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Deep generative models often perform poorly in real-world applications due to the heterogeneity of natural data sets. Heterogeneity arises from data containing different types of features (categorical, ordinal, continuous, etc.) and…

Machine Learning · Computer Science 2020-06-23 Chao Ma , Sebastian Tschiatschek , José Miguel Hernández-Lobato , Richard Turner , Cheng Zhang

This study investigates the use of non-linear unsupervised dimensionality reduction techniques to compress a music dataset into a low-dimensional representation which can be used in turn for the synthesis of new sounds. We systematically…

Audio and Speech Processing · Electrical Eng. & Systems 2019-05-27 Fanny Roche , Thomas Hueber , Samuel Limier , Laurent Girin

Successfully training Variational Autoencoders (VAEs) with a hierarchy of discrete latent variables remains an area of active research. Vector-Quantised VAEs are a powerful approach to discrete VAEs, but naive hierarchical extensions can be…

Machine Learning · Statistics 2021-02-05 Matthew Willetts , Xenia Miscouridou , Stephen Roberts , Chris Holmes

There exists unexplained diverse variation within the predefined colon cancer stages using only features either from genomics or histopathological whole slide images as prognostic factors. Unraveling this variation will bring about improved…

Quantitative Methods · Quantitative Biology 2022-12-15 Olalekan Ogundipe , Zeyneb Kurt , Wai Lok Woo

A feature learning task involves training models that are capable of inferring good representations (transformations of the original space) from input data alone. When working with limited or unlabelled data, and also when multiple visual…

Computer Vision and Pattern Recognition · Computer Science 2018-11-02 Gabriel B. Cavallari , Leonardo Sampaio Ferraz Ribeiro , Moacir Antonelli Ponti

By composing graphical models with deep learning architectures, we learn generative models with the strengths of both frameworks. The structured variational autoencoder (SVAE) inherits structure and interpretability from graphical models,…

Machine Learning · Computer Science 2023-11-15 Harry Bendekgey , Gabriel Hope , Erik B. Sudderth

In this study, we present Flatsomatic - a Variational Auto Encoder (VAE) optimized to compress somatic mutations that allow for unbiased data compression whilst maintaining the signal. We compared two different neural network architectures…

Image and Video Processing · Electrical Eng. & Systems 2019-12-02 Geoffroy Dubourg-Felonneau , Yasmeen Kussad , Dominic Kirkham , John W Cassidy , Nirmesh Patel , Harry W Clifford

Deep generative models have been praised for their ability to learn smooth latent representation of images, text, and audio, which can then be used to generate new, plausible data. However, current generative models are unable to work with…

Machine Learning · Computer Science 2019-09-09 Bidisha Samanta , Abir De , Gourhari Jana , Pratim Kumar Chattaraj , Niloy Ganguly , Manuel Gomez-Rodriguez

The interactions between tumor cells and the tumor microenvironment (TME) dictate therapeutic efficacy of radiation and many systemic therapies in breast cancer. However, to date, there is not a widely available method to reproducibly…

Variational Auto-Encoders (VAEs) are capable of learning latent representations for high dimensional data. However, due to the i.i.d. assumption, VAEs only optimize the singleton variational distributions and fail to account for the…

Machine Learning · Computer Science 2020-04-20 Da Tang , Dawen Liang , Tony Jebara , Nicholas Ruozzi

Human face exhibits an inherent hierarchy in its representations (i.e., holistic facial expressions can be encoded via a set of facial action units (AUs) and their intensity). Variational (deep) auto-encoders (VAE) have shown great results…

Computer Vision and Pattern Recognition · Computer Science 2017-08-08 Dieu Linh Tran , Robert Walecki , Ognjen Rudovic , Stefanos Eleftheriadis , Bjørn Schuller , Maja Pantic

This study advances the Variational Autoencoder (VAE) framework by addressing challenges in Independent Component Analysis (ICA) under both determined and underdetermined conditions, focusing on enhancing the independence and…

Machine Learning · Statistics 2025-06-10 Yuan-Hao Wei , Yan-Jie Sun

Variational Autoencoders (VAEs) provide a theoretically-backed and popular framework for deep generative models. However, learning a VAE from data poses still unanswered theoretical questions and considerable practical challenges. In this…

Machine Learning · Computer Science 2020-06-01 Partha Ghosh , Mehdi S. M. Sajjadi , Antonio Vergari , Michael Black , Bernhard Schölkopf

We present a detailed study on Variational Autoencoders (VAEs) for anomalous jet tagging at the Large Hadron Collider. By taking in low-level jet constituents' information, and training with background QCD jets in an unsupervised manner,…

High Energy Physics - Phenomenology · Physics 2023-01-05 Taoli Cheng , Jean-François Arguin , Julien Leissner-Martin , Jacinthe Pilette , Tobias Golling

The de novo design of drug molecules is recognized as a time-consuming and costly process, and computational approaches have been applied in each stage of the drug discovery pipeline. Variational autoencoder is one of the computer-aided…

Quantum Physics · Physics 2021-12-24 Junde Li , Swaroop Ghosh

Graph structured data are abundant in the real world. Among different graph types, directed acyclic graphs (DAGs) are of particular interest to machine learning researchers, as many machine learning models are realized as computations on…

Machine Learning · Computer Science 2019-10-30 Muhan Zhang , Shali Jiang , Zhicheng Cui , Roman Garnett , Yixin Chen

Variational autoencoders (VAEs) are one class of generative probabilistic latent-variable models designed for inference based on known data. We develop three variations on VAEs by introducing a second parameterized encoder/decoder pair and,…

Machine Learning · Computer Science 2023-04-06 R. I. Cukier

Ovarian cancer remains one of the most lethal gynecological malignancies, largely due to late diagnosis and extensive heterogeneity across subtypes. Current diagnostic methods are limited in their ability to reveal underlying genomic…

Image and Video Processing · Electrical Eng. & Systems 2025-11-06 Gabriela Fernandes

Autoencoders and generative models produce some of the most spectacular deep learning results to date. However, understanding and controlling the latent space of these models presents a considerable challenge. Drawing inspiration from…

Computer Vision and Pattern Recognition · Computer Science 2020-06-16 Chi-Hieu Pham , Saïd Ladjal , Alasdair Newson

Gastrointestinal (GI) imaging via Wireless Capsule Endoscopy (WCE) generates a large number of images requiring manual screening. Deep learning-based Clinical Decision Support (CDS) systems can assist screening, yet their performance relies…

Computer Vision and Pattern Recognition · Computer Science 2026-02-13 Dimitrios E. Diamantis , Dimitris K. Iakovidis
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