Related papers: Stress, Depression and Neuroplasticity
A large repertoire of spatiotemporal activity patterns in the brain is the basis for adaptive behaviour. Understanding the mechanism by which the brain's hundred billion neurons and hundred trillion synapses manage to produce such a range…
The dynamics of local cortical networks are irregular, but correlated. Dynamic excitatory--inhibitory balance is a plausible mechanism that generates such irregular activity, but it remains unclear how balance is achieved and maintained in…
This paper introduces a new modeling perspective in the public mental health domain to provide a robust interpretation of the relations between anxiety and depression, and the demographic and temporal factors. This perspective particularly…
In neuroscience, synaptic plasticity refers to the set of mechanisms driving the dynamics of neuronal connections, called synapses and represented by a scalar value, the synaptic weight. A Spike-Timing Dependent Plasticity (STDP) rule is a…
Continuous adaptation allows survival in an ever-changing world. Adjustments in the synaptic coupling strength between neurons are essential for this capability, setting us apart from simpler, hard-wired organisms. How these changes can be…
Predicting how the brain can be driven to specific states by means of internal or external control requires a fundamental understanding of the relationship between neural connectivity and activity. Network control theory is a powerful tool…
The characterization of plasticity, robustness, and evolvability, an important issue in biology, is studied in terms of phenotypic fluctuations. By numerically evolving gene regulatory networks, the proportionality between the phenotypic…
Depression has been associated with impaired neural processing of reward and punishment. However, to date, little is known regarding the relationship between depression and intertemporal choice for gain and loss. We compared impulsivity and…
Studying psychiatric illness has often been limited by difficulties in connecting symptoms and behavior to neurobiology. Computational psychiatry approaches promise to bridge this gap by providing formal accounts of the latent information…
While probabilistic models describe the dependence structure between observed variables, causal models go one step further: they predict, for example, how cognitive functions are affected by external interventions that perturb neuronal…
The behavior of the network and its stability are governed by both dynamics of individual nodes as well as their topological interconnections. Attention mechanism as an integral part of neural network models was initially designed for…
Chronic pain is a widespread and debilitating condition that affects millions of individuals worldwide. Recent research has unveiled a connection between chronic pain and epigenetic processes, shedding light on the complex interplay between…
The human brain is composed of distinct regions that are each associated with particular functions and distinct propensities for the control of neural dynamics. However, the relation between these functions and control profiles is poorly…
Dynamical wiring and rewiring in neural networks are carried out by activity-dependent growth and retraction of axons and dendrites, guided by gudance molecules, released by target cells. Experience-dependent structural changes in cortical…
Previous research has shown a clear relationship between sleep and memory, examining the impact of sleep deprivation on key cognitive processes over very short durations or in special populations. Here, we show, in a longitudinal 16 week…
Necking instabilities, in which tensile (extensional) deformation localizes into a small spatial region, are generic failure modes in elasto-viscoplastic materials. Materials in this very broad class --- including amorphous, crystalline,…
Elasticity theory calculations predict the number N of depressions that appear at the surface of a spherical thin shell submitted to an external isotropic pressure. In a model that mainly considers curvature deformations, we show that N…
It is obvious that emotions are causal variables of motivation, as they elicit states, forces and energies that trigger and guide labor behavior. Thus, a motivational tension that is not informed by needs alone, but also by emotions,…
This essay is presented with two principal objectives in mind: first, to document the prevalence of fractals at all levels of the nervous system, giving credence to the notion of their functional relevance; and second, to draw attention to…
Neuropeptides, members of a large and evolutionarily ancient family of proteinaceous cell-cell signaling molecules, are widely recognized as extremely potent regulators of brain function and behavior. At the cellular level, neuropeptides…