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Scalable production of all-electronic DNA biosensors with high sensitivity and selectivity is a critical enabling step for research and applications associated with detection of DNA hybridization. We have developed a scalable and very…

Applied Physics · Physics 2017-08-31 Jinglei Ping , Ramya Vishnubhotla , Amey Vrudhula , A. T. Charlie Johnson

The rapid and global spread of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), underscored the urgent need for fast, reliable, and adaptable diagnostic tools capable of…

We have developed a novel, all-electronic biosensor for opioids that consists of an engineered mu opioid receptor protein, with high binding affinity for opioids, chemically bonded to a graphene field-effect transistor to read out ligand…

Graphene Field-Effect Transistors (GFETs) are increasingly employed as biochemical sensors due to their exceptional electronic properties, surface sensitivity, and potential for miniaturization. A critical challenge in deploying GFETs is…

Graphene field effect transistors (G-FETs) have appeared as suitable candidates for sensing charges and have thus attracted large interest for ion and chemical detections. In particular, their high sensitivity, chemical robustness,…

Mesoscale and Nanoscale Physics · Physics 2024-02-08 Océane Terral , Guillaume Audic , Arnaud Claudel , Justine Magnat , Aurélie Dupont , Christophe J. Moreau , Cécile Delacour

This report describes the development of an aptamer for sensing azole antifungal drugs for therapeutic drug monitoring. Modified Synthetic Evolution of Ligands through Exponential Enrichment (SELEX) was used to discover a DNA aptamer…

The reliability of analysis is becoming increasingly important as point-of-care diagnostics are transitioning from single analyte detection towards multiplexed multianalyte detection. Multianalyte detection benefits greatly from…

Graphene field-effect transistors (GFETs) are among the most promising platforms for ultrasensitive chemical and biological sensing due to their high carrier mobility, large surface area, and low intrinsic noise. However, conventional…

Applied Physics · Physics 2025-09-05 Vinay Kammarchedu , Heshmat Asgharian , Hossein Chenani , Aida Ebrahimi

In this paper, we present the design and the analysis of an electrochemical circuit for measuring the concentrations of therapeutic drugs using structure-switching aptamers. Aptamers are single-stranded nucleic acids, whose sequence is…

Signal Processing · Electrical Eng. & Systems 2020-05-08 Jun-Chau Chien , Sam W. Baker , H. Tom Soh , Amin Arbabian

A 200 mm processing platform for the large-scale production of graphene field-effect transistor-quantum dot (GFET-QD) hybrid photodetectors is demonstrated. Comprehensive statistical analysis of electric data shows a high yield (96%) and…

With the growing interest in graphene field-effect transistors (GFETs) for biosensing applications, there is a strong demand for strategies enabling flexible and multiplexed biofunctionalization, as well as highly parallel, real-time…

Dynamic wavelength tunability has long been the holy grail of photodetector technology. Because of its atomic thickness and unique properties, graphene opens up new paradigms to realize this concept, but so far this has been elusive…

Mesoscale and Nanoscale Physics · Physics 2017-03-08 François Léonard , Catalin D. Spataru , Michael Goldflam , David W. Peters , Thomas E. Beechem

Dielectrophoretic (DEP) sensing is an extremely important sensing modality that enables the rapid capture and detection of polarizable particles of nano-scale size. This makes it a versatile tool for applications in medical diagnostics,…

Mesoscale and Nanoscale Physics · Physics 2025-11-26 Nezhueyotl Izquierdo , Ruixue Li , Peter R. Christenson , Sang-Hyun Oh , Steven J. Koester

Spectacular advances in heterodyne astronomy with both the Herschel Space Observatory and Stratospheric Observatory for Far Infrared Astronomy (SOFIA) have been largely due to breakthroughs in detector technology. In order to exploit the…

Mesoscale and Nanoscale Physics · Physics 2019-10-01 S. Lara-Avila , A. Danilov , D. Golubev , H. He , K. H. Kim , R. Yakimova , F. Lombardi , T. Bauch , S. Cherednichenko , S. Kubatkin

The application of imaging techniques based on ensembles of nitrogen-vacancy (NV) sensors in diamond to characterise electrical devices has been proposed, but the compatibility of NV sensing with operational gated devices remains largely…

Silicon nanochannel field effect transistor (FET) biosensors are one of the most promising technologies in the development of highly sensitive and label-free analyte detection for cancer diagnostics. With their exceptional electrical…

Quantitative Methods · Quantitative Biology 2014-01-07 Pritiraj Mohanty , Yu Chen , Xihua Wang , Mi K. Hong , Carol L. Rosenberg , David T. Weaver , Shyamsunder Erramilli

The unique optoelectronic properties of graphene [1] make it an ideal platform for a variety of photonic applications [2], including fast photodetectors [3], transparent electrodes [4], optical modulators [5], and ultra-fast lasers [6].…

Mesoscale and Nanoscale Physics · Physics 2012-10-02 L. Vicarelli , M. S. Vitiello , D. Coquillat , A. Lombardo , A. C. Ferrari , W. Knap , M. Polini , V. Pellegrini , A. Tredicucci

We propose a water-immersed nucleobase-functionalized suspended graphene nanoribbon as an intrinsically selective device for nucleotide detection. The proposed sensing method combines Watson-Crick selective base pairing with graphene's…

Mesoscale and Nanoscale Physics · Physics 2016-02-17 Eugene Paulechka , Tsjerk A. Wassenaar , Kenneth Kroenlein , Andrei Kazakov , Alex Smolyanitsky

Mycotoxins comprise a frequent type of toxins present in food and feed. The problem of mycotoxin contamination has been recently aggravated due to the increased complexity of the farm-to-fork chains, resulting in negative effects on human…

Electrical detection of messenger ribonucleic acid (mRNA) is a promising approach to enhancing transcriptomics and disease diagnostics because of its sensitivity, rapidity, and modularity. Reported here is a fast SARS-CoV-2 mRNA biosensor…

Biomolecules · Quantitative Biology 2022-05-12 Nicholas E. Fuhr , Mohamed Azize , David J. Bishop
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