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We present a computational motivation for restricted maximum likelihood (REML) estimation in linear mixed models using an expectation--maximization (EM) algorithm. At each iteration, maximum likelihood (ML) and REML solve the same…

Computation · Statistics 2026-02-11 Andrew T. Karl

Debiased machine learning (DML) offers an attractive way to estimate treatment effects in observational settings, where identification of causal parameters requires a conditional independence or unconfoundedness assumption, since it allows…

Econometrics · Economics 2022-06-16 Victor Quintas-Martinez

Event-based models (EBMs) infer disease progression from cross-sectional data, and standard EBMs assume a single underlying disease per individual. In contrast, mixed pathologies are common in neurodegeneration. We introduce the Joint…

Machine Learning · Computer Science 2026-01-14 Hongtao Hao , Joseph L. Austerweil

Retrieval finds a small number of relevant candidates from a large corpus for information retrieval and recommendation applications. A key component of retrieval is to model (user, item) similarity, which is commonly represented as the dot…

Machine Learning · Computer Science 2023-06-08 Jiaqi Zhai , Zhaojie Gong , Yueming Wang , Xiao Sun , Zheng Yan , Fu Li , Xing Liu

The Bradley-Terry-Luce (BTL) model is a benchmark model for pairwise comparisons between individuals. Despite recent progress on the first-order asymptotics of several popular procedures, the understanding of uncertainty quantification in…

Statistics Theory · Mathematics 2022-08-11 Chao Gao , Yandi Shen , Anderson Y. Zhang

Maximum likelihood or restricted maximum likelihood (REML) estimates of the parameters in linear mixed-effects models can be determined using the lmer function in the lme4 package for R. As for most model-fitting functions in R, the model…

Computation · Statistics 2014-06-24 Douglas Bates , Martin Mächler , Ben Bolker , Steve Walker

Objectives: Highly flexible nonparametric estimators have gained popularity in causal inference and epidemiology. Popular examples of such estimators include targeted maximum likelihood estimators (TMLE) and double machine learning (DML).…

Methodology · Statistics 2024-08-20 Hongxiang Qiu

In health cohort studies, repeated measures of markers are often used to describe the natural history of a disease. Joint models allow to study their evolution by taking into account the possible informative dropout usually due to clinical…

Linear mixed-effects models are widely used in analyzing clustered or repeated measures data. We propose a quasi-likelihood approach for estimation and inference of the unknown parameters in linear mixed-effects models with high-dimensional…

Methodology · Statistics 2021-03-10 Sai Li , Tony T. Cai , Hongzhe Li

In this work we consider data-driven optimization problems where one must maximize a function given only queries at a fixed set of points. This problem setting emerges in many domains where function evaluation is a complex and expensive…

Machine Learning · Computer Science 2021-02-17 Justin Fu , Sergey Levine

This paper develops several interesting, significant, and interconnected approaches to nonparametric or semi-parametric statistical inferences. The overwhelmingly favoured maximum likelihood estimator (MLE) under parametric model is…

Statistics Theory · Mathematics 2023-03-30 Haodi Liang , Jiahua Chen

Multivariate Item Response Theory (MIRT) is sought-after widely by applied researchers looking for interpretable (sparse) explanations underlying response patterns in questionnaire data. There is, however, an unmet demand for such sparsity…

Methodology · Statistics 2025-03-10 Jiguang Li , Robert Gibbons , Veronika Rockova

Empirical economic research frequently applies maximum likelihood estimation in cases where the likelihood function is analytically intractable. Most of the theoretical literature focuses on maximum simulated likelihood (MSL) estimators,…

Econometrics · Economics 2019-08-13 Michael Griebel , Florian Heiss , Jens Oettershagen , Constantin Weiser

The maximum likelihood estimator (MLE) is pivotal in statistical inference, yet its application is often hindered by the absence of closed-form solutions for many models. This poses challenges in real-time computation scenarios,…

Methodology · Statistics 2025-04-16 Pedro L. Ramos , Eduardo Ramos , Francisco A. Rodrigues , Francisco Louzada

This paper proposes a quasi-maximum likelihood (QML) estimator for break points in high-dimensional factor models, specifically accounting for multiple structural breaks. We begin by establishing a necessary and sufficient condition to…

Econometrics · Economics 2026-04-20 Jiangtao Duan , Jushan Bai , Xu Han

Exact MLE for generalized linear mixed models (GLMMs) is a long-standing problem unsolved until today. The proposed research solves the problem. In this problem, the main difficulty is caused by intractable integrals in the likelihood…

Methodology · Statistics 2024-10-14 Tonglin Zhang

We present an asymptotic analysis of Viterbi Training (VT) and contrast it with a more conventional Maximum Likelihood (ML) approach to parameter estimation in Hidden Markov Models. While ML estimator works by (locally) maximizing the…

Machine Learning · Statistics 2013-12-18 Armen E. Allahverdyan , Aram Galstyan

The pattern maximum likelihood (PML) estimate, introduced by Orlitsky et al., is an estimate of the multiset of probabilities in an unknown probability distribution $\mathbf{p}$, the estimate being obtained from $n$ i.i.d. samples drawn…

Discrete Mathematics · Computer Science 2015-06-03 Chun Lam Chan , Winston Fernandes , Navin Kashyap , Manjunath Krishnapur

Evaluating models and datasets in computer vision remains a challenging task, with most leaderboards relying solely on accuracy. While accuracy is a popular metric for model evaluation, it provides only a coarse assessment by considering a…

Computer Vision and Pattern Recognition · Computer Science 2024-09-09 Rahul Ramachandran , Tejal Kulkarni , Charchit Sharma , Deepak Vijaykeerthy , Vineeth N Balasubramanian

Multimodal information retrieval (MMIR) has gained attention for its flexibility in handling text, images, or mixed queries and candidates. Recent breakthroughs in multimodal large language models (MLLMs) boost MMIR performance by…

Information Retrieval · Computer Science 2026-02-27 Dawei Su , Dongsheng Wang