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This paper addresses patient heterogeneity associated with prediction problems in biomedical applications. We propose a systematic hypothesis testing approach to determine the existence of patient subgroup structure and the number of…

Methodology · Statistics 2021-01-08 Xu Gao , Weining Shen , Jing Ning , Ziding Feng , Jianhua Hu

Envelope model also known as multivariate regression model was proposed to solve the multiple response regression problems. It measures the linear association between predictors and multiple responses by using the minimal reducing subspace…

Methodology · Statistics 2018-05-07 Bochao Jia

Multimorbidity, the co-occurrence of two or more chronic diseases such as diabetes, obesity or cardiovascular diseases in one patient, is a frequent phenomenon. To make care more efficient, it is of relevance to understand how different…

Medical Physics · Physics 2019-08-05 Nils Haug , Stefan Thurner , Alexandra Kautzky-Willer , Michael Gyimesi , Peter Klimek

Heterogeneity has been a hot topic in recent educational literature. Several calls have been voiced to adopt methods that capture different patterns or subgroups within students behavior or functioning. Assuming that there is an average…

Methodology · Statistics 2023-06-13 Luca Scrucca , Mohammed Saqr , Sonsoles López-Pernas , Keefe Murphy

Recent advances in interrupted time series analysis permit characterization of a typical non-linear interruption effect through use of generalized additive models. Concurrently, advances in latent time series modeling allow efficient…

Applications · Statistics 2025-11-11 RJ Waken , Fengxian Wang , Sarah A. Eisenstein , Tim McBride , Kim Johnson , Karen Joynt-Maddox

We propose Bayesian model averaging (BMA) as a method for postprocessing the results of model-based clustering. Given a number of competing models, appropriate model summaries are averaged, using the posterior model probabilities, instead…

Computation · Statistics 2015-07-01 Niamh Russell , Thomas Brendan Murphy , Adrian E Raftery

Disease mapping is the field of spatial epidemiology interested in estimating the spatial pattern in disease risk across $n$ areal units. One aim is to identify units exhibiting elevated disease risks, so that public health interventions…

Applications · Statistics 2013-11-05 Craig Anderson , Duncan Lee , Nema Dean

Recently the patient-centered medical home (PCMH) model has become a popular team-based approach focused on delivering more streamlined care to patients. In current practices of medical homes, a clinical-based prediction frame is…

Applications · Statistics 2014-02-27 Saeede Ajorlou , Issac Shams , Kai Yang

We show that causal effects can be identified when there is bunching in the distribution of a continuous treatment variable, without imposing any parametric assumptions. This yields a new nonparametric method for overcoming selection bias…

Econometrics · Economics 2025-07-08 Carolina Caetano , Gregorio Caetano , Leonard Goff , Eric Nielsen

A Bayesian approach to conduct network model selection is presented for a general class of network models referred to as the congruence class models (CCMs). CCMs form a broad class that includes as special cases several common network…

Applications · Statistics 2020-01-22 Ravi Goyal , Victor De Gruttola

We propose completely nonparametric methodology to investigate location-scale modelling of two-component mixture cure models, where the responses of interest are only indirectly observable due to the presence of censoring and the presence…

Methodology · Statistics 2018-03-12 Justin Chown , Cedric Heuchenne , Ingrid Van Keilegom

In a multitude of industrial fields, a key objective entails optimising resource management whilst satisfying user requirements. Resource management by industrial practitioners can result in a passive transfer of user loads across resource…

Machine Learning · Computer Science 2023-09-26 Dongxu Lei , Xiaotian Lin , Xinghu Yu , Zhan Li , Weichao Sun , Jianbin Qiu , Songlin Zhuang , Huijun Gao

Count data frequently arises in biomedical applications, such as the length of hospital stay. However, their discrete nature poses significant challenges for appropriately modeling conditional quantiles, which are crucial for understanding…

Methodology · Statistics 2025-07-28 Yuta Yamauchi , Genya Kobayashi , Shonosuke Sugasawa

We present a dual-view mixture model to cluster users based on their features and latent behavioral functions. Every component of the mixture model represents a probability density over a feature view for observed user attributes and a…

Machine Learning · Computer Science 2018-12-19 Alberto Lumbreras , Julien Velcin , Marie Guégan , Bertrand Jouve

Healthcare foundation models have largely followed paradigms from natural language processing and computer vision, emphasizing large scale pretraining and deterministic representations over heterogeneous clinical data. However, clinical…

Machine Learning · Computer Science 2026-04-07 Qian Zhou , Yuanyun Zhang , Shi Li

A model based clustering procedure for data of mixed type, clustMD, is developed using a latent variable model. It is proposed that a latent variable, following a mixture of Gaussian distributions, generates the observed data of mixed type.…

Methodology · Statistics 2015-11-06 Damien McParland , Isobel Claire Gormley

Inferring dependence structure through undirected graphs is crucial for uncovering the major modes of multivariate interaction among high-dimensional genomic markers that are potentially associated with cancer. Traditionally, conditional…

Methodology · Statistics 2016-04-04 Anindya Bhadra , Arvind Rao , Veerabhadran Baladandayuthapani

In some contexts, mixture models can fit certain variables well at the expense of others in ways beyond the analyst's control. For example, when the data include some variables with non-trivial amounts of missing values, the mixture model…

Methodology · Statistics 2016-09-06 Maria DeYoreo , Jerome P. Reiter , D. Sunshine Hillygus

We describe a new method for evaluating Bayes factors. The key idea is to introduce a hypermodel in which the competing models are components of a mixture distribution. Inference for the mixing probabilities then yields estimates of the…

Methodology · Statistics 2016-02-16 Philip D. O'Neill , Theodore Kypraios

Disease progression modeling provides a robust framework to identify long-term disease trajectories from short-term biomarker data. It is a valuable tool to gain a deeper understanding of diseases with a long disease trajectory, such as…

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