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Retinal neovascularization (RNV) is a vision threatening development in diabetic retinopathy (DR). Vision loss associated with RNV is preventable with timely intervention, making RNV clinical screening and monitoring a priority. Optical…

Image and Video Processing · Electrical Eng. & Systems 2026-04-01 Jinyi Hao , Jie Wang , Liqin Gao , Tristan T. Hormel , Yukun Guo , An-Lun Wu , Christina J. Flaxel , Steven T. Bailey , Kotaro Tsuboi , Thomas S. Hwang , Yali Jia

Optical Coherence Tomography (OCT) is a non-invasive imaging modality essential for diagnosing various eye diseases. Despite its clinical significance, developing OCT-based diagnostic tools faces challenges, such as limited public datasets,…

Computer Vision and Pattern Recognition · Computer Science 2025-01-30 Mohammadreza Saraei , Igor Kozak , Eung-Joo Lee

Optical coherence tomography angiography (OCTA) is a novel non-invasive imaging modality that allows micron-level resolution to visualize the retinal microvasculature. The retinal vessel segmentation in OCTA images is still an open problem,…

Image and Video Processing · Electrical Eng. & Systems 2022-05-10 Mingchao Li , Yerui Chen , Weiwei Zhang , Qiang Chen

Biological tissues are composed of discrete compartments of biochemical media that often exhibit subtle differences in refractive index. Light propagating through these compartments partially diffracts in a forward direction with a pi/2…

Optics · Physics 2025-05-12 Gregory N. McKay , Jerome Mertz , Nicholas J. Durr

Optical coherence tomography (OCT) has revolutionized retinal disease diagnosis with its high-resolution and three-dimensional imaging nature, yet its full diagnostic automation in clinical practices remains constrained by multi-stage…

Automatic segmentation of retina vessels plays a pivotal role in clinical diagnosis of prevalent eye diseases, such as, Diabetic Retinopathy or Age-related Macular Degeneration. Due to the complex construction of blood vessels, with…

Image and Video Processing · Electrical Eng. & Systems 2023-02-21 Benjamin Hou

Modern biomedical image analysis using deep learning often encounters the challenge of limited annotated data. To overcome this issue, deep generative models can be employed to synthesize realistic biomedical images. In this regard, we…

Image and Video Processing · Electrical Eng. & Systems 2026-02-23 Yuli Wu , Weidong He , Dennis Eschweiler , Ningxin Dou , Zixin Fan , Shengli Mi , Peter Walter , Johannes Stegmaier

Laser Doppler holography is a planar blood flow imaging technique recently introduced in ophthalmology to image human retinal and choroidal blood flow non-invasively. Here we present a digital method based on the Doppler spectrum asymmetry…

Medical Physics · Physics 2021-08-10 Léo Puyo , Michel Paques , Michael Atlan

Visible light optical coherence tomography (vis-OCT) is gaining traction for retinal imaging due to its high resolution and functional capabilities. However, the significant absorption of hemoglobin in the visible light range leads to…

Image and Video Processing · Electrical Eng. & Systems 2024-11-14 Razieh Ganjee , Bingjie Wang , Lingyun Wang , Chengcheng Zhao , José-Alain Sahel , Shaohua Pi

Retinopathy of Prematurity (ROP) is an eye disorder primarily affecting premature infants with lower weights. It causes proliferation of vessels in the retina and could result in vision loss and, eventually, retinal detachment, leading to…

Image and Video Processing · Electrical Eng. & Systems 2020-04-06 Alexander Ding , Qilei Chen , Yu Cao , Benyuan Liu

Optical Coherence Tomography (OCT) is an imaging modality that has been widely adopted for visualizing corneal, retinal and limbal tissue structure with micron resolution. It can be used to diagnose pathological conditions of the eye, and…

Image and Video Processing · Electrical Eng. & Systems 2019-05-08 Jiahong Ouyang , Tejas Sudharshan Mathai , Kira Lathrop , John Galeotti

The morphological attributes of retinal vessels, such as length, width, tortuosity and branching pattern and angles, play an important role in diagnosis, screening, treatment, and evaluation of various cardiovascular and ophthalmologic…

Image and Video Processing · Electrical Eng. & Systems 2019-11-25 Zhengyuan Liu

Recent advancements in medical image analysis have led to the development of highly specialized models tailored to specific clinical tasks. These models have demonstrated exceptional performance and remain a crucial research direction. Yet,…

Computer Vision and Pattern Recognition · Computer Science 2025-06-19 Alessio Negrini , Simon Reiß

Optical coherence tomography (OCT) is a noninvasive imaging modality which can be used to obtain depth images of the retina. The changing layer thicknesses can thus be quantified by analyzing these OCT images, moreover these changes have…

Computer Vision and Pattern Recognition · Computer Science 2018-03-15 Yufan He , Aaron Carass , Bruno M. Jedynak , Sharon D. Solomon , Shiv Saidha , Peter A. Calabresi , Jerry L. Prince

Optical Coherence Tomography (OCT) is a novel and effective screening tool for ophthalmic examination. Since collecting OCT images is relatively more expensive than fundus photographs, existing methods use multi-modal learning to complement…

Image and Video Processing · Electrical Eng. & Systems 2023-08-02 Lehan Wang , Weihang Dai , Mei Jin , Chubin Ou , Xiaomeng Li

An accurate and automated tissue segmentation algorithm for retinal optical coherence tomography (OCT) images is crucial for the diagnosis of glaucoma. However, due to the presence of the optic disc, the anatomical structure of the…

Image and Video Processing · Electrical Eng. & Systems 2021-02-10 Jiaxuan Li , Peiyao Jin , Jianfeng Zhu , Haidong Zou , Xun Xu , Min Tang , Minwen Zhou , Yu Gan , Jiangnan He , Yuye Ling , Yikai Su

Optical coherence tomography (OCT) captures cross-sectional data and is used for the screening, monitoring, and treatment planning of retinal diseases. Technological developments to increase the speed of acquisition often results in systems…

Image and Video Processing · Electrical Eng. & Systems 2023-01-03 Timothy T. Yu , Da Ma , Jayden Cole , Myeong Jin Ju , Mirza F. Beg , Marinko V. Sarunic

Alterations in retinal layer thickness, measurable using Optical Coherence Tomography (OCT), have been associated with neurodegenerative diseases such as Alzheimer's disease (AD). While previous studies have mainly focused on segmented…

Computer Vision and Pattern Recognition · Computer Science 2025-11-10 Yasemin Turkan , F. Boray Tek , M. Serdar Nazlı , Öykü Eren

Optical coherence tomography (OCT), a commonly used retinal imaging modality, plays a central role in retinal disease diagnosis by providing high-resolution visualization of retinal layers. While deep learning (DL) has achieved expert-level…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Tienyu Chang , Tianhao Li , Ruogu Fang , Jiang Bian , Yu Huang

The choroid, a highly vascular layer behind the retina, is an extension of the central nervous system and has parallels with the renal cortex, with blood flow far exceeding that of the brain and kidney. Thus, there has been growing interest…

Image and Video Processing · Electrical Eng. & Systems 2025-02-12 Jamie Burke