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Massive exploitation of next-generation sequencing technologies requires dealing with both: huge amounts of data and complex bioinformatics pipelines. Computing architectures have evolved to deal with these problems, enabling approaches…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-07-07 Aaron Call , Jordà Polo , David Carrera , Francesc Guim , Sujoy Sen

A basic task in bioinformatics is the counting of $k$-mers in genome strings. The $k$-mer counting problem is to build a histogram of all substrings of length $k$ in a given genome sequence. We present the open source $k$-mer counting…

Data Structures and Algorithms · Computer Science 2016-07-25 Marius Erbert , Steffen Rechner , Matthias Müller-Hannemann

A major challenge in next-generation genome sequencing (NGS) is to assemble massive overlapping short reads that are randomly sampled from DNA fragments. To complete assembling, one needs to finish a fundamental task in many leading…

Genomics · Quantitative Biology 2015-05-26 Yang Li , XifengYan

Motivation: Building the histogram of occurrences of every $k$-symbol long substring of nucleotide data is a standard step in many bioinformatics applications, known under the name of $k$-mer counting. Its applications include developing de…

Data Structures and Algorithms · Computer Science 2017-03-03 Sebastian Deorowicz , Marek Kokot , Szymon Grabowski , Agnieszka Debudaj-Grabysz

Kernel matrix-vector multiplication (KMVM) is a foundational operation in machine learning and scientific computing. However, as KMVM tends to scale quadratically in both memory and time, applications are often limited by these…

Numerical Analysis · Mathematics 2025-02-25 Robert Hu , Siu Lun Chau , Dino Sejdinovic , Joan Alexis Glaunès

Machine learning algorithms are becoming increasingly prevalent and performant in the reconstruction of events in accelerator-based neutrino experiments. These sophisticated algorithms can be computationally expensive. At the same time, the…

We improve on GenASM, a recent algorithm for genomic sequence alignment, by significantly reducing its memory footprint and bandwidth requirement. Our algorithmic improvements reduce the memory footprint by 24$\times$ and the number of…

Hardware Architecture · Computer Science 2022-03-30 Joël Lindegger , Damla Senol Cali , Mohammed Alser , Juan Gómez-Luna , Onur Mutlu

The rise of LLMs has driven demand for private serverless deployments, characterized by moderate-sized models and infrequent requests. While existing serverless solutions follow exclusive GPU allocation, we take a step back to explore…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-12-16 Chuhao Xu , Zijun Li , Quan Chen , Han Zhao , Xueyan Tang , Minyi Guo

Genomic sequence alignment is an important research topic in bioinformatics and continues to attract significant efforts. As genomic data grow exponentially, however, most of alignment methods face challenges due to their huge computational…

Computational Engineering, Finance, and Science · Computer Science 2018-06-07 Hanyu Jiang , Narayan Ganesan , Yu-Dong Yao

In generating large quantities of DNA data, high-throughput sequencing technologies require advanced bioinformatics infrastructures for efficient data analysis. k-mer counting, the process of quantifying the frequency of fixed-length k DNA…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-07-11 Yifan Li , Giulia Guidi

The Kernel Polynomial Method (KPM) is one of the fast diagonalization methods used for simulations of quantum systems in research fields of condensed matter physics and chemistry. The algorithm has a difficulty to be parallelized on a…

Computational Physics · Physics 2011-05-30 Shixun Zhang , Shinichi Yamagiwa , Masahiko Okumura , Seiji Yunoki

DNA sequencing is the physical/biochemical process of identifying the location of the four bases (Adenine, Guanine, Cytosine, Thymine) in a DNA strand. As semiconductor technology revolutionized computing, modern DNA sequencing technology…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-05-06 S. Karen Khatamifard , Zamshed Chowdhury , Nakul Pande , Meisam Razaviyayn , Chris Kim , Ulya R. Karpuzcu

General matrix multiplication (GEMM) operations are the fundamental building blocks of computational domains including artificial intelligence (AI). As GPU architectures evolve and high-performance AI becomes increasingly important,…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-11-26 Harisankar Sadasivan , Muhammed Emin Ozturk , Muhammad Osama , Chris Millette , Astha Rai , Maksim Podkorytov , John Afaganis , Carlus Huang , Jing Zhang , Jun Liu

Quantized Spiking Neural Networks (QSNNs) offer superior energy efficiency and are well-suited for deployment on resource-limited edge devices. However, limited bit-width weight and membrane potential result in a notable performance…

Neural and Evolutionary Computing · Computer Science 2025-03-04 Dehao Zhang , Shuai Wang , Yichen Xiao , Wenjie Wei , Yimeng Shan , Malu Zhang , Yang Yang

Modern computing platforms tend to deploy multiple GPUs (2, 4, or more) on a single node to boost system performance, with each GPU having a large capacity of global memory and streaming multiprocessors (SMs). GPUs are an expensive…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-07-20 Chao Chen , Chris Porter , Santosh Pande

Modern transformer-based Large Language Models (LLMs) are constructed with a series of decoder blocks. Each block comprises three key components: (1) QKV generation, (2) multi-head attention, and (3) feed-forward networks. In batched…

Hardware Architecture · Computer Science 2024-06-21 Guseul Heo , Sangyeop Lee , Jaehong Cho , Hyunmin Choi , Sanghyeon Lee , Hyungkyu Ham , Gwangsun Kim , Divya Mahajan , Jongse Park

Deep Neural Networks (DNNs) have revolutionized various fields, but their deployment on GPUs often leads to significant energy consumption. Unlike existing methods for reducing GPU energy consumption, which are either hardware-inflexible or…

Performance · Computer Science 2024-12-02 Yijia Zhang , Zhihong Gou , Shijie Cao , Weigang Feng , Sicheng Zhang , Guohao Dai , Ningyi Xu

This problem was solved within the framework of the grant project "Solving of problems of cluster analysis with application of parallel algorithms and cloud technologies" in the Institute of Mathematics and Mathematical Modelling in Almaty.…

Distributed, Parallel, and Cluster Computing · Computer Science 2014-02-18 Natalya Litvinenko

In this paper we implemented the algorithm we developed in [1] called 3DPIFCM in a parallel environment by using CUDA on a GPU. In our previous work we introduced 3DPIFCM which performs segmentation of images in noisy conditions and uses…

Computer Vision and Pattern Recognition · Computer Science 2020-02-07 Arie Agranonik , Maya Herman , Mark Last

Graph Neural Networks (GNNs) are becoming a promising technique in various domains due to their excellent capabilities in modeling non-Euclidean data. Although a spectrum of accelerators has been proposed to accelerate the inference of…

Hardware Architecture · Computer Science 2023-11-17 Zeyu Zhu , Fanrong Li , Gang Li , Zejian Liu , Zitao Mo , Qinghao Hu , Xiaoyao Liang , Jian Cheng
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