Related papers: Modeling-based determination of physiological para…
In this paper we develop a simple two compartment model which extends the Farhi equation to the case when the inhaled concentration of a volatile organic compound (VOC) is not zero. The model connects the exhaled breath concentration of…
Recommended standardized procedures for determining exhaled lower respiratory nitric oxide and nasal nitric oxide have been developed by task forces of the European Respiratory Society and the American Thoracic Society. These…
Human breath contains a myriad of endogenous volatile organic compounds (VOCs) which are reflective of ongoing metabolic or physiological processes. While research into the diagnostic potential and general medical relevance of these trace…
Isoprene is one of the most abundant endogenous volatile organic compounds (VOCs) contained in human breath and is considered to be a potentially useful biomarker for diagnostic and monitoring purposes. However, neither the exact…
Isothermal rebreathing has been proposed as an experimental technique for estimating the alveolar levels of hydrophilic volatile organic compounds (VOCs) in exhaled breath. Using the prototypic test compound acetone we demonstrate that the…
Diabetes is a global health burden, and early detection is critical for timely intervention. This study explores a non-invasive, data-driven framework to identify individuals at risk of diabetes using Volatile Organic Compounds (VOCs) and…
We develop a simple three compartment model based on mass balance equations which quantitatively describes the dynamics of breath methane concentration profiles during exercise on an ergometer. With the help of this model it is possible to…
Volatile organic compounds (VOCs) in human breath can reveal a large spectrum of health conditions and can be used for fast, accurate and non-invasive diagnostics. Gas chromatography-mass spectrometry (GC-MS) is used to measure VOCs, but…
Localized vortices can have significant influence on transport of inhaled particles through the upper respiratory tract. These vortices have complex three-dimensional structure with details dependent on the anatomical geometry. Using a…
Viral spread has been intermittently threatening human life over time. Characterizing the viral concentration and modelling the viral transmission are, therefore, considered major milestones for enhancing viral detection capabilities. This…
Exhaled breath can be used in retrieving information and creating innovative communication systems. It contains several volatile organic compounds (VOCs) and biological entities that can act as health biomarkers. For instance, the breath of…
Extending deterministic compartments pharmacokinetic models as diffusions seems not realistic on biological side because paths of these stochastic processes are not smooth enough. In order to extend one compartment intra-veinous bolus…
A real-time recording setup combining exhaled breath VOC measurements by proton transfer reaction mass spectrometry (PTR-MS) with hemodynamic and respiratory data is presented. Continuous automatic sampling of exhaled breath is implemented…
Exhaled breath condensate (EBC) contains volatile metabolites and is promising for non-invasive disease diagnosis, but after decades of research spanning over 100 biomarkers and 10 diseases, no EBC-based test has reached clinical use. The…
When assessing the short term effect of air pollution on health outcomes, it is common practice to consider one pollutant at a time, due to their high correlation. Multi pollutant methods have been recently proposed, mainly consisting of…
We develop a mathematical model of the lung that can estimate independently the air flows and pressures in the upper bronchi. It accounts for the lung multi-scale properties and for the air-tissue interactions. The model equations are…
Dynamic models of occupancy patterns have shown to be effective in optimizing building-systems operations. Previous research has relied on CO$_2$ sensors and vision-based techniques to determine occupancy patterns. Vision-based techniques…
In this paper we present a method for the estimation of leaks in non-invasive ventilation. Accurate estimation of leaks is a key component of a ventilator, since it determines the ventilator performance in terms of patient-ventilator…
Chronic Obstructive Pulmonary Disease (COPD) is a progressive lung disease characterized by airflow limitation. This study develops a systems engineering framework for representing important mechanistic details of COPD in a model of the…
noindent Henry's law constants of the solutes methane, nitrogen, oxygen and carbon dioxide in the solvent ethanol are predicted by molecular simulation. The molecular models for the solutes are taken from previous work. For the solvent…