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Integrating multi-omics datasets through data-driven analysis offers a comprehensive understanding of the complex biological processes underlying various diseases, particularly cancer. Graph Neural Networks (GNNs) have recently demonstrated…

Machine Learning · Computer Science 2025-08-11 Jielong Lu , Zhihao Wu , Jiajun Yu , Jiajun Bu , Haishuai Wang

Statistical approaches that successfully combine multiple datasets are more powerful, efficient, and scientifically informative than separate analyses. To address variation architectures correctly and comprehensively for high-dimensional…

Methodology · Statistics 2023-09-01 Jiuzhou Wang , Eric F. Lock

International initiatives such as METABRIC (Molecular Taxonomy of Breast Cancer International Consortium) have collected several multigenomic and clinical data sets to identify the undergoing molecular processes taking place throughout the…

Machine Learning · Computer Science 2022-11-29 Teodora Reu

Tucker decomposition is a powerful tensor model to handle multi-aspect data. It demonstrates the low-rank property by decomposing the grid-structured data as interactions between a core tensor and a set of object representations (factors).…

Machine Learning · Computer Science 2024-03-20 Shikai Fang , Xin Yu , Zheng Wang , Shibo Li , Mike Kirby , Shandian Zhe

Large CNNs have delivered impressive performance in various computer vision applications. But the storage and computation requirements make it problematic for deploying these models on mobile devices. Recently, tensor decompositions have…

Machine Learning · Computer Science 2016-02-16 Cheng Tai , Tong Xiao , Yi Zhang , Xiaogang Wang , Weinan E

One of the notable fields in studying the genetics of cancer is disease gene identification which affects disease treatment and drug discovery. Many researches have been done in this field. Genome-wide association studies (GWAS) are one of…

Computational Engineering, Finance, and Science · Computer Science 2016-04-27 Zahra Razaghi-Moghadama , Razieh Abdollahia , Sama Goliaeib , Morteza Ebrahimia

Computed tomography (CT) is a widely used non-invasive diagnostic method in various fields, and recent advances in deep learning have led to significant progress in CT image reconstruction. However, the lack of large-scale, open-access…

Image and Video Processing · Electrical Eng. & Systems 2024-12-12 Maximilian B. Kiss , Ander Biguri , Zakhar Shumaylov , Ferdia Sherry , K. Joost Batenburg , Carola-Bibiane Schönlieb , Felix Lucka

State-of-the-art federated learning methods can perform far worse than their centralized counterparts when clients have dissimilar data distributions. For neural networks, even when centralized SGD easily finds a solution that is…

Machine Learning · Computer Science 2022-10-06 Yaodong Yu , Alexander Wei , Sai Praneeth Karimireddy , Yi Ma , Michael I. Jordan

Early detection of cancer plays a key role in improving survival rates, but identifying reliable biomarkers from RNA-seq data is still a major challenge. The data are high-dimensional, and conventional statistical methods often fail to…

Machine Learning · Computer Science 2025-12-09 Shreyas Shende , Varsha Narayanan , Vishal Fenn , Yiran Huang , Dincer Goksuluk , Gaurav Choudhary , Melih Agraz , Mengjia Xu

Dual-energy computed tomography (DECT) is an advanced CT scanning technique enabling material characterization not possible with conventional CT scans. It allows the reconstruction of energy decay curves at each 3D image voxel, representing…

Image and Video Processing · Electrical Eng. & Systems 2022-02-01 Segolene Brivet , Faicel Chamroukhi , Mark Coates , Reza Forghani , Peter Savadjiev

We consider the problem of low-rank approximation of massive dense non-negative tensor data, for example to discover latent patterns in video and imaging applications. As the size of data sets grows, single workstations are hitting…

Numerical Analysis · Mathematics 2019-09-04 Srinivas Eswar , Koby Hayashi , Grey Ballard , Ramakrishnan Kannan , Michael A. Matheson , Haesun Park

Motivation. Understanding the pan-cancer mutational landscape offers critical insights into the molecular mechanisms underlying tumorigenesis. While patient-level machine learning techniques have been widely employed to identify tumor…

Machine Learning · Computer Science 2025-08-29 Yifan Dou , Adam Khadre , Ruben C Petreaca , Golrokh Mirzaei

Deep neural networks (DNNs) have delivered a remarkable performance in many tasks of computer vision. However, over-parameterized representations of popular architectures dramatically increase their computational complexity and storage…

Computer Vision and Pattern Recognition · Computer Science 2022-05-31 Chang Nie , Huan Wang , Lu Zhao

A central goal in cancer genomics is to identify the somatic alterations that underpin tumor initiation and progression. This task is challenging as the mutational profiles of cancer genomes exhibit vast heterogeneity, with many alterations…

Genomics · Quantitative Biology 2017-04-28 Borislav H. Hristov , Mona Singh

How can we expand the tensor decomposition to reveal a hierarchical structure of the multi-modal data in a self-adaptive way? Current tensor decomposition provides only a single layer of clusters. We argue that with the abundance of…

Information Retrieval · Computer Science 2020-11-17 Risul Islam , Md Omar Faruk Rokon , Evangelos E. Papalexakis , Michalis Faloutsos

Tensor-valued data arise naturally in neuroimaging, genomics, climate science, and spatiotemporal networks, where multilinear dependencies across modes carry information that is destroyed under vectorization. Existing approaches either…

Machine Learning · Statistics 2026-05-20 Elynn Chen , Jiayu Li , Zheshi Zheng , Jian Pei

Tensor network (TN) representation is a powerful technique for computer vision and machine learning. TN structure search (TN-SS) aims to search for a customized structure to achieve a compact representation, which is a challenging NP-hard…

Machine Learning · Computer Science 2024-04-15 Yu-Bang Zheng , Xi-Le Zhao , Junhua Zeng , Chao Li , Qibin Zhao , Heng-Chao Li , Ting-Zhu Huang

Motivation: Detecting local correlations in expression between neighbor genes along the genome has proved to be an effective strategy to identify possible causes of transcriptional deregulation in cancer. It has been successfully used to…

Recent analysis identified distinct genomic subtypes of lower-grade glioma tumors which are associated with shape features. In this study, we propose a fully automatic way to quantify tumor imaging characteristics using deep learning-based…

Image and Video Processing · Electrical Eng. & Systems 2019-06-11 Mateusz Buda , Ashirbani Saha , Maciej A Mazurowski

The research on developing CNN-based fully-automated Brain-Tumor-Segmentation systems has been progressed rapidly. For the systems to be applicable in practice, a good The research on developing CNN-based fully-automated…

Image and Video Processing · Electrical Eng. & Systems 2022-05-04 Juncheng Tong , Chunyan Wang