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Metastability is a common obstacle to performing long molecular dynamics simulations. Many numerical methods have been proposed to overcome it. One method is parallel replica dynamics, which relies on the rapid convergence of the underlying…

Numerical Analysis · Mathematics 2015-05-20 Andrew Binder , Tony Lelièvre , Gideon Simpson

Genetic data are frequently categorical and have complex dependence structures that are not always well understood. For this reason, clustering and classification based on genetic data, while highly relevant, are challenging statistical…

Methodology · Statistics 2016-06-13 Gabriela Bettella Cybis , Marcio Valk , Silvia Regina Costa Lopes

We study the evolution of artificial learning systems by means of selection. Genetic programming is used to generate a sequence of populations of algorithms which can be used by neural networks for supervised learning of a rule that…

Biological Physics · Physics 2009-11-07 Juan Pablo Neirotti , Nestor Caticha

In this paper, we consider the problem of partitioning a small data sample of size $n$ drawn from a mixture of $2$ sub-gaussian distributions. Our work is motivated by the application of clustering individuals according to their population…

Statistics Theory · Mathematics 2023-01-05 Shuheng Zhou

The Massive Parallel Computing (MPC) model gained popularity during the last decade and it is now seen as the standard model for processing large scale data. One significant shortcoming of the model is that it assumes to work on static…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-05-23 Giuseppe F. Italiano , Silvio Lattanzi , Vahab S. Mirrokni , Nikos Parotsidis

We study the inverse problem of deducing the dynamical characteristics (such as the potential field) of large systems from kinematic observations. We show that, for a class of steady-state systems, the solution is unique even with…

Astrophysics · Physics 2008-11-14 Mikko Kaasalainen

Modelling, analysing and inferring triggering mechanisms in population reproduction is fundamental in many biological applications. It is also an active and growing research domain in mathematical biology. In this chapter, we review the…

Analysis of PDEs · Mathematics 2023-01-09 Marie Doumic , Marc Hoffmann

Identifying drivers of complex traits from the noisy signals of genetic variation obtained from high throughput genome sequencing technologies is a central challenge faced by human geneticists today. We hypothesize that the variants…

Populations and Evolution · Quantitative Biology 2013-06-18 M. Cyrus Maher , Lawrence H. Uricchio , Dara G. Torgerson , Ryan D. Hernandez

We propose a novel method for numerical modeling of spatially inhomogeneous moment dynamics of populations with nonlocal dispersal and competition in continuous space. It is based on analytically solvable decompositions of the time…

Populations and Evolution · Quantitative Biology 2019-07-24 Igor Omelyan , Yuri Kozitsky

In this paper we consider functional data with heterogeneity in time and in population. We propose a mixture model with segmentation of time to represent this heterogeneity while keeping the functional structure. Maximum likelihood…

Methodology · Statistics 2024-07-24 Vincent Brault , Émilie Devijver , Charlotte Laclau

We obtain the exact large deviation functions of the density profile and of the current, in the non-equilibrium steady state of a one dimensional symmetric simple exclusion process coupled to boundary reservoirs with slow rates. Compared to…

Statistical Mechanics · Physics 2021-02-03 Bernard Derrida , Ori Hirschberg , Tridib Sadhu

A hybrid evolutionary algorithm with importance sampling method is proposed for multi-dimensional optimization problems in this paper. In order to make use of the information provided in the search process, a set of visited solutions is…

Neural and Evolutionary Computing · Computer Science 2013-08-26 Guanghui Huang , Zhifeng Pan

Coalescent theory combined with statistical modeling allows us to estimate effective population size fluctuations from molecular sequences of individuals sampled from a population of interest. When sequences are sampled serially through…

Populations and Evolution · Quantitative Biology 2021-11-02 Michael D. Karcher , Marc A. Suchard , Gytis Dudas , Vladimir N. Minin

In this article, a stochastic individual-based model describing Darwinian evolution of asexual, phenotypic trait-structured population, is studied. We consider a large population with constant population size characterised by a resampling…

Probability · Mathematics 2024-07-09 Nicolas Champagnat , Vincent Hass

In this paper we propose a crossover operator for evolutionary algorithms with real values that is based on the statistical theory of population distributions. The operator is based on the theoretical distribution of the values of the genes…

Neural and Evolutionary Computing · Computer Science 2011-09-13 N. García-Pedrajas , C. Hervás-Martínez , D. Ortiz-Boyer

To analyse a very large data set containing lengthy variables, we adopt a sequential estimation idea and propose a parallel divide-and-conquer method. We conduct several conventional sequential estimation procedures separately, and properly…

Methodology · Statistics 2018-12-27 Zhanfeng Wang , Yuan-chin Ivan Chang

Divergence is not only an important mathematical concept in information theory, but also applied to machine learning problems such as low-dimensional embedding, manifold learning, clustering, classification, and anomaly detection. We…

Computation · Statistics 2016-11-22 Kun Yang , Hao Su , Wing Hung Wong

We study the convergence of statistical estimators used in the estimation of large deviation functions describing the fluctuations of equilibrium, nonequilibrium, and manmade stochastic systems. We give conditions for the convergence of…

Statistical Mechanics · Physics 2015-11-09 Christian M. Rohwer , Florian Angeletti , Hugo Touchette

The era of huge data necessitates highly efficient machine learning algorithms. Many common machine learning algorithms, however, rely on computationally intensive subroutines that are prohibitively expensive on large datasets. Oftentimes,…

Machine Learning · Computer Science 2023-09-26 Mo Tiwari

Statistical divergence is widely applied in multimedia processing, basically due to regularity and interpretable features displayed in data. However, in a broader range of data realm, these advantages may no longer be feasible, and…

Databases · Computer Science 2020-11-20 Ruoyu Wang , Xiaobo Hu , Daniel Sun , Guoqiang Li , Raymond Wong , Shiping Chen , Jianquan Liu