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Recent genomic foundation models largely adopt large language model architectures that treat DNA as a one-dimensional token sequence. However, exhaustive sequential reading is structurally misaligned with sparse and discontinuous genomic…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Hongxin Xiang , Pengsen Ma , Yunkang Cao , Di Yu , Haowen Chen , Xinyu Yang , Xiangxiang Zeng

Steganography algorithms facilitate communication between a source and a destination in a secret manner. This is done by embedding messages/text/data into images without impacting the appearance of the resultant images/videos. Steganalysis…

Computer Vision and Pattern Recognition · Computer Science 2020-10-20 Farid Ghareh Mohammadi , Farzan Shenavarmasouleh , M. Hadi Amini , Hamid R. Arabnia

Genetic information is encoded in a linear sequence of nucleotides, represented by letters ranging from thousands to billions. Mutations refer to changes in the DNA or RNA nucleotide sequence. Thus, mutation detection is vital in all areas…

The genetic code is the set of rules by which information encoded in genetic material (DNA or RNA sequences) is translated into proteins (amino acid sequences) by living cells. The code defines a mapping between tri-nucleotide sequences,…

Other Quantitative Biology · Quantitative Biology 2015-12-03 Jayanta Kumar Das , Atrayee Majumder , Pabitra Pal Choudhury

DNA-based data storage has been attracting significant attention due to its extremely high data storage density, low power consumption, and long duration compared to conventional data storage media. Despite the recent advancements in DNA…

Information Theory · Computer Science 2024-11-12 Yi Ding , Xuan He , Tuan Thanh Nguyen , Wentu Song , Zohar Yakhini , Eitan Yaakobi , Linqiang Pan , Xiaohu Tang , Kui Cai

In this paper, we consider recommender systems with side information in the form of graphs. Existing collaborative filtering algorithms mainly utilize only immediate neighborhood information and have a hard time taking advantage of deeper…

Machine Learning · Computer Science 2019-05-30 Liwei Wu , Hsiang-Fu Yu , Nikhil Rao , James Sharpnack , Cho-Jui Hsieh

In the post-genomic era, large-scale personal DNA sequences are produced and collected for genetic medical diagnoses and new drug discovery, which, however, simultaneously poses serious challenges to the protection of personal genomic…

Cryptography and Security · Computer Science 2017-08-10 Shibiao Wan , Man-Wai Mak , Sun-Yuan Kung

Whereas cryptography easily arouses attacks by means of encrypting a secret message into a suspicious form, steganography is advantageous for its resilience to attacks by concealing the message in an innocent-looking cover signal. Minimal…

Cryptography and Security · Computer Science 2022-10-27 Kejiang Chen , Hang Zhou , Yaofei Wang , Menghan Li , Weiming Zhang , Nenghai Yu

Graph clustering aims to divide the graph into different clusters. The recently emerging deep graph clustering approaches are largely built on graph neural networks (GNN). However, GNN is designed for general graph encoding and there is a…

Machine Learning · Computer Science 2025-04-28 Zhiyuan Ning , Zaitian Wang , Ran Zhang , Ping Xu , Kunpeng Liu , Pengyang Wang , Wei Ju , Pengfei Wang , Yuanchun Zhou , Erik Cambria , Chong Chen

DNA storage is now being considered as a new archival storage method for its durability and high information density, but still facing some challenges like high costs and low throughput. By reducing sequencing sample size for decoding…

Information Theory · Computer Science 2025-04-22 Ruiying Cao , Xin Chen

Convolutional codes are error-correcting linear codes that utilize shift registers to encode. These codes have an arbitrary block size and they can incorporate both past and current information bits. DNA codes represent DNA sequences and…

Information Theory · Computer Science 2021-11-09 Paridhi Latawa , Nuh Aydin

DNA has immense potential as an emerging data storage medium. The principle of DNA storage is the conversion and flow of digital information between binary code stream, quaternary base, and actual DNA fragments. This process will inevitably…

Information Retrieval · Computer Science 2022-10-21 Yun Qin , Fei Zhu , Bo Xi

The vast parallelism, exceptional energy efficiency and extraordinary information inherent in DNA molecules are being explored for computing, data storage and cryptography. DNA cryptography is a emerging field of cryptography. In this paper…

Cryptography and Security · Computer Science 2011-01-14 D. Prabhu , M. Adimoolam

Composite DNA is a recent novel method to increase the information capacity of DNA-based data storage above the theoretical limit of 2 bits/symbol. In this method, every composite symbol does not store a single DNA nucleotide but a mixture…

Information Theory · Computer Science 2025-01-22 Tuan Thanh Nguyen , Chen Wang , Kui Cai , Yiwei Zhang , Zohar Yakhini

Most previous work on neural text generation from graph-structured data relies on standard sequence-to-sequence methods. These approaches linearise the input graph to be fed to a recurrent neural network. In this paper, we propose an…

Computation and Language · Computer Science 2018-10-24 Diego Marcheggiani , Laura Perez-Beltrachini

Predicting DNA-protein binding is an important and classic problem in bioinformatics. Convolutional neural networks have outperformed conventional methods in modeling the sequence specificity of DNA-protein binding. However, none of the…

Genomics · Quantitative Biology 2021-06-04 Yuhang Guo , Xiao Luo , Liang Chen , Minghua Deng

Genome modeling conventionally treats gene sequence as a language, reflecting its structured motifs and long-range dependencies analogous to linguistic units and organization principles such as words and syntax. Recent studies utilize…

Machine Learning · Computer Science 2025-05-06 Lei Mao , Yuanhe Tian , Yan Song

Complexity metrics and machine learning (ML) models have been utilized to analyze the lengths of segmental genomic entities like: exons, introns, intergenic and repeat/unique DNA sequences, in each of the 22 human chromosomes. The purpose…

Current research on DNA storage usually focuses on the improvement of storage density by developing effective encoding and decoding schemes while lacking the consideration on the uncertainty in ultra-long-term data storage and retention.…

Emerging Technologies · Computer Science 2022-08-10 Min Li , Jiashu Wu , Junbiao Dai , Qingshan Jiang , Qiang Qu , Xiaoluo Huang , Yang Wang

Due to its longevity and enormous information density, DNA is an attractive medium for archival data storage. Thanks to rapid technological advances, DNA storage is becoming practically feasible, as demonstrated by a number of experimental…

Information Theory · Computer Science 2022-11-11 Ilan Shomorony , Reinhard Heckel
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