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In complex systems, feedback loops can build intricate emergent phenomena, so that a description of the whole system cannot be easily derived from the properties of the individual parts. Here we propose that inter-molecular frustration…

Molecular Networks · Quantitative Biology 2011-09-26 Andre M. Lindo , Bruno F. Faria , Fernao V. de Abreu

Fractures are normally present in the underground and are, for some physical processes, of paramount importance. Their accurate description is fundamental to obtain reliable numerical outcomes useful, e.g., for energy management. Depending…

Numerical Analysis · Mathematics 2021-03-03 Alessio Fumagalli , Francesco Saverio Patacchini

A method is presented for calculating solutions to differential equations analytically for a variety of problems in physics. An iteration procedure based on the recently proposed BLUES (Beyond Linear Use of Equation Superposition) function…

Pattern Formation and Solitons · Physics 2020-12-09 Jonas Berx , Joseph O. Indekeu

As in the case of soliton PDEs in 2+1 dimensions, the evolutionary form of integrable dispersionless multidimensional PDEs is non-local, and the proper choice of integration constants should be the one dictated by the associated Inverse…

Exactly Solvable and Integrable Systems · Physics 2018-05-01 P. G. Grinevich , P. M. Santini

At present it is still quite difficult to match the vast knowledge on the behavior of individual tumor cells with macroscopic measurements on clinical tumors. On the modeling side, we already know how to deal with many molecular pathways…

Tissues and Organs · Quantitative Biology 2012-01-16 Roberto Chignola , Edoardo Milotti

Many models of fractal growth patterns (like Diffusion Limited Aggregation and Dielectric Breakdown Models) combine complex geometry with randomness; this double difficulty is a stumbling block to their elucidation. In this paper we…

Statistical Mechanics · Physics 2007-05-23 Benny Davidovich , M. J. Feigenbaum , H. G. E. Hentschel , Itamar Procaccia

Stable computational algorithms for the approximate solution of the Cauchy problem for nonstationary problems are based on implicit time approximations. Computational costs for boundary value problems for systems of coupled multidimensional…

Numerical Analysis · Mathematics 2024-03-28 P. N. Vabishchevich

Personalized cancer treatments based on the molecular profile of a patient's tumor are an emerging and exciting class of treatments in oncology. As genomic tumor profiling is becoming more common, targeted treatments to specific molecular…

In applications throughout science and engineering one is often faced with the challenge of solving an ill-posed inverse problem, where the number of available measurements is smaller than the dimension of the model to be estimated. However…

Optimization and Control · Mathematics 2012-10-30 Venkat Chandrasekaran , Benjamin Recht , Pablo A. Parrilo , Alan S. Willsky

We introduce a new approach to a linear-circular regression problem that relates multiple linear predictors to a circular response. We follow a modeling approach of a wrapped normal distribution that describes angular variables and angular…

Methodology · Statistics 2019-09-17 Ali Esmaieeli Sikaroudi , Chiwoo Park

Contraction analysis establishes exponential incremental convergence of a nonlinear system by solving a linear matrix inequality for a contraction metric, and has become a standard resource for solving problems in nonlinear control and…

Dynamical Systems · Mathematics 2026-03-03 Winfried Lohmiller , Jean-Jacques Slotine

Treatment specific survival curves are an important tool to illustrate the treatment effect in studies with time-to-event outcomes. In non-randomized studies, unadjusted estimates can lead to biased depictions due to confounding. Multiple…

Methodology · Statistics 2023-04-25 Robin Denz , Renate Klaaßen-Mielke , Nina Timmesfeld

Joint space trajectory optimization under end-effector task constraints leads to a challenging non-convex problem. Thus, a real-time adaptation of prior computed trajectories to perturbation in task constraints often becomes intractable.…

Smooth and curved microstructural topologies found in nature - from soap films to trabecular bone - have inspired several mimetic design spaces for architected metamaterials and bio-scaffolds. However, the design approaches so far have been…

Computational Engineering, Finance, and Science · Computer Science 2024-04-17 Yaqi Guo , Saurav Sharma , Siddhant Kumar

Optical diffraction tomography relies on solving an inverse scattering problem governed by the wave equation. Classical reconstruction algorithms are based on linear approximations of the forward model (Born or Rytov), which limits their…

Computational Engineering, Finance, and Science · Computer Science 2017-09-01 Emmanuel Soubies , Thanh-An Pham , Michael Unser

We analyze response of a macromolecule near to a substrate; the substrate is tiled in the sequential and specific manner so that repeat units of the macromolecule may have different response on its adsorption in different directions onto…

Soft Condensed Matter · Physics 2020-09-21 Pramod Kumar Mishra

Mathematical modelling of tumor growth is one of the most useful and inexpensive approaches to determine and predict the stage, size and progression of tumors in realistic geometries. Moreover, these models has been used to get an insight…

Medical Physics · Physics 2017-08-01 Miguel Martín-Landrove

In this work we study the dynamic behaviour of compound shells of revolution partially filled with an ideal incompressible fluid based on boundary-value problems. New analytical mathematical model with corresponding discrete scheme for the…

Computational Engineering, Finance, and Science · Computer Science 2016-06-15 Iryna Kononenko , Oleksiy Kononenko

While topological derivatives have proven useful in applications of topology optimisation and inverse problems, their mathematically rigorous derivation remains an ongoing research topic, in particular in the context of nonlinear partial…

Optimization and Control · Mathematics 2022-07-20 Peter Gangl , Kevin Sturm

The classical Cauchy continuum theory is suitable to model highly homogeneous materials. However, many materials, such as porous media or metamaterials, exhibit a pronounced microstructure. As a result, the classical continuum theory cannot…

Numerical Analysis · Mathematics 2022-08-10 Adam Sky , Michael Neunteufel , Ingo Muench , Joachim Schöberl , Patrizio Neff