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We propose an experimental scheme for performing sensitive, high-precision laser spectroscopy studies on fast exotic isotopes. By inducing a step-wise resonant ionization of the atoms travelling inside an electric field and subsequently…

Nuclear Experiment · Physics 2024-03-04 Silviu-Marian Udrescu , Diego Alejandro Torres , Ronald Fernando Garcia Ruiz

Usually, lesions are not isolated but are associated with the surrounding tissues. For example, the growth of a tumour can depend on or infiltrate into the surrounding tissues. Due to the pathological nature of the lesions, it is…

Image and Video Processing · Electrical Eng. & Systems 2022-10-12 Lin Wang , Xiufen Ye , Donghao Zhang , Wanji He , Lie Ju , Yi Luo , Huan Luo , Xin Wang , Wei Feng , Kaimin Song , Xin Zhao , Zongyuan Ge

Prompt engineering is a crucial yet challenging task for optimizing the performance of large language models (LLMs) on customized tasks. This pioneering research introduces the Automatic Prompt Engineering Toolbox (APET), which enables…

Computation and Language · Computer Science 2024-07-17 Daan Kepel , Konstantina Valogianni

Rationale: In a shotgun proteomics experiment with data-dependent acquisition, real-time analysis of a precursor scan results in selection of a handful of peaks for subsequent isolation, fragmentation and secondary scanning. This peak…

Quantitative Methods · Quantitative Biology 2012-07-26 Benjamin J. Diament , Michael J. MacCoss , William Stafford Noble

Evaluating anomaly detection algorithms in time series data is critical as inaccuracies can lead to flawed decision-making in various domains where real-time analytics and data-driven strategies are essential. Traditional performance…

Machine Learning · Computer Science 2024-05-21 Ramin Ghorbani , Marcel J. T. Reinders , David M. J. Tax

In this paper, we present HOLMES, a system that implements a new approach to the detection of Advanced and Persistent Threats (APTs). HOLMES is inspired by several case studies of real-world APTs that highlight some common goals of APT…

Cryptography and Security · Computer Science 2019-01-21 Sadegh M. Milajerdi , Rigel Gjomemo , Birhanu Eshete , R. Sekar , V. N. Venkatakrishnan

A novel approach for structure alignment is presented, where the key ingredients are: (1) An error function formulation of the problem simultaneously in terms of binary (Potts) assignment variables and real-valued atomic coordinates. (2)…

Biological Physics · Physics 2007-05-23 M. Ohlsson , C. Peterson , M. Ringner , R. Blankenbecler

Optical projection tomography (OPT) is a powerful tool for biomedical studies. It achieves 3D visualization of mesoscopic biological samples with high spatial resolution using conventional tomographic-reconstruction algorithms. However,…

Computer Vision and Pattern Recognition · Computer Science 2023-10-02 Yan Liu , Jonathan Dong , Thanh-An Pham , Francois Marelli , Michael Unser

Identifying a small molecule from its mass spectrum is the primary open problem in computational metabolomics. This is typically cast as information retrieval: an unknown spectrum is matched against spectra predicted computationally from a…

Machine Learning · Computer Science 2023-01-30 Michael Murphy , Stefanie Jegelka , Ernest Fraenkel , Tobias Kind , David Healey , Thomas Butler

Human preference data is essential for aligning large language models (LLMs) with human values, but collecting such data is often costly and inefficient-motivating the need for efficient data selection methods that reduce annotation costs…

Computation and Language · Computer Science 2026-04-21 Seohyeong Lee , Eunwon Kim , Hwaran Lee , Buru Chang

Tilt-to-length (TTL) coupling, caused by the jitter of test masses or satellites, is a significant noise source in space-based gravitational wave detection. Calibrating and suppressing TTL coupling noise at the sub-nanometer level is…

Instrumentation and Methods for Astrophysics · Physics 2024-08-05 Xiang Lin , Qi Xia , Peng Qiu , Yurong Liang , Hao Yan

Optical projection tomography (OPT) is a powerful tool for biomedical studies. It achieves 3D visualization of mesoscopic biological samples with high spatial resolution using conventional tomographic-reconstruction algorithms. However,…

Optics · Physics 2025-02-07 Yan Liu , Jonathan Dong , Thanh-an Pham , François Marelli , Michael Unser

Motivation: Mass spectrometry-based proteomics is among the most commonly used methods for scrutinizing proteomic profiles in different organs for biological or medical researches. All the proteomic analyses including peptide/protein…

Quantitative Methods · Quantitative Biology 2017-11-01 Chunwei Ma

Device variability is a bottleneck for the scalability of semiconductor quantum devices. Increasing device control comes at the cost of a large parameter space that has to be explored in order to find the optimal operating conditions. We…

Scanning Transmission Electron Microscopy (STEM) enables the observation of atomic arrangements at sub-angstrom resolution, allowing for atomically resolved analysis of the physical and chemical properties of materials. However, due to the…

Computer Vision and Pattern Recognition · Computer Science 2025-04-04 Hesong Li , Ziqi Wu , Ruiwen Shao , Tao Zhang , Ying Fu

Recognition of individual components and keypoint detection supported by instance segmentation is crucial to analyze the behavior of agents on the scene. Such systems could be used for surveillance, self-driving cars, and also for medical…

Computer Vision and Pattern Recognition · Computer Science 2024-05-09 László Kopácsi , Áron Fóthi , András Lőrincz

Supervised machine learning often requires large training sets to train accurate models, yet obtaining large amounts of labeled data is not always feasible. Hence, it becomes crucial to explore active learning methods for reducing the size…

Machine Learning · Computer Science 2024-04-16 Ashna Jose , Emilie Devijver , Massih-Reza Amini , Noel Jakse , Roberta Poloni

Path planning is an active area of research essential for many applications in robotics. Popular techniques include graph-based searches and sampling-based planners. These approaches are powerful but have limitations. This paper continues…

Robotics · Computer Science 2020-12-10 Marlin P. Strub , Jonathan D. Gammell

Automated tumor detection in Digital Breast Tomosynthesis (DBT) is a difficult task due to natural tumor rarity, breast tissue variability, and high resolution. Given the scarcity of abnormal images and the abundance of normal images for…

Image and Video Processing · Electrical Eng. & Systems 2024-07-24 Nicholas Konz , Haoyu Dong , Maciej A. Mazurowski

Characterising large-scale quantum systems is central to fundamental physics and essential for applications of quantum technologies. While a full characterisation requires exponentially increasing resources, focusing on application-relevant…