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Cytometry experiments yield high-dimensional point cloud data that is difficult to interpret manually. Boolean gating techniques coupled with comparisons of relative abundances of cellular subsets is the current standard for cytometry data…

Quantitative Methods · Quantitative Biology 2022-05-04 Soham Mukherjee , Darren Wethington , Tamal K. Dey , Jayajit Das

Fluorescent Timer proteins, which spontaneously change their emission spectra over time, are valuable tools for analyzing temporal changes in cellular activities at the single-cell level. Traditional analysis of Fluorescent Timer data has…

Quantitative Methods · Quantitative Biology 2024-11-15 Masahiro Ono

Detection and differentiation of circulating tumor cells (CTCs) and non-CTCs in blood draws of cancer patients pose multiple challenges. While the gold standard relies on tedious manual evaluation of an automatically generated selection of…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Hümeyra Husseini-Wüsthoff , Sabine Riethdorf , Andreas Schneeweiss , Andreas Trumpp , Klaus Pantel , Harriet Wikman , Maximilian Nielsen , René Werner

Plant life plays a critical role in the ecosystem. However, it is difficult for humans to perceive plants' reactions because the biopotential and biochemical responses are invisible to humans. Guttation droplets contain various chemicals…

Human-Computer Interaction · Computer Science 2023-02-13 Qiuyu Lu , Lydia Yang , Aditi Maheshwari , Hengrong Ni , Tianyu Yu , Jianzhe Gu , Advait Wadhwani , Andreea Danielescu , Lining Yao

Process mining in healthcare presents a range of challenges when working with different types of data within the healthcare domain. There is high diversity considering the variety of data collected from healthcare processes: operational…

We propose a new method for automatically detecting monotonic input-output relationships from data using Gaussian Process (GP) models with virtual derivative observations. Our results on synthetic and real datasets show that the proposed…

Methodology · Statistics 2016-10-19 Eero Siivola , Juho Piironen , Aki Vehtari

This paper explores how far the scientific discovery process can be automated. Using the identification of causally significant flow structures in two-dimensional turbulence as an example, it probes how far the usual procedure of planning…

Fluid Dynamics · Physics 2020-12-02 Javier Jimenez

We propose a new framework that focuses on on-site entities in the digital twin, a pairing of the real world and digital space. Characteristics include active sensing to generate event logs, spatial and temporal partitioning of complex…

Applications · Statistics 2025-06-09 Shintaro Yoshizawa , Takayuki Kanai , Masahiro Kagi

Label-free approaches are attractive in cytological imaging due to their flexibility and cost efficiency. They are supported by machine learning methods, which, despite the lack of labeling and the associated lower contrast, can classify…

Computer Vision and Pattern Recognition · Computer Science 2023-11-27 Stefan Röhrl , Johannes Groll , Manuel Lengl , Simon Schumann , Christian Klenk , Dominik Heim , Martin Knopp , Oliver Hayden , Klaus Diepold

Factor analysis or sometimes referred to as variable analysis has been extensively used in classification problems for identifying specific factors that are significant to particular classes. This type of analysis has been widely used in…

Machine Learning · Computer Science 2019-05-01 Nagdev Amruthnath , Tarun Gupta

Optical coherence tomography angiography (OCTA) is an imaging technique that allows for non-invasive investigation of the microvasculature in the retina. OCTA uses laser light reflectance to measure moving blood cells. Hereby, it visualizes…

Tissues and Organs · Quantitative Biology 2020-02-11 Astrid M. E. Engberg , Vedrana A. Dahl , Anders B. Dahl

Bayesian filtering is a general framework for recursively estimating the state of a dynamical system. Classical solutions such that Kalman filter and Particle filter are introduced in this report. Gaussian processes have been introduced as…

Information Theory · Computer Science 2010-11-04 Mr. Chong Han , Dr. Ido Nevat , Dr. Gareth Peters , Prof. Jinhong Yuan

Numerical simulations of plasma flows are crucial for advancing our understanding of microscopic processes that drive the global plasma dynamics in fusion devices, space, and astrophysical systems. Identifying and classifying particle…

Computational Physics · Physics 2020-10-13 Stefano Markidis , Ivy Peng , Artur Podobas , Itthinat Jongsuebchoke , Gabriel Bengtsson , Pawel Herman

Hamiltonian Flow Monte Carlo(HFMC) methods have been implemented in engineering, biology and chemistry. HFMC makes large gradient based steps to rapidly explore the state space. The application of the Hamiltonian dynamics allows to estimate…

Computation · Statistics 2017-09-06 Raphael Douady , Shohruh Miryusupov

In the effort to aid cytologic diagnostics by establishing automatic single cell screening using high throughput digital holographic microscopy for clinical studies thousands of images and millions of cells are captured. The bottleneck lies…

Image and Video Processing · Electrical Eng. & Systems 2024-10-28 Julia Sistermanns , Ellen Emken , Gregor Weirich , Oliver Hayden , Wolfgang Utschick

Blood system functions are very diverse and important for most processes in human organism. One of its primary functions is matter transport among different parts of the organism including tissue supplying with oxygen, carbon dioxide…

Biological Physics · Physics 2007-12-31 A. S. Kholodov , S. S. Simakov , Y. A. Kholodov , A. A. Nadolsky , A. N. Shushlebin

Many ion channels spontaneously switch between different levels of activity. Although this behaviour known as modal gating has been observed for a long time it is currently not well understood. Despite the fact that appropriately…

Quantitative Methods · Quantitative Biology 2018-08-14 Ivo Siekmann , Mark Fackrell , Edmund J. Crampin , Peter Taylor

The progress in imaging techniques have allowed the study of various aspect of cellular mechanisms. To isolate individual cells in live imaging data, we introduce an elegant image segmentation framework that effectively extracts cell…

Computer Vision and Pattern Recognition · Computer Science 2016-02-18 Arnaud Browet , Christophe De Vleeschouwer , Laurent Jacques , Navrita Mathiah , Bechara Saykali , Isabelle Migeotte

Computational fluid dynamics (CFD) based simulation of coronary blood flow provides valuable hemodynamic markers, such as pressure gradients, for diagnosing coronary artery disease (CAD). However, CFD is computationally expensive,…

Computer Vision and Pattern Recognition · Computer Science 2025-12-12 Rene Lisasi , Michele Esposito , Chen Zhao

Modern Bayesian inference involves a mixture of computational techniques for estimating, validating, and drawing conclusions from probabilistic models as part of principled workflows for data analysis. Typical problems in Bayesian workflows…

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