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Patient-specific hemodynamics assessment could support diagnosis and treatment of neurovascular diseases. Currently, conventional medical imaging modalities are not able to accurately acquire high-resolution hemodynamic information that…

Non-contact measurement of the refractive index and thickness of multilayer biological tissues is of great significance for biomedical applications and can greatly improve medical diagnosis and treatment. In this work, we introduce a…

Optics · Physics 2024-04-19 Yu-Lin Ku , Yao-Gen Shu

Optical coherence tomography angiography (OCTA) has been established as a powerful tool for investigating vascular diseases and is expected to become a standard of care technology. However, its widespread clinical usage is hindered by…

Medical Physics · Physics 2021-09-10 Si Chen , Kan Lin , Linbo Liu

Automatic motion compensation and adjustment of an intraoperative imaging modality's field of view is a common problem during interventions. Optical coherence tomography (OCT) is an imaging modality which is used in interventions due to its…

Computer Vision and Pattern Recognition · Computer Science 2019-03-12 Nils Gessert , Martin Gromniak , Matthias Schlüter , Alexander Schlaefer

Optical coherence tomography (OCT) has stimulated a wide range of medical image-based diagnosis and treatment in fields such as cardiology and ophthalmology. Such applications can be further facilitated by deep learning-based…

Medical Physics · Physics 2023-07-24 Xueshen Li , Zhenxing Dong , Hongshan Liu , Jennifer J. Kang-Mieler , Yuye Ling , Yu Gan

It is common to introduce optical tweezers using either geometric optics for large particles or the Rayleigh approximation for very small particles. These approaches are successful at conveying the key ideas behind optical tweezers in their…

In order to realize fast OCT-systems with adjustable line rate, we investigate averaging of image data from an FDML based MHz-OCT-system. The line rate can be reduced in software and traded in for increased system sensitivity and image…

Optical coherence tomography (OCT) has proven to be a powerful technique for studying tissue morphology in ophthalmology, cardiology, and endomicroscopy. Its performance is limited by the fundamental trade-off between the imaging…

Optics · Physics 2008-02-27 Keisuke Goda , Daniel R. Solli , Bahram Jalali

Multiple light scattering in tissue limits the penetration of optical coherence tomography (OCT) imaging. Here, we present in-vivo OCT imaging of a live mouse using wavefront shaping to enhance the penetration depth. A digital micro-mirror…

Optical coherence tomography (OCT) is a popular modality in ophthalmology and is also used intravascularly. Our interest in this work is OCT in the context of airway abnormalities in infants and children where the high resolution of OCT and…

Image and Video Processing · Electrical Eng. & Systems 2024-03-19 Yining Jiao , Amy Oldenburg , Yinghan Xu , Srikamal Soundararajan , Carlton Zdanski , Julia Kimbell , Marc Niethammer

While optical coherence tomography (OCT) provides a resolution down to 1 micrometer it has difficulties to visualize cellular structures due to a lack of scattering contrast. By evaluating signal fluctuations, a significant contrast…

Speckle noise has long been an extensively studied problem in medical imaging. In recent years, there have been significant advances in leveraging deep learning methods for noise reduction. Nevertheless, adaptation of supervised learning…

Image and Video Processing · Electrical Eng. & Systems 2023-06-21 Deborah Pereg

We report a new computational model for simulations of electromagnetic interactions with semiconductor quantum well(s) (SQW) in complex electromagnetic geometries using the finite difference time domain (FDTD) method. The presented model is…

Optics · Physics 2015-03-20 Koustuban Ravi , Qian Wang , Seng-Tiong Ho

Providing quantitative interpretation of coherent nonlinear microscopy images, such as third-harmonic generation (THG), is generally hampered by the complex phase-matching conditions, especially in the presence of sample linear…

Optics · Physics 2026-03-09 Mohammad Reza Farhadinia , Nicolas Olivier

Quantum Optical Coherence Tomography (Q-OCT) is a non-classical equivalent of Optical Coherence Tomography and is able to provide a twofold axial resolution increase and immunity to resolution-degrading dispersion. The main drawback of…

Signal Processing · Electrical Eng. & Systems 2021-04-22 Sylwia M. Kolenderska , Maciej Szkulmowski

Optical coherence tomography (OCT) is a non-invasive imaging technique widely used for ophthalmology. It can be extended to OCT angiography (OCT-A), which reveals the retinal vasculature with improved contrast. Recent deep learning…

Image and Video Processing · Electrical Eng. & Systems 2021-07-12 Dewei Hu , Can Cui , Hao Li , Kathleen E. Larson , Yuankai K. Tao , Ipek Oguz

Optical coherence tomography (OCT) is a prevalent imaging technique for retina. However, it is affected by multiplicative speckle noise that can degrade the visibility of essential anatomical structures, including blood vessels and tissue…

Image and Video Processing · Electrical Eng. & Systems 2021-07-12 Dewei Hu , Joseph D. Malone , Yigit Atay , Yuankai K. Tao , Ipek Oguz

Optical coherence tomography (OCT) and confocal microscopy are pivotal in retinal imaging, offering distinct advantages and limitations. In vivo OCT offers rapid, non-invasive imaging but can suffer from clarity issues and motion artifacts,…

Image and Video Processing · Electrical Eng. & Systems 2024-12-18 Xin Tian , Nantheera Anantrasirichai , Lindsay Nicholson , Alin Achim

Optical diffraction tomography (ODT) is a tomographic technique that can be used to measure the three-dimensional (3D) refractive index distribution within living cells without the requirement of any marker. In principle, ODT can be…

Quantitative Methods · Quantitative Biology 2018-01-03 Paul Müller , Mirjam Schürmann , Chii J. Chan , Jochen Guck

Mid-infrared light scatters much less than shorter wavelengths, allowing greatly enhanced penetration depths for optical imaging techniques such as optical coherence tomography (OCT). However, both detection and broadband sources in the…