

Causal inference is capable of estimating the treatment effect (i.e., the causal effect of treatment on the outcome) to benefit the decision making in various domains. One fundamental challenge in this research is that the treatment…

Machine Learning · Computer Science 2021-12-28 Qian Li , Zhichao Wang , Shaowu Liu , Gang Li , Guandong Xu

We show that one can perform causal inference in a natural way for continuous-time scenarios using tools from stochastic analysis. This provides new alternatives to the positivity condition for inverse probability weighting. The probability…

Statistics Theory · Mathematics 2013-04-23 Kjetil Røysland
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