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This work introduces a method to tune a sequence-based generative model for molecular de novo design that through augmented episodic likelihood can learn to generate structures with certain specified desirable properties. We demonstrate how…

Artificial Intelligence · Computer Science 2017-08-30 Marcus Olivecrona , Thomas Blaschke , Ola Engkvist , Hongming Chen

Enzymes are genetically encoded biocatalysts capable of accelerating chemical reactions. How can we automatically design functional enzymes? In this paper, we propose EnzyGen, an approach to learn a unified model to design enzymes across…

Machine Learning · Computer Science 2026-03-03 Zhenqiao Song , Yunlong Zhao , Wenxian Shi , Wengong Jin , Yang Yang , Lei Li

In this work, we perform an exploratory study on synthesizing deep neural networks using biological synaptic strength distributions, and the potential influence of different distributions on modelling performance particularly for the…

Neural and Evolutionary Computing · Computer Science 2017-07-04 A. H. Karimi , M. J. Shafiee , A. Ghodsi , A. Wong

Methods that use neural networks for synthesizing 3D shapes in the form of a part-based representation have been introduced over the last few years. These methods represent shapes as a graph or hierarchy of parts and enable a variety of…

Graphics · Computer Science 2024-09-20 Yanran Guan , Oliver van Kaick

The task of image generation started to receive some attention from artists and designers to inspire them in new creations. However, exploiting the results of deep generative models such as Generative Adversarial Networks can be long and…

Computer Vision and Pattern Recognition · Computer Science 2021-04-05 Baptiste Rozière , Morgane Riviere , Olivier Teytaud , Jérémy Rapin , Yann LeCun , Camille Couprie

Significant progress has been made by the advances in Generative Adversarial Networks (GANs) for image generation. However, there lacks enough understanding of how a realistic image is generated by the deep representations of GANs from a…

Computer Vision and Pattern Recognition · Computer Science 2022-02-03 Bolei Zhou

The choice of parameters, and the design of the network architecture are important factors affecting the performance of deep neural networks. Genetic Algorithms (GA) have been used before to determine parameters of a network. Yet, GAs…

Computer Vision and Pattern Recognition · Computer Science 2018-09-28 Yantao Lu , Burak Kakillioglu , Senem Velipasalar

The harnessing of machine learning, especially deep generative models, has opened up promising avenues in the field of synthetic DNA sequence generation. Whilst Generative Adversarial Networks (GANs) have gained traction for this…

Machine Learning · Computer Science 2023-12-27 Zehui Li , Yuhao Ni , Tim August B. Huygelen , Akashaditya Das , Guoxuan Xia , Guy-Bart Stan , Yiren Zhao

Generative models based on neural networks present a substantial challenge within deep learning. As it stands, such models are primarily limited to the domain of artificial neural networks. Spiking neural networks, as the third generation…

Neural and Evolutionary Computing · Computer Science 2023-05-22 Linghao Feng , Dongcheng Zhao , Yi Zeng

Deep generative modeling has emerged as a powerful tool for synthesizing realistic medical images, driving advances in medical image analysis, disease diagnosis, and treatment planning. This chapter explores various deep generative models…

Image and Video Processing · Electrical Eng. & Systems 2024-10-24 Paul Friedrich , Yannik Frisch , Philippe C. Cattin

Access to genomic data is highly regulated due to its sensitive nature. While safeguards are essential, cumbersome data access processes pose a significant barrier to the development of AI methods for genomics. Synthetic data generation can…

Cryptography and Security · Computer Science 2026-05-01 Daniil Filienko , Martine De Cock , Sikha Pentyala

Semantic segmentation of medical images is pivotal in applications like disease diagnosis and treatment planning. While deep learning has excelled in automating this task, a major hurdle is the need for numerous annotated segmentation…

Image and Video Processing · Electrical Eng. & Systems 2024-09-02 Li Zhang , Basu Jindal , Ahmed Alaa , Robert Weinreb , David Wilson , Eran Segal , James Zou , Pengtao Xie

One of the major prerequisites for any deep learning approach is the availability of large-scale training data. When dealing with scanned document images in real world scenarios, the principal information of its content is stored in the…

Computer Vision and Pattern Recognition · Computer Science 2021-07-12 Sanket Biswas , Pau Riba , Josep Lladós , Umapada Pal

We introduce a new framework for manipulating and interacting with deep generative models that we call network bending. We present a comprehensive set of deterministic transformations that can be inserted as distinct layers into the…

Computer Vision and Pattern Recognition · Computer Science 2021-03-15 Terence Broad , Frederic Fol Leymarie , Mick Grierson

We present a deep generative scene modeling technique for indoor environments. Our goal is to train a generative model using a feed-forward neural network that maps a prior distribution (e.g., a normal distribution) to the distribution of…

Computer Vision and Pattern Recognition · Computer Science 2018-08-08 Zaiwei Zhang , Zhenpei Yang , Chongyang Ma , Linjie Luo , Alexander Huth , Etienne Vouga , Qixing Huang

Deep Neural Networks (DNNs) are built using artificial neural networks. They are part of machine learning methods that are capable of learning from data that have been used in a wide range of applications. DNNs are mainly handcrafted and…

Neural and Evolutionary Computing · Computer Science 2023-04-12 Mohammed Al-Rawi

Generating a photorealistic image with intended human pose is a promising yet challenging research topic for many applications such as smart photo editing, movie making, virtual try-on, and fashion display. In this paper, we present a novel…

Computer Vision and Pattern Recognition · Computer Science 2019-09-19 Wei Sun , Jawadul H. Bappy , Shanglin Yang , Yi Xu , Tianfu Wu , Hui Zhou

Generative concept representations have three major advantages over discriminative ones: they can represent uncertainty, they support integration of learning and reasoning, and they are good for unsupervised and semi-supervised learning. We…

Machine Learning · Computer Science 2018-11-19 Daniel T. Chang

Generating realistic vehicle speed trajectories is a crucial component in evaluating vehicle fuel economy and in predictive control of self-driving cars. Traditional generative models rely on Markov chain methods and can produce accurate…

Machine Learning · Computer Science 2021-12-17 Farnaz Behnia , Dominik Karbowski , Vadim Sokolov

DNA profiles are made up from multiple series of electrophoretic signal measuring fluorescence over time. Typically, human DNA analysts 'read' DNA profiles using their experience to distinguish instrument noise, artefactual signal, and…

Machine Learning · Computer Science 2024-08-30 Duncan Taylor , Melissa Humphries