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Seasonal influenza presents an ongoing challenge to public health. The rapid evolution of the flu virus necessitates annual vaccination campaigns, but the decision to get vaccinated or not in a given year is largely voluntary, at least in…

Populations and Evolution · Quantitative Biology 2021-01-21 Irena Papst , Kevin P. O'Keeffe , Steven H. Strogatz

In many applications, evaluating the effectiveness of different alternatives comes with varying costs or resource usage. Motivated by such heterogeneity, we study the Best Arm Identification with Resource Constraints (BAIwRC) problem, where…

Machine Learning · Computer Science 2026-03-02 Zitian Li , Wang Chi Cheung

We here adopt Bayesian nonparametric mixture models to extend multi-armed bandits in general, and Thompson sampling in particular, to scenarios where there is reward model uncertainty. In the stochastic multi-armed bandit, the reward for…

Machine Learning · Statistics 2022-08-26 Iñigo Urteaga , Chris H. Wiggins

We propose a new integrated phase I/II trial design to identify the most efficacious dose combination that also satisfies certain safety requirements for drug-combination trials. We first take a Bayesian copula-type model for dose finding…

Applications · Statistics 2011-08-09 Ying Yuan , Guosheng Yin

In this paper we consider robust models for emergency staff deployment in the event of a flu pandemic. We focus on managing critical staff levels at organizations that must remain operational during such an event, and develop methodologies…

Optimization and Control · Mathematics 2015-07-31 Daniel Bienstock , A. Cecilia Zenteno

We study how international flights can facilitate the spread of an epidemic to a worldwide scale. We combine an infrastructure network of flight connections with a population density dataset to derive the mobility network, and then we…

Physics and Society · Physics 2021-07-26 Hugo Dolan , Riccardo Rastelli

Compartmental models have long served as important tools in mathematical epidemiology, with their usefulness highlighted by the recent COVID-19 pandemic. However, most of the classical models fail to account for certain features of this…

Dynamical Systems · Mathematics 2023-08-21 Monique Chyba , Taylor Klotz , Yuriy Mileyko , Corey Shanbrom

We propose a new strategy for best-arm identification with fixed confidence of Gaussian variables with bounded means and unit variance. This strategy, called Exploration-Biased Sampling, is not only asymptotically optimal: it is to the best…

Statistics Theory · Mathematics 2022-03-08 Antoine Barrier , Aurélien Garivier , Tomáš Kocák

Bayesian optimization has become a popular method for high-throughput computing, like the design of computer experiments or hyperparameter tuning of expensive models, where sample efficiency is mandatory. In these applications, distributed…

Machine Learning · Computer Science 2019-07-08 Javier Garcia-Barcos , Ruben Martinez-Cantin

Gathering labeled data to train well-performing machine learning models is one of the critical challenges in many applications. Active learning aims at reducing the labeling costs by an efficient and effective allocation of costly labeling…

Machine Learning · Computer Science 2020-06-03 Daniel Kottke , Marek Herde , Christoph Sandrock , Denis Huseljic , Georg Krempl , Bernhard Sick

We study best arm identification in a variant of the multi-armed bandit problem where the learner has limited precision in arm selection. The learner can only sample arms via certain exploration bundles, which we refer to as boxes. In…

Machine Learning · Computer Science 2023-05-11 Kota Srinivas Reddy , P. N. Karthik , Nikhil Karamchandani , Jayakrishnan Nair

We introduce Box Thirding (B3), a flexible and efficient algorithm for Best Arm Identification (BAI) under fixed-budget constraints. It is designed for both anytime BAI and scenarios with large N, where the number of arms is too large for…

Machine Learning · Statistics 2026-02-23 Seohwa Hwang , Junyong Park

Mobile health (mHealth) programs face a critical challenge in optimizing the timing of automated health information calls to beneficiaries. This challenge has been formulated as a collaborative multi-armed bandit problem, requiring online…

Machine Learning · Computer Science 2024-10-31 Arpan Dasgupta , Gagan Jain , Arun Suggala , Karthikeyan Shanmugam , Milind Tambe , Aparna Taneja

A central challenge in every field of biology is to use existing measurements to predict the outcomes of future experiments. In this work, we consider the wealth of antibody inhibition data against variants of the influenza virus. Due to…

Quantitative Methods · Quantitative Biology 2023-07-27 Tal Einav , Rong Ma

The transmission dynamics of an epidemic are rarely homogeneous. Super-spreading events and super-spreading individuals are two types of heterogeneous transmissibility. Inference of super-spreading is commonly carried out on secondary case…

Quantitative Methods · Quantitative Biology 2025-01-23 Hannah Craddock , Simon EF Spencer , Xavier Didelot

Predicting epidemic dynamics is of great value in understanding and controlling diffusion processes, such as infectious disease spread and information propagation. This task is intractable, especially when surveillance resources are very…

Machine Learning · Statistics 2017-12-04 Hongbin Pei , Bo Yang , Jiming Liu , Lei Dong

Epidemic models play a key role in understanding and responding to the emerging COVID-19 pandemic. Widely used compartmental models are static and are of limited use to evaluate intervention strategies with the emerging pandemic. Applying…

Populations and Evolution · Quantitative Biology 2021-01-01 Shuo Wang , Xian Yang , Ling Li , Philip Nadler , Rossella Arcucci , Yuan Huang , Zhongzhao Teng , Yike Guo

Epidemiological models can not only be used to forecast the course of a pandemic like COVID-19, but also to propose and design non-pharmaceutical interventions such as school and work closing. In general, the design of optimal policies…

Optimization and Control · Mathematics 2023-04-06 Jan-Hendrik Niemann , Samuel Uram , Sarah Wolf , Nataša Djurdjevac Conrad , Martin Weiser

We review research papers which use game theory to model the decision making of individuals during an epidemic, attempting to classify the literature and identify the emerging trends in this field. We show that the literature can be…

Populations and Evolution · Quantitative Biology 2020-02-13 Sheryl L. Chang , Mahendra Piraveenan , Philippa Pattison , Mikhail Prokopenko

In good arm identification (GAI), the goal is to identify one arm whose average performance exceeds a given threshold, referred to as a good arm, if it exists. Few works have studied GAI in the fixed-budget setting when the sampling budget…

Machine Learning · Statistics 2026-01-08 Marc Jourdan , Andrée Delahaye-Duriez , Clémence Réda