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The interactions between diffusing molecules and membrane-bound receptors drive numerous cellular processes. In this work, we develop a spatial model of molecular interactions with membrane receptors by homogenizing the cell membrane and…

Quantitative Methods · Quantitative Biology 2025-01-24 Anil Cengiz , Sean D Lawley

Equilibrium Constant Differential Equations (ECDE) are derived for several nanoconfined elemental bimolecular reactions in the frameworks of statistical mechanics and the ideal gas model. The ECDEs complement the well-known…

Chemical Physics · Physics 2020-07-15 Leonid Rubinovich , Micha Polak

The Chemical Master Equation (CME) is well known to provide the highest resolution models of a biochemical reaction network. Unfortunately, even simulating the CME can be a challenging task. For this reason more simple approximations to the…

Optimization and Control · Mathematics 2015-10-21 Aivar Sootla , James Anderson

Machine learning has recently emerged as a powerful tool for generating new molecular and material structures. The success of state-of-the-art models stems from their ability to incorporate physical symmetries, such as translation,…

Machine Learning · Computer Science 2024-05-16 Bingqing Cheng

In this paper, we address the modeling issues of cell movement and division with a special focus on the phenomenon of volume exclusion in a lattice-based, exact stochastic simulation framework. We propose a new exact method, called Reduced…

Populations and Evolution · Quantitative Biology 2022-08-10 Peter Boldog

Biological cells can exchange messages through soluble molecules or membrane-bound receptors. In particular in the latter case, the interaction is usually located in specific regions of the interacting cells and may depend on or induce…

Quantitative Methods · Quantitative Biology 2023-12-12 Thorsten Prüstel , Martin Meier-Schellersheim

Multiple time scales problems are investigated by combining geometrical and analytical approaches. More precisely, for fast-slow reaction-diffusion systems, we first prove the existence of slow manifolds for the abstract problem under the…

Analysis of PDEs · Mathematics 2025-01-29 Laurent Desvillettes , Christian Kuehn , Jan-Eric Sulzbach , Bao Quoc Tang , Bao-Ngoc Tran

Particle-based stochastic reaction-diffusion (PBSRD) models are a popular approach for capturing stochasticity in reaction and transport processes across biological systems. In some contexts, the overdamped approximation inherent in such…

Biological Physics · Physics 2025-06-17 Samuel A. Isaacson , Qianhan Liu , Konstantinos Spiliopoulos , Chen Yao

Well-mixed chemical reaction networks (CRNs) contain many distinct chemical species with copy numbers that fluctuate in correlated ways. While those correlations are typically monitored via Monte Carlo sampling of stochastic trajectories,…

Statistical Mechanics · Physics 2026-01-14 John P. Zima , Schuyler B. Nicholson , Todd R. Gingrich

A spatio-temporal evolution of chemicals appearing in a reversible enzyme reaction and modelled by a four component reaction-diffusion system with the reaction terms obtained by the law of mass action is considered. The large time behaviour…

Analysis of PDEs · Mathematics 2016-10-25 Jan Elias

A gradient discretisation method (GDM), Gradient schemes, Convergence analysis, Existence of weak solutions, Anisotropic reaction diffusion models, Dirichlet and Neumann boundary conditions, Non conforming finite element methods, Finite…

Numerical Analysis · Mathematics 2020-09-02 Yahya Alnashri , Hasan Alzubaidi

The paper treats a reaction-diffusion equation with hysteretic nonlinearity on a one-dimensional lattice. It arises as a result of the spatial discretization of the corresponding continuous model with so-called nontransverse initial data…

Analysis of PDEs · Mathematics 2016-01-22 Pavel Gurevich , Sergey Tikhomirov

Experimental studies of protein-pattern formation have stimulated new interest in the dynamics of reaction-diffusion systems. However, a comprehensive theoretical understanding of the dynamics of such highly nonlinear, spatially extended…

Pattern Formation and Solitons · Physics 2020-11-24 Fridtjof Brauns , Jacob Halatek , Erwin Frey

In this paper, we first present a multiple-relaxation-time lattice Boltzmann (MRT-LB) model for one-dimensional diffusion equation where the D1Q3 (three discrete velocities in one-dimensional space) lattice structure is considered. Then…

Numerical Analysis · Mathematics 2021-08-04 Yuxin Lin , Ning Hong , Baochang Shi , Zhenhua Chai

We develop a Split Reactive Brownian Dynamics (SRBD) algorithm for particle simulations of reaction-diffusion systems based on the Doi or volume reactivity model, in which pairs of particles react with a specified Poisson rate if they are…

Statistical Mechanics · Physics 2018-09-05 Aleksandar Donev , Chiao-Yu Yang , Changho Kim

A new upscaling procedure that provides 1D representations of 2D mixing-limited reactive transport systems is developed and applied. A key complication with upscaled models in this setting is that the procedure must differentiate between…

Fluid Dynamics · Physics 2022-10-05 Ricardo H. Deucher , Louis J. Durlofsky

This paper considers quadratic and super-quadratic reaction-diffusion systems for reversible chemistry, for which all species satisfy uniform-in-time $L^1$ a-priori estimates, for instance, as a consequence of suitable mass conservation…

Analysis of PDEs · Mathematics 2015-11-26 Klemens Fellner , Evangelos Latos , Takashi Suzuki

In this work, we first develop a general mesoscopic multiple-relaxation-time lattice Boltzmann (MRT-LB) model for the two-dimensional diffusion equation with the constant diffusion coefficient and source term, where the D2Q5 (five discrete…

Numerical Analysis · Mathematics 2023-08-11 Ying Chen , Zhenhua Chai , Baochang Shi

We show that, for any spatially discretized system of reaction-diffusion, the approximate solution given by the explicit Euler time-discretization scheme converges to the exact time-continuous solution, provided that diffusion coefficient…

Optimization and Control · Mathematics 2019-12-12 Adrien Le Coënt , Laurent Fribourg

A novel extension of a rapid compression machine (RCM), namely a Rapid Compression Expansion Machine (RCEM), is described and its use for studying chemical kinetics is demonstrated. Like conventional RCMs, the RCEM quickly compresses a…

Chemical Physics · Physics 2016-06-21 Marc Werler , Robert Schiessl , Ulrich Maas