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We are interested in modeling some two-level population dynamics, resulting from the interplay of ecological interactions and phenotypic variation of individuals (or hosts) and the evolution of cells (or parasites) of two types living in…

Probability · Mathematics 2011-01-21 Sylvie Méléard , Sylvie Roelly

Biological systems are typically highly open, non-equilibrium systems that are very challenging to understand from a statistical mechanics perspective. While statistical treatments of evolutionary biological systems have a long and rich…

Populations and Evolution · Quantitative Biology 2018-08-21 Hamid-Reza Rastegar-Sedehi , Chandrashekar Radhakrishnan , Samer Intissar Nehme , Liev Birman , Paula Velasquez , Tim Byrnes

We have developed and implemented a numerical evolution scheme for a class of stochastic problems in which the temporal evolution occurs on widely-separated time scales, and for which the slow evolution can be described in terms of a small…

Computational Physics · Physics 2009-09-29 S. Setayeshgar , C. W. Gear , H. G. Othmer , I. G. Kevrekidis

The biological theory of adaptive dynamics proposes a description of the long-term evolution of a structured asexual population. It is based on the assumptions of large population, rare mutations and small mutation steps, that lead to a…

Probability · Mathematics 2007-05-23 Nicolas Champagnat , Amaury Lambert

We consider two versions of stochastic population models with mutation and selection. The first approach relies on a multitype branching process; here, individuals reproduce and change type (i.e., mutate) independently of each other,…

Populations and Evolution · Quantitative Biology 2009-02-19 E. Baake , R. Bialowons

We consider a stochastic version of the basic predator-prey differential equation model. The model, which contains a parameter \omega which represents the number of individuals for one unit of prey -- If x denotes the quantity of prey in…

Dynamical Systems · Mathematics 2011-11-29 Fabien Campillo , Claude Lobry

Stochastic dynamics govern many important processes in cellular biology, and an underlying theoretical approach describing these dynamics is desirable to address a wealth of questions in biology and medicine. Mathematical tools exist for…

Quantitative Methods · Quantitative Biology 2016-02-17 Iain G. Johnston , Nick S. Jones

After an introduction to the general topic of models for a given locus of a diploid population whose quadratic dynamics is determined by a fitness landscape, we consider more specifically the models that can be treated using genetic (or…

Populations and Evolution · Quantitative Biology 2016-07-08 Nicolas Grosjean , Thierry Huillet , Geneviève Rollet

Discrete time, spatially extended models play an important role in ecology, modelling population dynamics of species ranging from micro-organisms to birds. An important question is how 'bottom up', individual-based models can be…

Populations and Evolution · Quantitative Biology 2023-01-20 Linnéa Gyllingberg , David J. T. Sumpter , Åke Brännström

A variety of genome transformations can occur as a microbial population adapts to a large environmental change. In particular, genomic surveys indicate that, following the transition to an obligate, host-dependent symbiont, the density of…

Populations and Evolution · Quantitative Biology 2015-03-17 Nicholas Chia , Nigel Goldenfeld

A proper understanding of the links between varying gene expression levels and complex trait adaptation is still lacking, despite recent advances in sequencing techniques leading to new insights on their importance in some evolutionary…

Analysis of PDEs · Mathematics 2022-10-26 Léonard Dekens , Sepideh Mirrahimi

Spreading from a seed is studied by Monte Carlo simulation on a square lattice with two types of sites affecting the rates of birth and death. These systems exhibit a critical transition between survival and extinction. For time- dependent…

Disordered Systems and Neural Networks · Physics 2009-11-07 Gyorgy Szabo , Hajnalka Gergely , Beata Oborny

To forecast the time dynamics of an epidemic, we propose a discrete stochastic model that unifies and generalizes previous approaches to the subject. Viewing a given population of individuals or groups of individuals with given health state…

Populations evolving under the joint influence of recombination and resampling (traditionally known as genetic drift) are investigated. First, we summarise and adapt a deterministic approach, as valid for infinite populations, which assumes…

Populations and Evolution · Quantitative Biology 2009-02-20 Ellen Baake , Inke Herms

We consider a model for Darwinian evolution in an asexual population with a large but non-constant populations size characterized by a natural birth rate, a logistic death rate modelling competition and a probability of mutation at each…

Probability · Mathematics 2015-08-28 Martina Baar , Anton Bovier , Nicolas Champagnat

We present a stochastic approach to modeling the dynamics of coexistence of prey and predator populations. It is assumed that the space of coexistence is explicitly subdivided in a grid of cells. Each cell can be occupied by only one…

Populations and Evolution · Quantitative Biology 2015-06-26 Kelly C. de Carvalho , Tania Tome

We study a simple solvable model describing the genesis of monomer sequences for hetero-polymers (such as proteins), as the result of the equilibration of a slow stochastic genetic selection process which is assumed to be driven by the…

Disordered Systems and Neural Networks · Physics 2007-05-23 H. Chakravorty , A. C. C. Coolen , D. Sherrington

Models of coevolution have recently been studied, in which a species is defined by a genome in the form of a bitstring, and the interactions between species i and j are given by a fixed matrix with independent, randomly distributed elements…

Populations and Evolution · Quantitative Biology 2007-05-23 Volkan Sevim , Per Arne Rikvold

Developments in transcriptomics techniques have caused a large demand in tailored computational methods for modelling gene expression dynamics from experimental data. Recently, so-called single-cell experiments have revolutionised genetic…

Quantitative Methods · Quantitative Biology 2019-03-18 Atte Aalto , Jorge Goncalves

Genetic variation in a population can sometimes arise so fast as to modify ecosystem dynamics. Such phenomena have been observed in natural predator-prey systems, and characterized in the laboratory as showing unusual phase relationships in…

Populations and Evolution · Quantitative Biology 2025-03-25 Hong-Yan Shih , Nigel Goldenfeld
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