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The reconstruction of cerebral cortex surfaces from brain MRI scans is instrumental for the analysis of brain morphology and the detection of cortical thinning in neurodegenerative diseases like Alzheimer's disease (AD). Moreover, for a…

Neurons and Cognition · Quantitative Biology 2022-10-05 Anne-Marie Rickmann , Fabian Bongratz , Sebastian Pölsterl , Ignacio Sarasua , Christian Wachinger

In this thesis, we present robust and fully-automated methods for the subdivision of the entire human cerebral cortex based on connectivity information. Our contributions are four-fold: First, we propose a clustering approach to delineate a…

Neurons and Cognition · Quantitative Biology 2018-02-21 Salim Arslan

Surface-based analysis of the cerebral cortex is ubiquitous in human neuroimaging with MRI. It is crucial for cortical registration, parcellation, and thickness estimation. Traditionally, these analyses require high-resolution, isotropic…

Image and Video Processing · Electrical Eng. & Systems 2024-09-09 Karthik Gopinath , Douglas N. Greve , Colin Magdamo , Steve Arnold , Sudeshna Das , Oula Puonti , Juan Eugenio Iglesias

Whole brain parcellation requires inferring hundreds of segmentation labels in large image volumes and thus presents significant practical challenges for deep learning approaches. We introduce label merge-and-split, a method that first…

Computer Vision and Pattern Recognition · Computer Science 2024-10-22 Aaron Kujawa , Reuben Dorent , Sebastien Ourselin , Tom Vercauteren

Sub-cortical brain structure segmentation in Magnetic Resonance Images (MRI) has attracted the interest of the research community for a long time because morphological changes in these structures are related to different neurodegenerative…

Computer Vision and Pattern Recognition · Computer Science 2018-11-15 Kaisar Kushibar , Sergi Valverde , Sandra Gonzalez-Villa , Jose Bernal , Mariano Cabezas , Arnau Oliver , Xavier Llado

Cortical surface parcellation is a fundamental task in both basic neuroscience research and clinical applications, enabling more accurate mapping of brain regions. Model-based and learning-based approaches for automated parcellation…

Neurons and Cognition · Quantitative Biology 2025-12-30 Jian Li , Karthik Gopinath , Brian L. Edlow , Adrian V. Dalca , Bruce Fischl

Whole brain segmentation on a structural magnetic resonance imaging (MRI) is essential in non-invasive investigation for neuroanatomy. Historically, multi-atlas segmentation (MAS) has been regarded as the de facto standard method for whole…

Computer Vision and Pattern Recognition · Computer Science 2018-06-06 Yuankai Huo , Zhoubing Xu , Katherine Aboud , Prasanna Parvathaneni , Shunxing Bao , Camilo Bermudez , Susan M. Resnick , Laurie E. Cutting , Bennett A. Landman

Surface analysis of the cortex is ubiquitous in human neuroimaging with MRI, e.g., for cortical registration, parcellation, or thickness estimation. The convoluted cortical geometry requires isotropic scans (e.g., 1mm MPRAGEs) and good…

Image and Video Processing · Electrical Eng. & Systems 2023-05-04 Karthik Gopinath , Douglas N. Greve , Sudeshna Das , Steve Arnold , Colin Magdamo , Juan Eugenio Iglesias

Segmentation of brain magnetic resonance images (MRI) is crucial for the analysis of the human brain and diagnosis of various brain disorders. The drawbacks of time-consuming and error-prone manual delineation procedures are aimed to be…

Computer Vision and Pattern Recognition · Computer Science 2022-05-20 Can Taylan Sari , Sila Kurugol , Onur Afacan , Simon K. Warfield

We present a hybrid method that performs the complete parcellation of the cerebral cortex of an individual, based on the connectivity information of the white matter fibers from a whole-brain tractography dataset. The method consists of…

Neurons and Cognition · Quantitative Biology 2020-02-24 Narciso López-López , Andrea Vázquez , Cyril Poupon , Jean-François Mangin , Pamela Guevara

Whole brain segmentation on structural magnetic resonance imaging (MRI) is essential for understanding neuroanatomical-functional relationships. Traditionally, multi-atlas segmentation has been regarded as the standard method for whole…

Computer Vision and Pattern Recognition · Computer Science 2019-01-09 Yunxi Xiong , Yuankai Huo , Jiachen Wang , L. Taylor Davis , Maureen McHugo , Bennett A. Landman

Whole-brain parcellation from MRI is a critical yet challenging task due to the complexity of subdividing the brain into numerous small, irregular shaped regions. Traditionally, template-registration methods were used, but recent advances…

Computer Vision and Pattern Recognition · Computer Science 2026-01-15 Yucheng Li , Xiaofan Wang , Junyi Wang , Yijie Li , Xi Zhu , Mubai Du , Dian Sheng , Wei Zhang , Fan Zhang

Segmentation of brain structures in a large dataset of magnetic resonance images (MRI) necessitates automatic segmentation instead of manual tracing. Automatic segmentation methods provide a much-needed alternative to manual segmentation…

Image and Video Processing · Electrical Eng. & Systems 2020-08-11 Mohammad-Parsa Hosseini , Esmaeil Davoodi , Evangelia Bouzos , Kost Elisevich , Hamid Soltanian-Zadeh

Many functional and structural neuroimaging studies call for accurate morphometric segmentation of different brain structures starting from image intensity values of MRI scans. Current automatic (multi-) atlas-based segmentation strategies…

Image and Video Processing · Electrical Eng. & Systems 2019-09-27 Dennis Bontempi , Sergio Benini , Alberto Signoroni , Michele Svanera , Lars Muckli

Whole-brain surface extraction is an essential topic in medical imaging systems as it provides neurosurgeons with a broader view of surgical planning and abnormality detection. To solve the problem confronted in current deep learning skull…

Computer Vision and Pattern Recognition · Computer Science 2021-04-12 Heng Fang , Xi Yang , Taichi Kin , Takeo Igarashi

Here we present a method for the simultaneous segmentation of white matter lesions and normal-appearing neuroanatomical structures from multi-contrast brain MRI scans of multiple sclerosis patients. The method integrates a novel model for…

Image and Video Processing · Electrical Eng. & Systems 2020-11-26 Stefano Cerri , Oula Puonti , Dominik S. Meier , Jens Wuerfel , Mark Mühlau , Hartwig R. Siebner , Koen Van Leemput

Identification of vessel structures of different sizes in biomedical images is crucial in the diagnosis of many neurodegenerative diseases. However, the sparsity of good-quality annotations of such images makes the task of vessel…

Traditional neuroimage analysis pipelines involve computationally intensive, time-consuming optimization steps, and thus, do not scale well to large cohort studies with thousands or tens of thousands of individuals. In this work we propose…

Image and Video Processing · Electrical Eng. & Systems 2020-06-11 Leonie Henschel , Sailesh Conjeti , Santiago Estrada , Kersten Diers , Bruce Fischl , Martin Reuter

Parcellation of human cerebellar pathways is essential for advancing our understanding of the human brain. Existing diffusion MRI tractography parcellation methods have been successful in defining major cerebellar fibre tracts, while…

Although deep learning (DL) shows powerful potential in cell segmentation tasks, it suffers from poor generalization as DL-based methods originally simplified cell segmentation in detecting cell membrane boundary, lacking prominent cellular…

Image and Video Processing · Electrical Eng. & Systems 2023-03-22 Fang Hu , Xuexue Sun , Ke Qing , Fenxi Xiao , Zhi Wang , Xiaolu Fan
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