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Directed evolution is an iterative laboratory process of designing proteins with improved function by iteratively synthesizing new protein variants and evaluating their desired property with expensive and time-consuming biochemical…

Machine Learning · Computer Science 2025-09-08 Matouš Soldát , Jiří Kléma

Despite the tremendous successes of science in providing knowledge and technologies, the Replication Crisis has highlighted that scientific institutions have much room for improvement. Peer-review is one target of criticism and suggested…

Theoretical Economics · Economics 2020-11-17 Mantas Radzvilas , Francesco De Pretis , William Peden , Daniele Tortoli , Barbara Osimani

Evolutionary algorithms have been used in the digital art scene since the 1970s. A popular application of genetic algorithms is to optimize the procedural placement of vector graphic primitives to resemble a given painting. In recent years,…

Neural and Evolutionary Computing · Computer Science 2022-01-31 Yingtao Tian , David Ha

In this pilot study, we investigate the use of GPT4 to assist in the peer-review process. Our key hypothesis was that GPT-generated reviews could achieve comparable helpfulness to human reviewers. By comparing reviews generated by both…

Human-Computer Interaction · Computer Science 2023-07-13 Zachary Robertson

Genetic fitness optimization using small populations or small population updates across generations generally suffers from randomly diverging evolutions. We propose a notion of highly probable fitness optimization through feasible…

Neural and Evolutionary Computing · Computer Science 2007-05-23 Paul Vitanyi

Autonomous research agents can already run machine learning experiments without human supervision, but many rely on a narrow search strategy: they repeatedly modify one program and keep changes only when they improve the current best…

Neural and Evolutionary Computing · Computer Science 2026-05-15 Ahmadreza Jeddi , Minh Ngoc Le , Hakki C. Karaimer , Konstantinos G. Derpanis , Babak Taati

This paper presents Automatic Algorithm Discoverer (AAD), an evolutionary framework for synthesizing programs of high complexity. To guide evolution, prior evolutionary algorithms have depended on fitness (objective) functions, which are…

Neural and Evolutionary Computing · Computer Science 2019-04-08 Ruchira Sasanka , Konstantinos Krommydas

We present a two-stage pipeline for AI-assisted improvement of published algorithm implementations. In the first stage, a large language model with research capabilities identifies recently published algorithms satisfying explicit…

Software Engineering · Computer Science 2026-04-16 Worasait Suwannik

Gene expression programming is an evolutionary optimization algorithm with the potential to generate interpretable and easily implementable equations for regression problems. Despite knowledge gained from previous optimizations being…

Neural and Evolutionary Computing · Computer Science 2025-02-05 Maximilian Reissmann , Yuan Fang , Andrew S. H. Ooi , Richard D. Sandberg

Recently, Cartesian Genetic Programming has been used to evolve developmental programs to guide the formation of artificial neural networks (ANNs). This approach has demonstrated success in enabling ANNs to perform multiple tasks while…

Neural and Evolutionary Computing · Computer Science 2024-07-16 Yintong Zhang , Jason A. Yoder

Protein engineers conventionally use tools such as Directed Evolution to find new proteins with better functionalities and traits. More recently, computational techniques and especially machine learning approaches have been recruited to…

Neural and Evolutionary Computing · Computer Science 2022-02-24 Iliya Miralavy , Alexander Bricco , Assaf Gilad , Wolfgang Banzhaf

Finding the optimal parameter setting (i.e. the optimal population size, the optimal mutation probability, the optimal evolutionary model etc) for an Evolutionary Algorithm (EA) is a difficult task. Instead of evolving only the parameters…

Neural and Evolutionary Computing · Computer Science 2021-09-29 Mihai Oltean , Crina Groşan

The main power of artificial intelligence is not in modeling what we already know, but in creating solutions that are new. Such solutions exist in extremely large, high-dimensional, and complex search spaces. Population-based search…

Neural and Evolutionary Computing · Computer Science 2020-02-25 Risto Miikkulainen

Evolutionary algorithms are wildly used in unmanned aerial vehicle path planning for their flexibility and effectiveness. Nevertheless, they are so sensitive to the change of environment that can't adapt to all scenarios. Due to this…

Neural and Evolutionary Computing · Computer Science 2022-04-08 Jiabin Lou , Rong Ding , Wenjun Wu

The main power of artificial intelligence is not in modeling what we already know, but in creating solutions that are new. Such solutions exist in extremely large, high-dimensional, and complex search spaces. Population-based search…

Neural and Evolutionary Computing · Computer Science 2021-02-16 Risto Miikkulainen

For billions of years, evolution has been the driving force behind the development of life, including humans. Evolution endowed humans with high intelligence, which allowed us to become one of the most successful species on the planet.…

Computers and Society · Computer Science 2023-07-21 Dan Hendrycks

The effective planning and allocation of resources in modern breeding programs is a complex task. Breeding program design and operational management have a major impact on the success of a breeding program and changing parameters such as…

Quantitative Methods · Quantitative Biology 2024-07-25 Azadeh Hassanpour , Johannes Geibel , Henner Simianer , Antje Rohde , Torsten Pook

This paper presents an evolutionary algorithm with a new goal-sequence domination scheme for better decision support in multi-objective optimization. The approach allows the inclusion of advanced hard/soft priority and constraint…

Artificial Intelligence · Computer Science 2011-06-02 E. F. Khor , T. H. Lee , R. Sathikannan , K. C. Tan

Death has long been overlooked in evolutionary algorithms. Recent research has shown that death (when applied properly) can benefit the overall fitness of a population and can outperform sub-sections of a population that are "immortal" when…

Neural and Evolutionary Computing · Computer Science 2021-09-29 Micah Burkhardt , Roman V. Yampolskiy

In this paper, we study the influence of the selective pressure on the performance of cellular genetic algorithms. Cellular genetic algorithms are genetic algorithms where the population is embedded on a toroidal grid. This structure makes…

Artificial Intelligence · Computer Science 2008-12-18 David Simoncini , Philippe Collard , Sébastien Verel , Manuel Clergue