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Spectral computed tomography (CT) is an emerging technology capable of providing high chemical specificity, which is crucial for many applications such as detecting threats in luggage. This type of application requires both fast and…

Image and Video Processing · Electrical Eng. & Systems 2021-03-30 Wail Mustafa , Christian Kehl , Ulrik Lund Olsen , Søren Kimmer Schou Gregersen , David Malmgren-Hansen , Jan Kehres , Anders Bjorholm Dahl

The ability to synthesise Computed Tomography images - commonly known as pseudo CT, or pCT - from MRI input data is commonly assessed using an intensity-wise similarity, such as an L2-norm between the ground truth CT and the pCT. However,…

Image and Video Processing · Electrical Eng. & Systems 2020-04-15 Kerstin Kläser , Thomas Varsavsky , Pawel Markiewicz , Tom Vercauteren , David Atkinson , Kris Thielemans , Brian Hutton , M Jorge Cardoso , Sebastien Ourselin

Low Dose CT Denoising research aims to reduce the risks of radiation exposure to patients. Recently researchers have used deep learning to denoise low dose CT images with promising results. However, approaches that use mean-squared-error…

Image and Video Processing · Electrical Eng. & Systems 2024-09-05 Sepehr Ataei , Javad Alirezaie , Paul Babyn

Digital breast tomosynthesis (DBT) exams should utilize the lowest possible radiation dose while maintaining sufficiently good image quality for accurate medical diagnosis. In this work, we propose a convolution neural network (CNN) to…

Image and Video Processing · Electrical Eng. & Systems 2022-03-23 Rodrigo de Barros Vimieiro , Chuang Niu , Hongming Shan , Lucas Rodrigues Borges , Ge Wang , Marcelo Andrade da Costa Vieira

Positron Emission Tomography (PET) is a functional imaging modality widely used in neuroscience studies. To obtain meaningful quantitative results from PET images, attenuation correction is necessary during image reconstruction. For PET/MR…

Medical Physics · Physics 2018-08-01 Kuang Gong , Jaewon Yang , Kyungsang Kim , Georges El Fakhri , Youngho Seo , Quanzheng Li

We present a method that lowers the dose required for a ptychographic reconstruction by adaptively scanning the specimen, thereby providing the required spatial information redundancy in the regions of highest importance. The proposed…

Computational Physics · Physics 2022-03-30 Marcel Schloz , Johannes Müller , Thomas C. Pekin , Wouter Van den Broek , Christoph T. Koch

A major challenge in computed tomography (CT) is to reduce X-ray dose to a low or even ultra-low level while maintaining the high quality of reconstructed images. We propose a new method for CT reconstruction that combines penalized…

Machine Learning · Statistics 2017-07-11 Xuehang Zheng , Zening Lu , Saiprasad Ravishankar , Yong Long , Jeffrey A. Fessler

PET is affected by statistical noise due to constraints on tracer dose and scan duration, impacting both diagnostic performance and quantitative accuracy. While deep learning (DL)-based PET denoising methods have been used to improve image…

Reconstruction of CT images from a limited set of projections through an object is important in several applications ranging from medical imaging to industrial settings. As the number of available projections decreases, traditional…

Computer Vision and Pattern Recognition · Computer Science 2022-01-25 Anish Lahiri , Marc Klasky , Jeffrey A. Fessler , Saiprasad Ravishankar

Low-dose CT image reconstruction has been a popular research topic in recent years. A typical reconstruction method based on post-log measurements is called penalized weighted-least squares (PWLS). Due to the underlying limitations of the…

Signal Processing · Electrical Eng. & Systems 2019-08-13 Siqi Ye , Saiprasad Ravishankar , Yong Long , Jeffrey A. Fessler

Low-dose computed tomography (LDCT) offers significant advantages in reducing the potential harm to human bodies. However, reducing the X-ray dose in CT scanning often leads to severe noise and artifacts in the reconstructed images, which…

Image and Video Processing · Electrical Eng. & Systems 2024-08-27 Ran An , Yinghui Zhang , Xi Chen , Lemeng Li , Ke Chen , Hongwei Li

Low-dose computed tomography (CT) has attracted a major attention in the medical imaging field, since CT-associated x-ray radiation carries health risks for patients. The reduction of CT radiation dose, however, compromises the…

Computer Vision and Pattern Recognition · Computer Science 2019-07-16 Hongming Shan , Yi Zhang , Qingsong Yang , Uwe Kruger , Mannudeep K. Kalra , Ling Sun , Wenxiang Cong , Ge Wang

Image reconstruction in low-count PET is particularly challenging because gammas from natural radioactivity in Lu-based crystals cause high random fractions that lower the measurement signal-to-noise-ratio (SNR). In model-based image…

Image and Video Processing · Electrical Eng. & Systems 2020-05-27 Hongki Lim , Il Yong Chun , Yuni K. Dewaraja , Jeffrey A. Fessler

Low-dose computed tomography (LDCT) plays a vital role in clinical applications by mitigating radiation risks. Nevertheless, reducing radiation doses significantly degrades image quality. Concurrently, common deep learning methods demand…

Image and Video Processing · Electrical Eng. & Systems 2024-05-28 Wenhao Zhang , Bin Huang , Shuyue Chen , Xiaoling Xu , Weiwen Wu , Qiegen Liu

Positron Emission Tomography (PET) is an important clinical imaging tool but inevitably introduces radiation hazards to patients and healthcare providers. Reducing the tracer injection dose and eliminating the CT acquisition for attenuation…

Computer Vision and Pattern Recognition · Computer Science 2024-06-18 Tianqi Chen , Jun Hou , Yinchi Zhou , Huidong Xie , Xiongchao Chen , Qiong Liu , Xueqi Guo , Menghua Xia , James S. Duncan , Chi Liu , Bo Zhou

In portable, three dimensional, and ultra-fast ultrasound imaging systems, there is an increasing demand for the reconstruction of high quality images from a limited number of radio-frequency (RF) measurements due to receiver (Rx) or…

Computer Vision and Pattern Recognition · Computer Science 2018-08-08 Yeo Hun Yoon , Shujaat Khan , Jaeyoung Huh , Jong Chul Ye

Long axial field-of-view PET scanners offer increased field-of-view and sensitivity compared to traditional PET scanners. However, a significant cost is associated with the densely packed photodetectors required for the extended-coverage…

Image and Video Processing · Electrical Eng. & Systems 2025-11-12 Klara Leffler , Luigi Tommaso Luppino , Samuel Kuttner , Karin Söderkvist , Jan Axelsson

Low-dose computed tomography (LDCT) is critical for minimizing radiation exposure, but it often leads to increased noise and reduced image quality. Traditional denoising methods, such as iterative optimization or supervised learning, often…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Debopom Sutradhar , Ripon Kumar Debnath , Mohaimenul Azam Khan Raiaan , Yan Zhang , Reem E. Mohamed , Sami Azam

Recent work has shown improved lesion detectability and flexibility to reconstruction hyperparameters (e.g. scanner geometry or dose level) when PET images are reconstructed by leveraging pre-trained diffusion models. Such methods train a…

Medical Physics · Physics 2025-08-28 George Webber , Alexander Hammers , Andrew P. King , Andrew J. Reader

Multi-energy CT takes advantage of the non-linearly varying attenuation properties of elemental media with respect to energy, enabling more precise material identification than single-energy CT. The increased precision comes with the cost…

Medical Physics · Physics 2020-02-14 Jussi Toivanen , Alexander Meaney , Samuli Siltanen , Ville Kolehmainen