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Comparing mathematical models offers a means to evaluate competing scientific theories. However, exact methods of model calibration are not applicable to many probabilistic models which simulate high-dimensional spatio-temporal data.…

Quantitative Methods · Quantitative Biology 2026-01-13 Robert A McDonald , Helen M Byrne , Heather A Harrington , Thomas Thorne , Bernadette J Stolz

We propose a robust and scalable procedure for general optimization and inference problems on manifolds leveraging the classical idea of `median-of-means' estimation. This is motivated by ubiquitous examples and applications in modern data…

Methodology · Statistics 2020-06-16 Lizhen Lin , Drew Lazar , Bayan Sarpabayeva , David B. Dunson

Classical unsupervised learning methods like clustering and linear dimensionality reduction parametrize large-scale geometry when it is discrete or linear, while more modern methods from manifold learning find low dimensional representation…

Machine Learning · Computer Science 2025-09-23 Luis Scoccola , Uzu Lim , Heather A. Harrington

Recent advances in cancer research largely rely on new developments in microscopic or molecular profiling techniques offering high level of detail with respect to either spatial or molecular features, but usually not both. Here, we present…

Statistical shape analysis can be done in a Riemannian framework by endowing the set of shapes with a Riemannian metric. Sobolev metrics of order two and higher on shape spaces of parametrized or unparametrized curves have several desirable…

Differential Geometry · Mathematics 2016-10-18 Martin Bauer , Martins Bruveris , Philipp Harms , Jakob Møller-Andersen

Current clinical decision-making in oncology relies on averages of large patient populations to both assess tumor status and treatment outcomes. However, cancers exhibit an inherent evolving heterogeneity that requires an individual…

We present a new manifold learning algorithm that takes a set of data points lying on or near a lower dimensional manifold as input, possibly with noise, and outputs a simplicial complex that fits the data and the manifold. We have…

Numerical Analysis · Mathematics 2012-09-17 Thomas Hunt , Arthur J. Krener

In statistical dimensionality reduction, it is common to rely on the assumption that high dimensional data tend to concentrate near a lower dimensional manifold. There is a rich literature on approximating the unknown manifold, and on…

Machine Learning · Statistics 2022-02-22 Didong Li , Minerva Mukhopadhyay , David B. Dunson

We present a novel kernel-based machine learning algorithm for identifying the low-dimensional geometry of the effective dynamics of high-dimensional multiscale stochastic systems. Recently, the authors developed a mathematical framework…

Dynamical Systems · Mathematics 2020-02-04 Andreas Bittracher , Stefan Klus , Boumediene Hamzi , Péter Koltai , Christof Schütte

Multidimensional data distributions can have complex topologies and variable local dimensions. To approximate complex data, we propose a new type of low-dimensional ``principal object'': a principal cubic complex. This complex is a…

Data Analysis, Statistics and Probability · Physics 2008-01-17 A. N. Gorban , N. R. Sumner , A. Y. Zinovyev

In image set classification, a considerable advance has been made by modeling the original image sets by second order statistics or linear subspace, which typically lie on the Riemannian manifold. Specifically, they are Symmetric Positive…

Computer Vision and Pattern Recognition · Computer Science 2018-05-31 Rui Wang , Xiao-Jun Wu , Kai-Xuan Chen , Josef Kittler

The existing approaches to intrinsic dimension estimation usually are not reliable when the data are nonlinearly embedded in the high dimensional space. In this work, we show that the explicit accounting to geometric properties of unknown…

Machine Learning · Statistics 2019-04-15 Marina Gomtsyan , Nikita Mokrov , Maxim Panov , Yury Yanovich

Research on manifold learning within a density ridge estimation framework has shown great potential in recent work for both estimation and de-noising of manifolds, building on the intuitive and well-defined notion of principal curves and…

Machine Learning · Statistics 2016-04-11 Jonas Nordhaug Myhre , Matineh Shaker , Devrim Kaba , Robert Jenssen , Deniz Erdogmus

This paper introduces an efficient multi-linear nonparametric (kernel-based) approximation framework for data regression and imputation, and its application to dynamic magnetic-resonance imaging (dMRI). Data features are assumed to reside…

Signal Processing · Electrical Eng. & Systems 2023-04-07 Duc Thien Nguyen , Konstantinos Slavakis

Analyzing large volumes of high-dimensional data is an issue of fundamental importance in data science, molecular simulations and beyond. Several approaches work on the assumption that the important content of a dataset belongs to a…

Machine Learning · Statistics 2018-03-20 Elena Facco , Maria d'Errico , Alex Rodriguez , Alessandro Laio

Motivated by the problem of nonparametric inference in high level digital image analysis, we introduce a general extrinsic approach for data analysis on Hilbert manifolds with a focus on means of probability distributions on such sample…

Statistics Theory · Mathematics 2013-02-11 Leif Ellingson , Vic Patrangenaru , Frits Ruymgaart

Insightful visualization of multidimensional scalar fields, in particular parameter spaces, is key to many fields in computational science and engineering. We propose a principal component-based approach to visualize such fields that…

Graphics · Computer Science 2018-09-12 Rafael Ballester-Ripoll , Renato Pajarola

Image classification is widely used to build predictive models for breast cancer diagnosis. Most existing approaches overwhelmingly rely on deep convolutional networks to build such diagnosis pipelines. These model architectures, although…

Image and Video Processing · Electrical Eng. & Systems 2022-01-20 Alireza Rezazadeh , Yasamin Jafarian , Ali Kord

Data augmentation for deep learning benefits model training, image transformation, medical imaging analysis and many other fields. Many existing methods generate new samples from a parametric distribution, like the Gaussian, with little…

Computer Vision and Pattern Recognition · Computer Science 2023-10-13 Elvis Han Cui , Bingbin Li , Yanan Li , Weng Kee Wong , Donghui Wang

One of the fundamental problems in machine learning is the estimation of a probability distribution from data. Many techniques have been proposed to study the structure of data, most often building around the assumption that observations…

Machine Learning · Statistics 2013-02-22 Oren Rippel , Ryan Prescott Adams