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In cancer research, profiling studies have been extensively conducted, searching for genes/SNPs associated with prognosis. Cancer is a heterogeneous disease. Examining similarity and difference in the genetic basis of multiple subtypes of…

Methodology · Statistics 2013-04-18 Jin Liu , Jian Huang , Yawei Zhang , Qing Lan , Nathaniel Rothman , Tongzhang Zheng , Shuangge Ma

Tumor volume segmentation on MRI is a challenging and time-consuming process that is performed manually in typical clinical settings. This work presents an approach to automated delineation of head and neck tumors on MRI scans, developed in…

Image and Video Processing · Electrical Eng. & Systems 2025-01-10 Andrei Iantsen

High-Order, High-Dimension, and Sparse Tensor (HOHDST) data originates from real industrial applications, i.e., social networks, recommender systems, bio-information, and traffic information. Sparse Tensor Decomposition (STD) can project…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-04-15 Zixuan Li

Automated breast tumor segmentation on the basis of dynamic contrast-enhancement magnetic resonance imaging (DCE-MRI) has shown great promise in clinical practice, particularly for identifying the presence of breast disease. However,…

Image and Video Processing · Electrical Eng. & Systems 2024-08-13 Lei Zhou , Yuzhong Zhang , Jiadong Zhang , Xuejun Qian , Chen Gong , Kun Sun , Zhongxiang Ding , Xing Wang , Zhenhui Li , Zaiyi Liu , Dinggang Shen

Network data are commonly collected in a variety of applications, representing either directly measured or statistically inferred connections between features of interest. In an increasing number of domains, these networks are collected…

Machine Learning · Statistics 2022-09-05 Michael Weylandt , George Michailidis

Spectral Photon-Counting Computed Tomography (SPCCT) is a promising technology that has shown a number of advantages over conventional X-ray Computed Tomography (CT) in the form of material separation, artefact removal and enhanced image…

Image and Video Processing · Electrical Eng. & Systems 2020-03-10 Dimitris Kamilis , Mario Blatter , Nick Polydorides

Network-based analyses of high-throughput genomics data provide a holistic, systems-level understanding of various biological mechanisms for a common population. However, when estimating multiple networks across heterogeneous…

Accurate breast tumor segmentation in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is important for downstream tasks such as pathological complete response (pCR) assessment. In this work, we address both segmentation and…

Image and Video Processing · Electrical Eng. & Systems 2025-10-10 Toufiq Musah

We analyze large, multi-dimensional, sparse counting data sets, finding unsupervised groups to provide unique insights into genetic data. We create gene and biological pathway groups based on patients' variants to find common risk factors…

Machine Learning · Computer Science 2025-09-01 Adam Sandler , Diego Klabjan , Yuan Luo

Spectral clustering (SC) and graph-based semi-supervised learning (SSL) algorithms are sensitive to how graphs are constructed from data. In particular if the data has proximal and unbalanced clusters these algorithms can lead to poor…

Machine Learning · Statistics 2013-02-22 Jing Qian , Venkatesh Saligrama

High-dimensional tensors or multi-way data are becoming prevalent in areas such as biomedical imaging, chemometrics, networking and bibliometrics. Traditional approaches to finding lower dimensional representations of tensor data include…

Machine Learning · Statistics 2012-02-14 Genevera I. Allen

Recent tumor genome sequencing confirmed that one tumor often consists of multiple cell subpopulations (clones) which bear different, but related, genetic profiles such as mutation and copy number variation profiles. Thus far, one tumor has…

Molecular Networks · Quantitative Biology 2014-09-09 Edwin Wang , Jinfeng Zou , Naif Zaman , Lenore K. Beitel , Mark Trifiro , Miltiadis Paliouras

Tucker tensor decomposition offers a more effective representation for multiway data compared to the widely used PARAFAC model. However, its flexibility brings the challenge of selecting the appropriate latent multi-rank. To overcome the…

Methodology · Statistics 2025-05-19 Federica Stolf , Antonio Canale

In the realm of tensor optimization, the low-rank Tucker decomposition is crucial for reducing the number of parameters and for saving storage. We explore the geometry of Tucker tensor varieties -- the set of tensors with bounded Tucker…

Optimization and Control · Mathematics 2024-07-16 Bin Gao , Renfeng Peng , Ya-xiang Yuan

Extracting associations that recur across multiple studies while controlling the false discovery rate is a fundamental challenge. Here, we consider an extension of Efron's single-study two-groups model to allow joint analysis of multiple…

Methodology · Statistics 2019-01-14 David Amar , Ron Shamir , Daniel Yekutieli

The increased availability of the multi-view data (data on the same samples from multiple sources) has led to strong interest in models based on low-rank matrix factorizations. These models represent each data view via shared and individual…

Machine Learning · Statistics 2021-04-01 Irina Gaynanova , Gen Li

Decompositions of tensors into factor matrices, which interact through a core tensor, have found numerous applications in signal processing and machine learning. A more general tensor model which represents data as an ordered network of…

Numerical Analysis · Computer Science 2016-09-30 Anh-Huy Phan , Andrzej Cichocki , Andre Uschmajew , Petr Tichavsky , George Luta , Danilo Mandic

Spiking Neural Networks (SNNs) have gained significant attention as a potentially energy-efficient alternative for standard neural networks with their sparse binary activation. However, SNNs suffer from memory and computation overhead due…

Neural and Evolutionary Computing · Computer Science 2026-03-09 Donghyun Lee , Ruokai Yin , Youngeun Kim , Abhishek Moitra , Yuhang Li , Priyadarshini Panda

To efficiently express tensor data using the Tucker format, a critical task is to minimize the multilinear rank such that the model would not be over-flexible and lead to overfitting. Due to the lack of rank minimization tools in tensor,…

Signal Processing · Electrical Eng. & Systems 2024-09-11 Xueke Tong , Hancheng Zhu , Lei Cheng , Yik-Chung Wu

Most currently used tensor regression models for high-dimensional data are based on Tucker decomposition, which has good properties but loses its efficiency in compressing tensors very quickly as the order of tensors increases, say greater…

Methodology · Statistics 2024-03-20 Yuefeng Si , Yingying Zhang , Yuxi Cai , Chunling Liu , Guodong Li
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