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Conditional independence testing (CIT) is essential for reliable scientific discovery. It prevents spurious findings and enables controlled feature selection. Recent CIT methods have used machine learning (ML) models as surrogates of the…

Statistics Theory · Mathematics 2026-02-02 Angel Reyero-Lobo , Bertrand Thirion , Pierre Neuvial

We consider testing marginal independence versus conditional independence in a trivariate Gaussian setting. The two models are non-nested and their intersection is a union of two marginal independences. We consider two sequences of such…

Statistics Theory · Mathematics 2020-10-23 F. Richard Guo , Thomas S. Richardson

The maximal information coefficient (MIC), which measures the amount of dependence between two variables, is able to detect both linear and non-linear associations. However, computational cost grows rapidly as a function of the dataset…

Information Theory · Computer Science 2015-08-18 Ali Mousavi , Richard G. Baraniuk

A new test of independence between random elements is presented in this article. The test is based on a functional of the Cram\'{e}r-von Mises type, which is applied to a $U$-process that is defined from the recurrence rates. Theorems of…

Statistics Theory · Mathematics 2019-08-12 Juan Kalemkerian , Diego Fernández

Estimating mutual information (MI) from samples is a fundamental problem in statistics, machine learning, and data analysis. Recently it was shown that a popular class of non-parametric MI estimators perform very poorly for strongly…

Information Theory · Computer Science 2016-02-18 Shuyang Gao , Greg Ver Steeg , Aram Galstyan

We introduce two novel non-parametric statistical hypothesis tests. The first test, called the relative test of dependency, enables us to determine whether one source variable is significantly more dependent on a first target variable or a…

Artificial Intelligence · Computer Science 2016-11-18 Wacha Bounliphone , Eugene Belilovsky , Arthur Tenenhaus , Ioannis Antonoglou , Arthur Gretton , Matthew B. Blashcko

Detecting conditional independencies plays a key role in several statistical and machine learning tasks, especially in causal discovery algorithms. In this study, we introduce LCIT (Latent representation based Conditional Independence…

Machine Learning · Computer Science 2022-09-07 Bao Duong , Thin Nguyen

Testing the equality of two high-dimensional mean vectors is a fundamental problem in multivariate analysis. While the classical Hotelling's $T^2$ test is optimal in low-dimensional settings, it fails when the dimension $p$ is comparable to…

Methodology · Statistics 2026-05-22 Minsub Shin , Kwangok Seo , Sang Han Lee , Johan Lim

For a set of dependent random variables, without stationary or the strong mixing assumptions, we derive the asymptotic independence between their sums and maxima. Then we apply this result to high-dimensional testing problems, where we…

Methodology · Statistics 2022-05-12 Long Feng , Tiefeng Jiang , Xiaoyun Li , Binghui Liu

We propose a novel approach to concentration for non-independent random variables. The main idea is to ``pretend'' that the random variables are independent and pay a multiplicative price measuring how far they are from actually being…

Information Theory · Computer Science 2023-10-31 Amedeo Roberto Esposito , Marco Mondelli

We consider the problem of testing mutual independence among the components of a high-dimensional random vector. Building on the rank-based max-sum framework, we introduce fixed finite-$L_q$ power-sum statistics under three general classes…

Methodology · Statistics 2026-05-26 Ping Zhao , Hongfei Wang , Long Feng

Identifying dependency in multivariate data is a common inference task that arises in numerous applications. However, existing nonparametric independence tests typically require computation that scales at least quadratically with the sample…

Methodology · Statistics 2021-07-08 Shai Gorsky , Li Ma

In this paper we develop a novel nonparametric framework to test the independence of two random variables $\mathbf{X}$ and $\mathbf{Y}$ with unknown respective marginals $H(dx)$ and $G(dy)$ and joint distribution $F(dx dy)$, based on {\it…

Statistics Theory · Mathematics 2024-03-20 Myrto Limnios , Stéphan Clémençon

Conditional independence tests (CITs) test for conditional dependence between random variables. As existing CITs are limited in their applicability to complex, high-dimensional variables such as images, we introduce deep nonparametric CITs…

Machine Learning · Statistics 2024-11-12 Marco Simnacher , Xiangnan Xu , Hani Park , Christoph Lippert , Sonja Greven

Information-theoretic quantities like entropy and mutual information have found numerous uses in machine learning. It is well known that there is a strong connection between these entropic quantities and submodularity since entropy over a…

Machine Learning · Computer Science 2021-03-04 Rishabh Iyer , Ninad Khargonkar , Jeff Bilmes , Himanshu Asnani

Mutual information (MI) is one of the most general ways to measure relationships between random variables, but estimating this quantity for complex systems is challenging. Denoising diffusion models have recently set a new bar for density…

Machine Learning · Computer Science 2025-11-20 Longxuan Yu , Xing Shi , Xianghao Kong , Tong Jia , Greg Ver Steeg

Mutual information (MI) is a fundamental measure of statistical dependence between two variables, yet accurate estimation from finite data remains notoriously difficult. No estimator is universally reliable, and common approaches fail in…

Data Analysis, Statistics and Probability · Physics 2025-10-02 Eslam Abdelaleem , K. Michael Martini , Ilya Nemenman

We study the problems of sequential nonparametric two-sample and independence testing. Sequential tests process data online and allow using observed data to decide whether to stop and reject the null hypothesis or to collect more data,…

Machine Learning · Statistics 2023-07-21 Aleksandr Podkopaev , Aaditya Ramdas

In this paper, we introduce a ${\mathcal L}_2$ type test for testing mutual independence and banded dependence structure for high dimensional data. The test is constructed based on the pairwise distance covariance and it accounts for the…

Methodology · Statistics 2017-09-20 Shun Yao , Xianyang Zhang , Xiaofeng Shao

The probability integral transform (PIT) of a continuous random variable $X$ with distribution function $F_X$ is a uniformly distributed random variable $U=F_X(X)$. We define the angular probability integral transform (APIT) as $\theta_U =…

Methodology · Statistics 2025-01-10 Fernández-Durán , J. J. , Gregorio-Domínguez , M. M