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Diffusion Magnetic Resonance Imaging (MRI) exploits the anisotropic diffusion of water molecules in the brain to enable the estimation of the brain's anatomical fiber tracts at a relatively high resolution. In particular, tractographic…

Computational Engineering, Finance, and Science · Computer Science 2016-09-14 Yu Jin , Joseph F. JaJa , Rong Chen , Edward H. Herskovits

Functional networks characterize the coordinated neural activity observed by functional neuroimaging. The prevalence of different networks during resting state periods provide useful features for predicting the trajectory of…

Signal Processing · Electrical Eng. & Systems 2021-11-16 Hassan Baker , Austin J. Brockmeier

High-throughput methods for yielding the set of connections in a neural system, the connectome, are now being developed. This tutorial describes ways to analyze the topological and spatial organization of the connectome at the macroscopic…

Neurons and Cognition · Quantitative Biology 2011-12-23 Marcus Kaiser

The question of controllability of natural and man-made network systems has recently received considerable attention. In the context of the human brain, the study of controllability may not only shed light into the organization and function…

Optimization and Control · Mathematics 2021-02-10 Tommaso Menara , Shi Gu , Danielle S. Bassett , Fabio Pasqualetti

Self-organization and pattern formation in network-organized systems emerges from the collective activation and interaction of many interconnected units. A striking feature of these non-equilibrium structures is that they are often…

Physics and Society · Physics 2016-02-23 Christos Nicolaides , Ruben Juanes , Luis Cueto-Felgueroso

In order to understand the complex cognitive functions of the human brain, it is essential to study the structural connectome, i.e., the wiring of different brain regions to each other through axonal pathways. However, the high degree of…

Neurons and Cognition · Quantitative Biology 2021-01-25 Anand Pathak , Shakti N. Menon , Sitabhra Sinha

Recurrent neural networks (RNNs) trained on low-dimensional tasks have been widely used to model functional biological networks. However, the solutions found by learning and the effect of initial connectivity are not well understood. Here,…

Neurons and Cognition · Quantitative Biology 2021-05-17 Friedrich Schuessler , Francesca Mastrogiuseppe , Alexis Dubreuil , Srdjan Ostojic , Omri Barak

Understanding the human brain remains the Holy Grail in biomedical science, and arguably in all of the sciences. Our brains represent the most complex systems in the world (and some contend the universe) comprising nearly one hundred…

Quantitative Methods · Quantitative Biology 2016-02-03 Sean L. Simpson , Paul J. Laurienti

A computer model is described which is used to assess the dynamical complexity of a class of networks of spiking neurons with small-world properties. Networks are constructed by forming an initially segregated set of highly intra-connected…

Biological Physics · Physics 2009-11-13 Murray Shanahan

Signal propagation along the structural connectome of the brain induces changes in the patterns of activity. These activity patterns define global brain states and contain information in accordance with their expected probability of…

Neurons and Cognition · Quantitative Biology 2023-03-16 Leon Weninger , Pragya Srivastava , Dale Zhou , Jason Z. Kim , Eli J. Cornblath , Maxwell A. Bertolero , Ute Habel , Dorit Merhof , Dani S. Bassett

The connectivity of individual neurons of large neural networks determine both the steady state activity of the network and its answer to external stimulus. Highly diluted random networks have zero activity. We show that increasing the…

Condensed Matter · Physics 2008-02-03 Albert-László Barabási

Typical brain networks consist of many peripheral regions and a few highly central ones, i.e. hubs, playing key functional roles in cerebral inter-regional interactions. Studies have shown that networks, obtained from the analysis of…

Neurons and Cognition · Quantitative Biology 2016-07-19 Manlio De Domenico , Shuntaro Sasai , Alex Arenas

Functional connectivity (FC) refers to the investigation of interactions between brain regions to understand integration of neural activity in several regions. FC is often estimated using functional magnetic resonance images (fMRI). There…

Applications · Statistics 2023-01-24 Nathan Tung , Jerome Sanes , Eli Upfal , Ani Eloyan

The human brain has a complex, intricate functional architecture. While many studies primarily emphasize pairwise interactions, delving into high-order associations is crucial for a comprehensive understanding of how functional brain…

Neurons and Cognition · Quantitative Biology 2023-10-30 Qiang Li , Vince D. Calhoun , Adithya Ram Ballem , Shujian Yu , Jesus Malo , Armin Iraji

The idea to estimate the statistical interdependence among (interacting) brain regions has motivated numerous researchers to investigate how the resulting connectivity patterns and networks may organize themselves under any conceivable…

Neurons and Cognition · Quantitative Biology 2021-02-03 Matteo Fraschini , Simone Maurizio La Cava , Luca Didaci , Luigi Barberini

Neural networks are high-dimensional nonlinear dynamical systems that process information through the coordinated activity of many connected units. Understanding how biological and machine-learning networks function and learn requires…

Neurons and Cognition · Quantitative Biology 2023-09-13 David G. Clark , L. F. Abbott , Ashok Litwin-Kumar

A theoretical framework describing the set of interactions between neurons in the brain, or functional connectivity, should include dynamical functions representing the propagation of signal from one neuron to another. Green's functions and…

Neurons and Cognition · Quantitative Biology 2021-03-24 Francesco Randi , Andrew M. Leifer

Functional magnetic resonance imaging (fMRI) data is characterized by its complexity and high--dimensionality, encompassing signals from various regions of interests (ROIs) that exhibit intricate correlations. Analyzing fMRI data directly…

Applications · Statistics 2024-01-18 Yeseul Jeon , Jeong-Jae Kim , SuMin Yu , Junggu Choi , Sanghoon Han

Many recent efforts in computational modeling of macro-scale brain dynamics have begun to take a data-driven approach by incorporating structural and/or functional information derived from subject data. Here, we discuss recent work using…

Neurons and Cognition · Quantitative Biology 2018-11-15 Kanika Bansal , Johan Nakuci , Sarah Feldt Muldoon

It has been said that complexity lies between order and disorder. In the case of brain activity, and physiology in general, complexity issues are being considered with increased emphasis. We sought to identify features of brain organization…

Neurons and Cognition · Quantitative Biology 2017-01-11 R. Guevara Erra , D. M. Mateos , R. Wennberg , J. L. Perez Velazquez