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Randomly connected neural networks have long served as a theoretical tool for studying collective dynamics in neural populations, yet quantitative comparisons to experiments remain limited. Recent technological advances have made it…

Neurons and Cognition · Quantitative Biology 2026-05-27 Zehui Zhao , Michael J Pasek , Ilya M Nemenman

Many networks in nature and applications have an approximate low-rank structure in the sense that their connectivity structure is dominated by a few dimensions. It is natural to expect that dynamics on such networks would also be…

Dynamical Systems · Mathematics 2026-05-29 Yue Wan , Robert Rosenbaum

Using a generalized random recurrent neural network model, and by extending our recently developed mean-field approach [J. Aljadeff, M. Stern, T. Sharpee, Phys. Rev. Lett. 114, 088101 (2015)], we study the relationship between the network…

Disordered Systems and Neural Networks · Physics 2016-02-09 Johnatan Aljadeff , David Renfrew , Marina Vegué , Tatyana O. Sharpee

An emerging paradigm proposes that neural computations can be understood at the level of dynamical systems that govern low-dimensional trajectories of collective neural activity. How the connectivity structure of a network determines the…

Neurons and Cognition · Quantitative Biology 2021-05-28 Manuel Beiran , Alexis Dubreuil , Adrian Valente , Francesca Mastrogiuseppe , Srdjan Ostojic

Recurrent neural networks (RNNs) trained on low-dimensional tasks have been widely used to model functional biological networks. However, the solutions found by learning and the effect of initial connectivity are not well understood. Here,…

Neurons and Cognition · Quantitative Biology 2021-05-17 Friedrich Schuessler , Francesca Mastrogiuseppe , Alexis Dubreuil , Srdjan Ostojic , Omri Barak

Neural circuits comprise multiple interconnected regions, each with complex dynamics. The interplay between local and global activity is thought to underlie computational flexibility, yet the structure of multiregion neural activity and its…

Neurons and Cognition · Quantitative Biology 2025-01-09 David G. Clark , Manuel Beiran

Connectivity structure shapes neural computation, but inferring this structure from population recordings is degenerate: multiple connectivity structures can generate identical dynamics. Recent work uses low-rank recurrent neural networks…

Neurons and Cognition · Quantitative Biology 2026-03-30 Timothy Doyeon Kim , Ulises Pereira-Obilinovic , Yiliu Wang , Eric Shea-Brown , Uygar Sümbül

Cortical neurons whose activity is recorded in behavioral experiments has been classified into several types such as stimulus-related neurons, delay-period neurons, and reward-related neurons. Moreover, the population activity of neurons…

Neurons and Cognition · Quantitative Biology 2018-11-27 Takuma Tanaka

A given neural network in the brain is involved in many different tasks. This implies that, when considering a specific task, the network's connectivity contains a component which is related to the task and another component which can be…

Neurons and Cognition · Quantitative Biology 2021-03-17 Friedrich Schuessler , Alexis Dubreuil , Francesca Mastrogiuseppe , Srdjan Ostojic , Omri Barak

We explore the interplay between the topological relevance of a neuron and its dynamical traces in experimental cultured neuronal networks. We monitor the growth and development of these networks to characterise the evolution of their…

Adaptation and Self-Organizing Systems · Physics 2023-07-14 A. Tlaie , L. M. Ballesteros-Esteban , I. Leyva , I. Sendina-Nadal

A powerful approach for understanding neural population dynamics is to extract low-dimensional trajectories from population recordings using dimensionality reduction methods. Current approaches for dimensionality reduction on neural data…

Machine Learning · Statistics 2017-11-07 Marcel Nonnenmacher , Srinivas C. Turaga , Jakob H. Macke

Neural population activity in sensory cortex is organized on low-dimensional manifolds, but why such manifolds arise and what determines their geometry remain unclear. We model cortical populations as recurrent circuits driven by…

Neurons and Cognition · Quantitative Biology 2026-04-14 Vikas N. O'Reilly-Shah , Alessandro Maria Selvitella

Empirical estimates of the dimensionality of neural population activity are often much lower than the population size. Similar phenomena are also observed in trained and designed neural network models. These experimental and computational…

Neurons and Cognition · Quantitative Biology 2020-02-11 Omri Barak , Sandro Romani

Studies of the dynamics of nonlinear recurrent neural networks often assume independent and identically distributed couplings, but large-scale connectomics data indicate that biological neural circuits exhibit markedly different…

Neurons and Cognition · Quantitative Biology 2025-10-28 David G. Clark , Owen Marschall , Alexander van Meegen , Ashok Litwin-Kumar

Neuronal networks constitute a special class of dynamical systems, as they are formed by individual geometrical components, namely the neurons. In the existing literature, relatively little attention has been given to the influence of…

Neurons and Cognition · Quantitative Biology 2015-05-13 Sebastian Ahnert , Luciano da Fontoura Costa

Neural circuits exhibit structured connectivity, including an overrepresentation of reciprocal connections between neuron pairs. Despite important advances, a full understanding of how such partial symmetry in connectivity shapes neural…

Dimensionality reduction, a form of compression, can simplify representations of information to increase efficiency and reveal general patterns. Yet, this simplification also forfeits information, thereby reducing representational capacity.…

Complex systems are high-dimensional nonlinear dynamical systems with intricate interactions among their constituents. To make interpretable predictions about their large-scale behavior, it is typically assumed, without a clear statement,…

Adaptation and Self-Organizing Systems · Physics 2024-11-07 Vincent Thibeault , Antoine Allard , Patrick Desrosiers

Networks are ubiquitous throughout science and engineering. A number of methods, including some from our own group, have explored how one goes about computing or predicting the dynamics of networks given information about internal models of…

Molecular Networks · Quantitative Biology 2017-11-06 Gabriel A. Silva

A large body of work has suggested that neural populations exhibit low-dimensional dynamics during behavior. However, there are a variety of different approaches for modeling low-dimensional neural population activity. One approach involves…

Neurons and Cognition · Quantitative Biology 2021-10-20 Adrian Valente , Srdjan Ostojic , Jonathan Pillow
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