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We propose a two-sample test for detecting the difference between mean vectors in a high-dimensional regime based on a ridge-regularized Hotelling's $T^2$. To choose the regularization parameter, a method is derived that aims at maximizing…

Methodology · Statistics 2018-02-20 Haoran Li , Alexander Aue , Debashis Paul , Jie Peng , Pei Wang

Hotelling's $T^2$ test is a classical approach for discriminating the means of two multivariate normal samples that share a population covariance matrix. Hotelling's test is not ideal for high-dimensional samples because the eigenvalues of…

Statistics Theory · Mathematics 2022-06-07 Benjamin D. Robinson , Robert Malinas , Van Latimer , Beth Bjorkman Morrison , Alfred O. Hero

For high-dimensional small sample size data, Hotelling's T2 test is not applicable for testing mean vectors due to the singularity problem in the sample covariance matrix. To overcome the problem, there are three main approaches in the…

Methodology · Statistics 2020-03-11 Zongliang Hu , Tiejun Tong , Marc G. Genton

Hotelling's $T^2$-test for the mean of a multivariate normal distribution is one of the triumphs of classical multivariate analysis. It is uniformly most powerful among invariant tests, and admissible, proper Bayes, and locally and…

Statistics Theory · Mathematics 2019-10-10 Michael D. Perlman

We investigate covariance shrinkage for Hotelling's $T^2$ in the regime where the data dimension $p$ and the sample size $n$ grow in a fixed ratio -- without assuming that the population covariance matrix is spiked or well-conditioned. When…

Statistics Theory · Mathematics 2025-06-13 Benjamin D. Robinson , Van Latimer

We discuss a one-sample location test that can be used in the case of high-dimensional data. For high-dimensional data, the power of Hotelling's test decrises when the dimension is close to the sample size. To address this loss of power,…

Statistics Theory · Mathematics 2014-05-13 Masashi Hyodo , Takahiro Nishiyama

In paired design studies, it is common to have multiple measurements taken for the same set of subjects under different conditions. In observational studies, it is many times of interest to conduct pair matching on multiple covariates…

Methodology · Statistics 2021-09-21 Jingru Zhang , Hao Chen , Xiao-Hua Zhou

Hotelling's T-squared test is a classical tool to test if the normal mean of a multivariate normal distribution is a specified one or the means of two multivariate normal means are equal. When the population dimension is higher than the…

Statistics Theory · Mathematics 2021-08-17 Tiefeng Jiang , Ping Li

In high dimensions, the classical Hotelling's $T^2$ test tends to have low power or becomes undefined due to singularity of the sample covariance matrix. In this paper, this problem is overcome by projecting the data matrix onto lower…

Methodology · Statistics 2014-05-09 Radhendushka Srivastava , Ping Li , David Ruppert

Designed gene expression micro-array experiments, consisting of several treatment levels with a number of replicates per level, are analyzed by applying simple tests for group differences at the per gene level. The gene level statistics are…

Methodology · Statistics 2017-12-11 Grant Izmirlian

A Cramer moderate deviation theorem for Hotelling's $T^2$-statistic is proved under a finite $(3+\delta)$th moment. The result is applied to large scale tests on the equality of mean vectors and is shown that the number of tests can be as…

Statistics Theory · Mathematics 2013-04-09 Weidong Liu , Qi-Man Shao

This paper is motivated by the analysis of gene expression sets, especially by finding differentially expressed gene sets between two phenotypes. Gene $\log_2$ expression levels are highly correlated and, very likely, have approximately…

Other Statistics · Statistics 2010-07-08 Peter Bubeliny

We study the problem of detecting multiple change points in the mean vectors of an independent sequence of high-dimensional observations. We propose a family of ridge-regularized CUSUM statistics built upon the adaptable ridge-regularized…

Methodology · Statistics 2026-05-26 Haoran Li , Haotian Xu

We consider the hypothesis testing problem of detecting a shift between the means of two multivariate normal distributions in the high-dimensional setting, allowing for the data dimension p to exceed the sample size n. Specifically, we…

Statistics Theory · Mathematics 2015-09-15 Miles E. Lopes , Laurent J. Jacob , Martin J. Wainwright

We consider Hotelling's T^2 statistic for an arbitrary d-dimensional sample. If the sampling is not too deterministic or inhomogeneous, then under zero means hypothesis, T^2 tends to \chi^2_d in distribution. We show that a test for the…

Statistics Theory · Mathematics 2007-06-13 Iosif Pinelis

It has been a long history in testing whether a mean vector with a fixed dimension has a specified value. Some well-known tests include the Hotelling $T^2$-test and the empirical likelihood ratio test proposed by Owen [Biometrika 75 (1988)…

Methodology · Statistics 2014-05-21 Liang Peng , Yongcheng Qi , Fang Wang

We propose a two-sample test for the means of high-dimensional data when the data dimension is much larger than the sample size. Hotelling's classical $T^2$ test does not work for this "large $p$, small $n$" situation. The proposed test…

Statistics Theory · Mathematics 2010-02-25 Song Xi Chen , Ying-Li Qin

In this paper we prove the central limit theorem for Hotelling's $T^2$ statistic when the dimension of the random vectors is proportional to the sample size.

Probability · Mathematics 2012-01-10 G. M. Pan , W. Zhou

We propose a method of testing the shift between mean vectors of two multivariate Gaussian random variables in a high-dimensional setting incorporating the possible dependency and allowing $p > n$. This method is a combination of two…

Methodology · Statistics 2019-12-24 Tzviel Frostig , Yoav Benjamini

In this paper, we discuss tests for mean vector of high-dimensional data when the dimension $p$ is a function of sample size $n$. One of the tests, called the decomposite $T^{2}$-test, in the high-dimensional testing problem is constructed…

Statistics Theory · Mathematics 2024-03-05 Chia-Hsuan Tsai , Ming-Tien Tsai
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